A5054071082- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Birth, Development, and Health
- Gout, Hyperuricemia, Uric Acid
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
Hebei Medical University
2016-2025
Hebei General Hospital
2016-2025
Yunnan Agricultural University
2025
Hospital of Hebei Province
2005-2024
Dalian Maternal and Child Health Hospital
2020-2024
North China University of Science and Technology
2022
Hebei North University
2022
Dalian Medical University
2019-2020
Hebei Yiling Hospital
2020
Weatherford College
2019
The past 30 years have witnessed significant increases in the prevalence of type 2 diabetes mellitus (T2DM) China. A 1980 epidemiological survey that included 000 people from 14 provinces and cities nationwide indicated was 0.67% 1. 1994–1995 210 19 found 2.5% among individuals who were 25–64 old (with a population standardized rate 2.2%) impaired glucose tolerance 3.2% 2.1%) 2. national nutrition conducted 2002, showed prevalences 4.5% 1.8% over 18 urban rural areas, respectively 3. In...
Cancer cells present sustained de novo fatty acid (FA) synthesis with increased production of saturated acids (SFAs) and monounsaturated (MUFAs). This change in FA metabolism is associated overexpression stearoyl-CoA desaturase 1 (SCD1), which catalyses the transformation SFAs into MUFAs (e.g., oleic acid). In this study, we provide new evidence that SCD1 inhibition leads to anti-proliferation effect breast cancer through induction apoptosis, cell cycle arrest migration prevention. However,...
Abstract Background Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence relationship between TyG and risk of diabetes remains limited. This study sought to explore association baseline with developing in Chinese adults. Methods retrospective cohort was conducted using data from health screening program China. A total 201,298 non-diabetic individuals were included. calculated Ln [fasting plasma...
High-fat diet (HFD)-feeding induces changes in the microbiome and increases intestinal permeability by impairing tight junction (TJ) protein function, which may explain insulin resistance (IR) associated pathologies. We aimed to determine effects of resveratrol (RES) on gut TJ proteins. Results showed that RES administration improved lipid profile, ameliorated endotoxemia, inflammation, barrier defect glucose intolerance HFD-fed mice. Furthermore, it modified microbial composition, reducing...
This study aimed to investigate how resveratrol (RSV) improves high-fat diet (HFD)-induced hepatic insulin resistance in mice via microRNA (miRNA) mmu-miR-363-3p vitro and vivo.C57BL/6J were fed a HFD for 8 weeks establish an model. The model treated or not with RSV 6 weeks. Differential miRNA expression mouse liver tissues was analyzed by high-throughput sequencing. Mouse HepG2 cells palmitic acid (PA) cell of resistance. transfected inhibitor mimic, the PI3K-Akt signaling pathway-related...
Purpose: The aim of the study was to examine effects resveratrol upon hepatic endoplasmic reticulum stress (ERS) and insulin sensitivity in vivo vitro. Material methods: C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks, resistance evaluated by intraperitoneal glucose tolerance test (IPGTT). Mice then treated with 12 weeks blood liver samples collected. Blood biochemical indicators determined kits, protein expression western blot, morphological changes observed histological staining....
Abstract Background Steamed wheat bread have previously been shown to induce comparatively high postprandial plasma glucose responses, on the contrary, buckwheat products induced lower glucose. The present study was assess effects of micronutrient enriched variety Jizi439 and in healthy diabetic subjects comparing with other varieties. Methods Two experiments were conducted levels randomly selected subjects. first experiment involved three types steamed equivalent 50 g available carbohydrate...
Abstract Insulin resistance (IR) is a common etiology of type 2 diabetes (T2D) defined by state decreased reactivity to insulin in multiple organs, such as the liver. This study aims investigate how microRNA‐122‐5p (miR‐122) regulates hepatic IR vitro. We first found that miR‐122 level was upregulated liver rats fed with high‐fat diet and injected streptozotocin (T2D rats), while expression insulin‐like growth factor 1 receptor (IGF‐1R), potential target miR‐122, downregulated diabetic In...
Resveratrol (RSV), a polyphenol, non‑flavonoid plant‑derived antitoxin, ameliorates hyperuricemia and kidney inflammation. The present study aimed to establish model of high‑fat diet (HFD)‑induced insulin resistance (IR) determine the specific mechanism RSV improve inflammation reduce uric acid (UA). C57BL/6J mice were fed HFD for 12 weeks their glucose tolerance was evaluated by intraperitoneal testing. then administered 6 weeks, blood samples collected. Serum UA concentrations determined...
The present study aimed to establish a model of palmitic acid (PA)‑induced insulin resistance (IR) in C2C12 cells and determine the mechanism underlying how resveratrol (RSV) improves IR. were divided into control (CON), PA, PA + RSV, RSV DNA damage‑inducible transcript 4 (DDIT4)‑small interfering (si)RNA MHY1485 (mTOR agonist) groups. Glucose contents culture medium triglyceride determined. Oil red O staining was performed observe pathological changes cells. Reverse...
The intestinal immune barrier is a developed and complex system, there fine synergy between it the induced response. Short-chain fatty acids (SCFAs) are main metabolites of microbial fermentation. In cecum pigs, SCFAs not only provide energy for host but also participate in regulating function system. purpose this study was to explore mechanism regulation gene expression porcine cecum. content mRNA levels genes were detected, Gene Ontology (GO) annotation, Kyoto Encyclopedia Genes Genomes...