A5090156189- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Bone and Joint Diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Hematological disorders and diagnostics
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- interferon and immune responses
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
First Affiliated Hospital of GuangXi Medical University
2024-2025
Guangxi Medical University
2024-2025
Shenzhen Institutes of Advanced Technology
2024-2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Fudan University
2025
Westlake University
2025
China-Japan Friendship Hospital
2023
Peking University
2023
Donafenib is an improved version of sorafenib in which deuterium substituted into the drug's chemical structure, enhancing its stability and antitumor activity. exhibits enhanced activity better tolerance than preclinical clinical studies. However, specific mechanism effect on hepatocellular carcinoma has not been reported. Iron deposition a cell death pattern caused by disturbances iron metabolism. Apoptosis form programmed death. They may interact with each other during This study mainly...
Abstract Inactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution smad4 loss to drug resistance PDAC is largely undetermined. In present study, we reported that SMAD4 endows cells ability through upregulating histone lysine demethylase, Lysine-Specific Demethylase 5B (KDM5B, also known as JARID1B or PLU1). Upregulated KDM5B was found PDAC, associated with poor...
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is deeply relevant to damage and dysfunction bone microvascular endothelial cells (BMECs). Recently, necroptosis, a newly programmed cell death with necrotic appearance, has garnered increasing attention. Luteolin, flavonoid compound derived from Rhizoma Drynariae, numerous pharmacological properties. However, effect Luteolin on BMECs in GIONFH through necroptosis pathway not been extensively investigated. Based network...
1-Bromoacetyl-3,3-dinitroazetidine (RRx-001) has potent antitumor effects, indicating its promising therapeutic potential against various cancers. This research investigates RRx-001 activity hepatocellular carcinoma (HCC) and elucidates underlying mechanisms.
Abstract Infection with the Hepatitis B virus (HBV) is a key risk factor for Hepatocellular carcinoma (HCC) development and progression. It widely recognized that immunopathological mechanisms are pivotal in developing HBV-related HCC. Nevertheless, specific by which HBV-induced modifications within tumor microenvironment (TME) contribute to HCC pathogenesis still not well understood. Here, we utilized single-cell RNA sequencing analyze compare immune landscapes between HBV-positive...