Purpose – Online retailing has attracted a lot of attention in recent years due to its great potential and significant implications for buyers sellers. This study adopts the stimulus-organism-response (S-O-R) framework illustrate how store layout design atmosphere influence consumers' shopping intention on website. Design/methodology/approach The sample this comprised 626 respondents from internet users. A structural equation model was employed identify interrelationships design, atmosphere,...

The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However, its potential lymphomagenesis remains unclear. In this study, we identified an immunosuppressive state patients with diffuse large B cell lymphoma (DLBCL), which was characterized by markedly elevated interleukin (IL)-18 levels tissues and positive correlation programmed death ligand 1 (PD-L1) expression. Furthermore, activation DLBCL lines upregulated PD-L1 reduced the proportion of cytotoxic T cells....

Leptochloa chinensis (L.) Nees, a noxious weed species commonly found in rice fields, has become significant challenge Jiangsu Province, China, as it developed resistance to multiple herbicides due extensive and continuous herbicide use recent years. Therefore, this study was conducted elucidate sensitivity differences the mechanisms underlying of L. Nees populations used across different regions China. A whole-plant bioassay assess 46 collected from various areas within several frequently...

Multidrug resistance (MDR) remains the major cause of disease relapse and poor prognosis in adults with acute myeloid leukemia (AML). Emerging evidence shows that drug not only exists against conventional chemotherapeutic drugs, but also limits efficacy new biological agents. Therefore, it is important to elucidate mechanisms through which AML patients develop resistance. MicroRNAs have been shown play an role regulating chemotherapy AML. A detailed understanding microRNA are clinically...

BackgroundHand, foot, and mouth disease (HFMD) is a contagious viral illness that commonly affects infants children. This infection an emerging infectious in Rizhao recent years. The present study examined the short-term effects of meteorological factors on adolescent HFMD Rizhao.DesignA generalized additive Poisson model was applied to estimate occurrence 2010–2012. Subgroup analyses were also conducted examine potential effect modifiers association terms age, sex, occupation.ResultsA...

Pentatricopeptide repeat (PPR) proteins comprise a large family of sequence-specific RNA binding in land plants. Because its size and frequent embryo lethality the mutants, molecular functions physiological roles many PPR are unknown. Through characterization an empty pericarp9 (emp9) mutant maize (Zea mays), we defined EMP9 mitochondrial editing, respiratory complex formation seed development. Mu insertions different regions Emp9 facilitated dissection domain EMP9. genetic functional...

Summary Splicing of plant organellar group II introns is under accurate nuclear control that employs many nucleus‐encoded protein cofactors from various families. For mitochondrial introns, only a few splicing factors have been characterized because disruption their functions often causes embryo lethality. Here, we report the function Empty Pericarp8 ( Emp8 ) in three mitochondria, complex I biogenesis, and seed development maize . encodes P subfamily pentatricopeptide repeat localizes...

Introduction Nonalcoholic steatohepatitis (NASH), also known as metabolic steatohepatitis, is a clinical syndrome with pathological changes like alcoholic hepatitis but without history of excessive alcohol consumption. NASH closely related to disorders such obesity, insulin resistance, type 2 diabetes mellitus, and hyperlipidemia. Its main characteristics are hepatocyte steatosis injury inflammation. In severe cases, it can develop into liver cirrhosis. At present, there no special treatment...

This study estimated the effects of ambient temperature and relative humidity on hospital admissions for ischemic stroke during 1990-2009 in Jinan, China.To account possible delayed harvesting effect, we examined impact meteorological factors up to 30 days before each admission using a distributed lag non-linear model; controlled season, long-term trend, day week public holidays analysis. Stratified analyses were also done summer winter.A total 1,908 observed between 1990 2009. We found...

In Brief We conducted a cross-sectional study on prevalence of human immunodeficiency virus (HIV) and syphilis among female sex workers (FSWs) recruited from different types venues in 6 cities China. Among 5322 FSWs (1379 were high-tier venues, 2482 middle-tier 1461 low-tier respectively), overall HIV was 0.54% (95% confidence interval [CI], 0.37%– 0.76%). By typology where solicited clients, the 1.37% CI, 0.89%–2.11%) 0.28% 0.14%– 0.58%) 0.07% 0.01%–0.41%) venues. The final logistic...

Summary RNA editing plays an important role in organellar gene expression plants, and pentatricopeptide repeat ( PPR ) proteins are involved this function. Because of its large family size, many not known for their function roles plant growth development. Through genetic molecular analyses the empty pericarp18 emp18 mutant maize Zea mays ), we cloned Emp18 gene, revealed function, defined mitochondrial complex assembly seed encodes a mitochondrial‐localized DYW ‐ protein. Null mutation...

Group II introns are ribozymes that can excise themselves from precursor-RNA transcripts, but plant organellar group have structural deviations inhibit ribozyme activity. Therefore, splicing of these requires the assistance nuclear- and/or organellar-encoded factors; however, how factors function remains unclear. In this study, we report functions and interactions two factors, PPR-SMR1 Zm-mCSF1, in intron maize mitochondria. is a SMR domain-containing pentatricopeptide repeat (PPR) protein...

This research focuses on investigating whether organisational identification mediates the effects of job security in‐role behaviour and extra‐role how these mediation mechanisms differ according to gender. Through analysing 212 supervisor‐subordinate dyads from a Chinese air transportation group, indicated that partially mediated effect fully behaviour. A multi‐group analysis also showed there were significant differences between male female employees in relationships. In addition, moderated...

Pentatricopeptide repeat (PPR) proteins are helical RNA-binding that function in RNA processing by conferring sequence-specific activity. Owing to the lethality of PPR mutants, functions many remain obscure. In this study, we report PPR20 intron splicing mitochondria and its role maize seed development. is a P-type protein targeted mitochondria. The ppr20 mutants display slow embryo endosperm Null mutation severely reduces cis-splicing mitochondrial nad2 3, resulting reduction assembly...

The current tumor node metastasis ( TNM ) staging system is inadequate for identifying high‐risk gastric cancer GC patients. Using a systematic and comprehensive‐biomarker discovery validation approach, we attempted to build micro RNA (miRNA)‐recurrence classifier MRC improve the prognostic prediction of . We identified 312 differentially expressed mi s in 446 tissues compared 45 normal controls by analyzing high‐throughput data from Cancer Genome Atlas TCGA ). Cox regression model,...

Recommender systems have long struggled with challenges such as cold start and data sparsity, which can lead to poor recommendation performance. While previous approaches attempted address these issues by incorporating side information, they often introduce noise, lack flexibility for expansion, suffer from inconsistent quality—factors that hinder accurate user preference inference reduce With the vast knowledge bases advanced reasoning capabilities of large language models (LLMs), are...

The rapid plasma reagin (RPR) test, a traditional method for diagnosing syphilis and evaluating treatment efficacy, relies on subjective interpretation requires high technical proficiency. This study aimed to develop validate user-friendly RPR-artificial intelligence (AI) interpretative tool. A dataset comprising 600 images of photographed RPR cards from 276 negative 223 positive samples was used model development. reference result based consistent interpretations by at least two out three...

In Brief Background: There have been limited data on molecular epidemiology of syphilis in China. This study aimed to analyze strain type distribution Treponema pallidum causing early across geographic areas China using an enhanced method. Methods: Genital samples were collected from patients East, South, and North Positive DNA T. was analyzed by arp, tpr, tp0548 genes. Results: Sufficient for full typing existed 197 324 samples, 27 types identified. A range 3 20 repeats (except 4, 11, 19...

This study assessed the epidemiology of sexually transmitted infections (STIs), HIV, and associated risk factors among female sex workers (FSWs) in Guangxi autonomous region, China. A cross-sectional 488 FSWs was conducted using a structured questionnaire to collect sociodemographic behavioral information. Biological specimens from subjects were sampled detect various STIs HIV infection. Among FSWs, prevalence rates syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, genital herpes,...

In plants, splicing of organellar group II introns involves numerous nucleus-encoded trans-factors. But, how these trans-factors function and interact is not well understood. Here we report the a pentatricopeptide repeat (PPR) protein PPR14 its physical relationship with other factors in mitochondria. Null mutations severely arrest embryo endosperm development, causing an empty pericarp phenotype. required for NADH dehydrogenase 2 (nad2) intron 3 nad7 1 The absence nad2 transcripts leads to...