A5011159150- Diabetes Management and Research
- Diabetes Management and Education
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Synthesis of β-Lactam Compounds
- CAR-T cell therapy research
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Family Support in Illness
- Phenothiazines and Benzothiazines Synthesis and Activities
- Total Knee Arthroplasty Outcomes
- Ubiquitin and proteasome pathways
- Child and Adolescent Psychosocial and Emotional Development
- Family and Patient Care in Intensive Care Units
- Tuberculosis Research and Epidemiology
- Chronic Disease Management Strategies
- Microbial Natural Products and Biosynthesis
- Diabetes and associated disorders
- Bacterial biofilms and quorum sensing
- Asymmetric Hydrogenation and Catalysis
- Cancer Immunotherapy and Biomarkers
- Synthesis and Catalytic Reactions
Oregon Health & Science University
2009-2025
La Trobe University
2019-2024
Peter MacCallum Cancer Centre
2024
The University of Melbourne
2024
Doernbecher Children's Hospital
2022
University of Memphis
2017-2022
Hartford Financial Services (United States)
2019-2021
Trinity Health
2020-2021
University of the West of England
2020
University of Akron
2019
Behavioral family systems therapy (BFST) for adolescents with diabetes has improved relationships and communication, but effects on adherence metabolic control were weak. We evaluated a revised intervention, BFST (BFST-D).One hundred four families randomized to standard care (SC) or 12 sessions of either an educational support group (ES) BFST-D over 6 months. Family relationships, adherence, glycosylated hemoglobin (HbA1c), health utilization measured at baseline after treatment.BFST-D...
OBJECTIVE—Studies showing that family communication and conflict resolution are critical to effective management of type 1 diabetes in adolescents have stimulated interest evaluating psychological treatments targeting these processes. Previous trials shown Behavioral Family Systems Therapy (BFST) improved parent-adolescent relationships but not treatment adherence or glycemic control. This study evaluates a revised intervention, BFST for Diabetes (BFST-D), modified achieve greater impact on...
Computer navigation has the potential to permit accurate placement of components. We first hypothesized acetabular inclination and anteversion using would be within 5° postoperative computed tomography scans, then secondly, computer precision better than that surgeons. In phase, we obtained CT scans in 30 hips ascertain values for cup. second 99 patients with 101 hips, determined surgeon's by comparing surgeons' blind estimates trial cup position values. The was 4.4° a bias 0.03° 4.1° 0.73°....
Background: Increasingly various technologies are being tested to deliver behavioral health care. Delivering services via videoconferencing shows promise. Given that the patient-provider relationship is a strong predictor of patient adherence medical regimens, addressing quality when not delivered face-to-face critical. To end, we compared therapeutic alliance care was youth with poorly controlled type 1 diabetes mellitus (T1DM) and their caregivers in-clinic same Internet-based (i.e.,...
Objective To examine "miscarried helping" as a maladaptive dyadic process in families of youth with chronic pain using the Actor–Partner Interdependence Model. Methods 210 adolescents (mean = 14.23 years; 73.9% female) and their parents participating multicenter study completed measures assessing characteristics, miscarried helping, family functioning, parental protectiveness, child depressive symptoms. Results Multilevel modeling revealed significant actor effects helping on functioning for...
The time-dependent effect of temperature and salt (NaCl) concentration on the corrosion behavior carbon steel in CO2-saturated environments were explored using various electrochemical techniques coupled with XRD, Raman spectroscopy SEM/FIB examinations. At constant level, rate increased stabilized when was below 60 °C. When higher than °C, firstly increased, reached an apex, then started decreasing continuously. magnitude decrease is inversely proportionally to concentration, which...
Associations among sibling relations and the psychosocial illness-specific adaptation of youths (N = 66) with insulin-dependent diabetes mellitus (IDDM) were examined. The findings suggest that relations, especially conflict, contribute an independent source variance above beyond contributed by demographic characteristics, constellation variables, important dimensions family in predicting youths' adaptation. High family-life stress high status/power unique internalizing behaviors, male...
SUMMARY: Staphylococci, micrococci and strains intermediate in guanine+cytosine (GC) content between these genera were all found to contain menaquinones. Two different types of menaquinone, described as 'normal' 'hydrogenated' revealed. Distinct stable menaquinone patterns, formed by the percentages individual isoprenologues, characterize certain previously proposed species, groups or subgroups within family. Studies on distribution menaquinones have also demonstrated heterogeneity...
OBJECTIVE—This article evaluates prediction of HbA1c during an 18-month randomized trial intensive therapy (IT) versus usual care (UC) for type 1 diabetes in 142 youth. RESEARCH DESIGN AND METHODS—Patients received a composite score self-management competence (SMC) that combined standardized scores on baseline measures knowledge, treatment adherence, and quality health interactions. They were categorized by tertiles split into low, moderate, high SMC levels. RESULTS—IT yielded very similar...
Abstract Background Current therapies fail to cure over a third of osteosarcoma patients and around three quarters those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are new class anti-cancer agents. Previous work revealed that cells from murine osteosarcomas were efficiently sensitized by physiologically achievable concentrations some Smac mimetics (including GDC-0152 LCL161) killing the inflammatory cytokine TNFα in vitro, but survived exposure sole Methods...
Abstract Objective Recruiting representative samples of youth for behavioral health interventions is challenging yet necessary to translate research into practice and eliminate disparities. Transition-aged with type 1 diabetes (T1D) represent a vulnerable population; not enough attention given their inclusion in interventions. Behavioral Family Systems Therapy Diabetes Transition (BFST-DT) an intervention aimed at improving transition readiness currently being pilot tested. The objectives...
Objective This article evaluated whether deviation from developmentally appropriate self-care autonomy moderated the effects of intensive therapy (IT) or usual care (UC) on glycosylated hemoglobin (HbA1C) in 142 youths with diabetes. Methods Youths received an autonomy/maturity ratio (AMR) score at baseline that was a standardized scores measures to psychological maturity and were categorized by tertile split into low, moderate, high AMR. Results Higher AMR associated higher HbA1C for IT UC....
AbstractThe assessment of youth executive functioning (EF) associated with diabetes management has been difficult to accomplish, yet is important optimizing adherence. To improve EF assessment, we developed the Diabetes Related Executive Functioning Scale (DREFS) and piloted its administration 50 type 1 their caregivers. Youth/caregiver dyads completed analogous versions DREFS, Behavioral Rating Inventory (BRIEF), Self-Administered Self-Management Profile (SA-DSMP). HbA1c assays were used as...
Phosphatidylcholine coatings have been shown to elute antibiotics for several days. A recently developed biofilm inhibitor, cis-2-decenoic acid (C2DA), has exhibit synergistic activity with common antibiotics. This study aims evaluate the effectiveness of C2DA and amikacin dual drug delivery from a phosphatidylcholine coating.(1) What are in vitro elution profiles phosphatidylcholine-coated coupons incubated phosphate-buffered saline? (2) Does presence eluate samples lower amount needed...
To evaluate the impact of pediatric sleep disturbances and night-time seizure monitoring children with rare epilepsy syndromes on quality mental health caregivers. A cross-sectional study was conducted using caregiver entered data from Rare Epilepsy Network Patient Reported Outcomes Measurement Information System measures for fatigue, disturbance, sleep-related impairment, depression, anxiety, companionship, cognition. Logistic regression used to examine associations between risk factors...
Abstract Osteosarcoma is the most common form of primary bone cancer, which primarily afflicts children and adolescents. Chemotherapy, consisting doxorubicin, cisplatin methotrexate (MAP) increased 5-year osteosarcoma survival rate from 20% to approximately 60% by 1980s. However, rates have remained stagnant for several decades. Patients whose disease fails respond MAP receive second-line treatments such as etoposide and, in more recent years, kinase inhibitor regorafenib. BCL-2 its close...
1-Amino-4-hydroxybutan-2-one (14) has been identified as one of the major products from hydrolysis clavulanic acid in acidic, alkaline, or neutral solution. In alkaline solution, amino ketone is converted into other products, including two pyrazines, 2,5-bis(2-hydroxyethyl)pyrazine and 3-ethyl-2,5-bis(2-hydroxyethyl)pyrazine. A rationale for formation these discussed.
Abstract. Introduction: Local antimicrobial delivery via calcium sulfate (CaSO4) beads is used as an adjunctive treatment for periprosthetic joint infection. There limited clinical information describing the performance of antimicrobial-loaded CaSO4 (ALCS) in large-scale applications. We developed a simulated large model to study properties eluting ALCS. Methods: The vitro testing platform was adapted standardized tribological prosthetic total hips and knees (ASTM F732). 70 mL fluid volume,...
Objective To examine 6-month follow-up data on the effectiveness of in-home Behavioral Family Systems Therapy (BFST) for adolescents with poorly controlled diabetes, using a pilot and feasibility study. Methods Eighteen diabetes received ten 90-min sessions BFST. Diabetes-related functioning, general family health status were assessed at baseline, immediately following treatment 6-months after treatment. Results Although initial posttreatment evaluation indicated decreases in conflict,...
OBJECTIVE Few validated measures exist to evaluate self-management of diabetes in families with limited English proficiency. The present study evaluated the psychometric properties and factorial equivalence a Spanish translation parent report version Diabetes Self-Management Profile (DSMP-Parent-Sp). RESEARCH DESIGN AND METHODS Hispanic youth (mean 13.7 years old) type 1 were recruited from three clinics South Florida represented wide range nationalities acculturation levels. A total 127...