A5058995618- Lipid metabolism and biosynthesis
- Research in Cotton Cultivation
- Sunflower and Safflower Cultivation
- COVID-19 Clinical Research Studies
- Fatty Acid Research and Health
- Long-Term Effects of COVID-19
- Insect and Pesticide Research
- Per- and polyfluoroalkyl substances research
- Pesticide Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Air Quality and Health Impacts
- Animal Nutrition and Physiology
- Liver physiology and pathology
- Toxic Organic Pollutants Impact
- SARS-CoV-2 and COVID-19 Research
- Vitamin D Research Studies
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Botanical Studies and Applications
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Climate Change and Health Impacts
Huazhong University of Science and Technology
2014-2025
State Grid Corporation of China (China)
2024
University of Massachusetts Amherst
2016-2021
Tongji Hospital
2014-2021
Amherst College
2019
Tianjin University of Technology
2018
Beijing Anzhen Hospital
2013-2016
Capital Medical University
2016
Abstract Background Coronavirus disease 2019 (COVID-19) is a newly emerging infectious and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed clarify correlation systemic inflammation with severity outcomes in patients. Methods In this retrospective study, baseline characteristics, laboratory findings, treatments were compared among 317 laboratory-confirmed patients moderate,...
Follow-up study of coronavirus disease 2019 (COVID-19) survivors has rarely been reported. We aimed to investigate longitudinal changes in the characteristics COVID-19 after discharge.A total 594 discharged from Tongji Hospital Wuhan February 10 April 30, 2020 were included and followed up until May 17, 2021. Laboratory radiological findings, pulmonary function tests, electrocardiogram, symptoms signs analyzed.257 (51.2%) patients had at least one symptom 3 months post-discharge, which...
Cholangiocarcinoma (CCA) is a highly malignant bile duct cancer that tends to invade and metastasize early. The epithelial–mesenchymal transition (EMT) has been implicated in cell invasion metastasis, as well evasion of host immunity. In this study, we investigated the interaction between atypical protein kinase C‐iota (aPKC‐ι) Snail regulation EMT its relationship CCA immunosuppression. Our results demonstrated aPKC‐ι, Snail, infiltrated immunosuppressive cells were significantly...
Significance Obesity is associated with enhanced colonic inflammation, which a major risk factor for colorectal cancer. To date, the mechanisms by obesity increases inflammation are not well-understood, and there few effective strategies controlling obesity-induced diseases. Here, using LC-MS/MS–based metabolomics, we report that soluble epoxide hydrolase (sEH) could be novel therapeutic target inflammation. This lead to rapid human translation, as pharmacological inhibitors of sEH being...
Camelina sativa is an emerging dedicated oilseed crop designed for biofuel and biodiesel applications as well a source edible general-purpose oils. Such valuable subjected to plant breeding programs suggested large-scale production of better seed oil quality. To accomplish this objective further enhance its content, understanding lipid metabolism at the molecular level in critical. Here, we applied tissue transcriptomics composition analysis identify profile genes gene networks associated...
Imidacloprid, a neonicotinoid insecticide, was previously reported to enhance adipogenesis and resulted in insulin resistance cell culture models. It also promote high fat diet-induced obesity male C57BL/6J mice. Thus, the goal of present study determine effects imidacloprid dietary interaction on development adiposity female Mice were fed with low (4% w/w) or (20% diet containing (0.06, 0.6, 6 mg/kg bw/day) for 12 weeks. (0.6 significantly enhanced weight gain adiposity. Treatment increased...
Abstract Background Coronavirus disease 2019 (COVID-19) has rapidly become a major international public health concern. This study was designed to evaluate the clinical characteristics and risk factors of COVID-19-associated liver injury. Methods A fraction 657 COVID-19 patients were retrospectively analyzed. Clinical laboratory data derived from electronic medical records compared between with or without Multivariate logistic regression method used analyze for Results Among patients, 303...
As the major component in cell wall of brown algae, alginates are degradable by alginate lyases via β-elimination. Alginate can be categorized into various polysaccharide lyase (PL) families, and PL7 family largest group divided six subfamilies. However, difference among different subfamilies is not fully understood. In this work, a marine lyase, VaAly2, from Vibrio alginolyticus ATCC 17749 belonging to PL7_5 subfamily was identified characterized. It displayed comparatively high alginolytic...
Background: Epidemiology studies have shown a consistently increased risk of acute myocardial infarction (AMI) correlated with particulate matter (PM) exposure. However, little is known about the association specific AMI subtypes. In this work, we investigated between short-term PM exposure and emergency department visits (EDVs) for AMI, ST-elevation (STEMI), non-ST-elevation (NSTEMI).Methods: We based case-crossover study on 2749 patients from Chaoyang District hospitalized in Anzhen...
Objective Enzymatic metabolism of polyunsaturated fatty acids leads to formation bioactive lipid metabolites (LMs). Previous studies have shown that obesity deregulation LMs in adipose tissues. However, most previous focused on a single or limited number LMs, and few systematical analyses been carried out. Methods A LC‐MS/MS‐based lipidomics approach was used, which can analyze >100 produced by cyclooxygenase, lipoxygenase, cytochrome P450 (CYP) enzymes, the profile high‐fat diet‐induced...
<italic>trans</italic>-Trismethoxy resveratrol reduced fat accumulation <italic>via</italic> the regulation of FAT-6 and FAT-7, stearoyl-CoA desaturases homologs, in <italic>Caenorhabditis elegans</italic>.
Histone deacetylases (HDACs) have been implicated in multiple malignant tumors, and HDAC inhibitors (HDACIs) exert anti-cancer effects. However, the expression of HDACs anti-tumor mechanism HDACIs cholangiocarcinoma (CCA) not yet elucidated. In this study, we found that 2, 3, 8 were up-regulated CCA tissues those patients with high HDAC2 and/or HDAC3 had a worse prognosis. cells, two HDACIs, trichostatin (TSA) vorinostat (SAHA), suppressed proliferation induced apoptosis G2/M cycle arrest....
Frying in vegetable oil is a popular cooking and food processing method worldwide; as result, the oils used for frying are widely consumed by general public it of practical importance to better understand their health impacts. To date, effects consumption on human inconclusive, making difficult establish dietary recommendations or guidelines. Here we show that administration oil, which was prepared under conditions good commercial practice, exaggerated dextran sodium sulfate (DSS)-induced...
Epithelial-to-mesenchymal transition (EMT) has an important role in invasion and metastasis of hepatocellular carcinoma (HCC). To explore the regulatory mechanism atypical protein kinase C ι (aPKCι) signaling pathways to HCC development, find agent for targeted therapy HCC, immortalized murine hepatocytes were employed establish EMT cell model MMH-RT cells. Our study showed that took place MMH-R cells under effect transforming growth factor-β1 (TGF-β1) overexpressing aPKCι. Furthermore, we...
Cholangiocarcinoma (CCA) invasion and metastasis are the primary causes of poor survival rates in patients. The epithelial-mesenchymal transition (EMT) is a crucial step cancer metastasis. However, it still unclear molecular mechanism. In this study, expression 14-3-3ζ atypical protein kinase C-ι (aPKC-ι) was further detected CCA tissues cell lines. Meanwhile, we established EMT model cells investigated aPKC-ι co-regulatory effect on vitro vivo. Further, identified downstream glycogen...
Per- and poly-fluoroalkyl substances, especially perfluorooctanesulfonic acid (PFOS), have been extensively used for over 50 years. A growing body of evidence has emerged demonstrating the potential adverse effects these including its effect on development non-alcoholic fatty liver disease, as one most prevalent chronic diseases. Nonetheless, there is no report perfluorobutanesulfonic (PFBS), major replacement PFOS, disease. Therefore, PFBS exposure fat accumulation in a human hepatoma cell...