A5057481978- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Bioinformatics and Genomic Networks
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- MicroRNA in disease regulation
- Gene expression and cancer classification
- Graph Theory and Algorithms
- RNA modifications and cancer
- Data Management and Algorithms
- Cancer-related molecular mechanisms research
- Advanced Graph Neural Networks
- Biomedical Text Mining and Ontologies
- Genomics and Phylogenetic Studies
- Complex Network Analysis Techniques
- Computational Drug Discovery Methods
- Celiac Disease Research and Management
- RNA and protein synthesis mechanisms
- Semantic Web and Ontologies
- Algorithms and Data Compression
- Microbial Metabolic Engineering and Bioproduction
- Machine Learning in Bioinformatics
- Data Mining Algorithms and Applications
- Anomaly Detection Techniques and Applications
- Gene Regulatory Network Analysis
University of Catania
2016-2025
Università Cattolica del Sacro Cuore
2023-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Catania
2005-2023
St. Antonius Ziekenhuis
2022
Marche Polytechnic University
2017
Institute of Genetics and Biophysics
2015
Parthenope University of Naples
2015
European Organization for Nuclear Research
2011-2014
Max Planck Institute for Molecular Biomedicine
2012-2014
Courant Institute of Mathematical Sciences
2007-2012
The relationship between the risk of celiac disease and both age at which gluten is introduced to a child's diet early dietary pattern unclear.We randomly assigned 832 newborns who had first-degree relative with introduction 6 months (group A) or 12 B). HLA genotype was determined 15 age, serologic screening for evaluated 15, 24, 36 5, 8, 10 years. Patients positive findings underwent intestinal biopsies. primary outcome prevalence autoimmunity overt among children 5 years age.Of 707...
To explore the performance of neutrophil-to-lymphocyte ratio (NLR), an index systemic inflammation that predicts prognosis several diseases, in a cohort elderly adults with community-acquired pneumonia (CAP).Prospective clinical study from January 2014 to July 2016.Unit Internal Medicine, University Catania, Italy.Elderly admitted for CAP (N = 195).Clinical diagnosis was defined as presence new infiltrate on plain chest radiography or computed tomography associated one more suggestive...
Graphs can represent biological networks at the molecular, protein, or species level. An important query is to find all matches of a pattern graph target graph. Accomplishing this inherently difficult (NP-complete) and efficiency heuristic algorithms for problem may depend upon input graphs. The common aim existing eliminate unsuccessful mappings as early inexpensively possible.We propose new subgraph isomorphism algorithm which applies search strategy significantly reduce space without...
Triple negative breast cancer (TNBC) is a heterogeneous disease at the molecular, pathologic and clinical levels. To stratify TNBCs, we determined microRNA (miRNA) expression profiles, as well profiles of cancer-focused mRNA panel, in tumor, adjacent non-tumor (normal) lymph node metastatic lesion (mets) tissues, from 173 women with TNBCs; linked specific miRNA signatures to patient survival used miRNA/mRNA anti-correlations identify clinically genetically different TNBC subclasses. We also...
Abstract Motivation: The identification of drug–target interaction (DTI) represents a costly and time-consuming step in drug discovery design. Computational methods capable predicting reliable DTI play an important role the field. Recently, recommendation relying on network-based inference (NBI) have been proposed. However, such approaches implement naive topology-based do not take into account features within domain. Results: In this article, we present new NBI method, called domain...
MicroRNAs are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular messenger RNAs. They frequently dysregulated cancer and have shown great potential as tissue-based markers for classification prognostication. microRNAs also present extracellular human body fluids such serum, plasma, saliva, urine. Most circulating plasma serum cofractionate Argonaute2 (Ago2) protein. However, been found membrane-bound...
When it becomes completely possible for one to computationally forecast the impacts of harmful substances on humans, would be easier attempt addressing shortcomings existing safety testing chemicals. In this paper, we relay outcomes a community-facing DREAM contest prognosticate nature environment-based compounds, considering their likelihood have disadvantageous health-related effects human populace. Our research quantified cytotoxicity levels in 156 compounds across 884 lymphoblastic lines...
miRò is a web-based knowledge base that provides users with miRNA–phenotype associations in humans. It integrates data from various online sources, such as databases of miRNAs, ontologies, diseases and targets, into unified database equipped an intuitive flexible query interface mining facilities. The main goal the establishment which allows non-trivial analysis through sophisticated techniques introduction new layer between genes phenotypes inferred based on miRNAs annotations. Furthermore,...
Abstract Glycogen synthase kinase-3 β (GSK-3 ) has emerged as a critical factor in several pathways involved hippocampal neuronal maintenance and function. In Huntington’s disease (HD), there are early deficits both patients transgenic mouse models, which prompted us to investigate whether disease-specific changes GSK-3 expression may underlie these abnormalities. Thirty-three postmortem samples from HD (neuropathological grades 2–4) age- sex-matched normal control cases were analyzed using...
miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance ncRNAs as non-invasive biomarkers. An increasing amount experimental evidence shows are frequently dysregulated diseases. Further, have been discovered different forms, such exosomes, which circulate human body fluids. Thus, 2017 an effort to update and collect accumulating information on spread across scientific publications...
Abstract Summary: NetMatch is a Cytoscape plugin which allows searching biological networks for subcomponents matching given query. Queries may be approximate in the sense that certain parts of subgraph-query left unspecified. To make query creation process easy, drawing tool provided. bioinformatics software platform visualization and analysis networks. Availability: The full package, tutorial associated examples are available at following web sites:...
Network querying is a growing domain with vast applications ranging from screening compounds against database of known molecules to matching sub-networks across species. Graph indexing powerful method for searching large graphs. Most graph methods date tackle the exact (isomorphism) problem, limiting their applicability specific instances in which such matches exist. Here we provide novel cope more general, inexact problem. Our method, SIGMA, builds on approximating variant set-cover problem...
Advanced research requires intensive interaction among a multitude of actors, often possessing different expertise and usually working at distance from each other. The field collaborative aims to establish suitable models technologies properly support these interactions. In this article, we first present the reasons for an interest Bioinformatics in context by also suggesting some domains that could benefit research. We then review principles most relevant applications social networking,...
Over the past few years, experimental evidence has highlighted role of microRNAs to human diseases. miRNAs are critical for regulation cellular processes, and, therefore, their aberration can be among triggering causes pathological phenomena. They just one member large class non coding RNAs which include transcribed ultra-conserved regions (T-UCRs), small nucleolar (snoRNAs), PIWI-interacting (piRNAs), intergenic non-coding (lincRNAs) heterogeneous group long (lncRNAs). Their associations...
Posttranscriptional cross talk and communication between genes mediated by microRNA response element (MREs) yield large regulatory competing endogenous RNA (ceRNA) networks. Their inference may improve the understanding of pathologies shed new light on biological mechanisms. A variety RNA: messenger RNA, transcribed pseudogenes, noncoding circular proteins related to RNA-induced silencing complex interacting with transfer ribosomal have been experimentally proved be ceRNAs. We retrace ceRNA...