A5051785622- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
- Anesthesia and Neurotoxicity Research
- Nonmelanoma Skin Cancer Studies
- Skin Protection and Aging
- Urological Disorders and Treatments
- Telomeres, Telomerase, and Senescence
- Cancer and Skin Lesions
- PARP inhibition in cancer therapy
- COVID-19 Clinical Research Studies
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Ferroptosis and cancer prognosis
Saarland University
2019-2022
Abstract Cellular senescence is an irreversible growth arrest that occurs as a result of damaging stimuli, including DNA damage and/or telomere shortening. Here, we investigate histone variant H2A.J new biomarker to detect senescent cells during human skin aging. Skin biopsies from healthy volunteers different ages (18–90 years) were analyzed for expression and other parameters involved in triggering maintaining cellular senescence. In the epidermis, proportions H2A.J-expressing...
Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify CYP19A1 gene encoding testosterone-to-estradiol metabolizing enzyme (also known aromatase) a host factor contributes to worsened in SARS-CoV-2-infected males. We analyzed exome sequencing data obtained from human cohort (n = 2,866) using machine-learning approach and CYP19A1-activity-increasing mutation...
Background: Despite technical advances in hippocampus-sparing radiotherapy, radiation-induced injury to neural stem cell compartments may affect neurocognitive functions. In pre-clinical mouse models with fractionated low-dose radiation (FLDR) and single-dose (SDR), the accurate response was analyzed different hippocampal subregions. Methods: Adult juvenile C57BL/6NCrl mice were exposed FLDR (20 × 0.1 Gy, daily exposure from Monday Friday for 4 weeks) or SDR (1 2 Gy). addition, 72 h after...
H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. showed cell-type specific expression with striking enrichment luminal epithelial cells multiple glands including those breast, prostate, pancreas, thyroid, stomach, salivary glands. was also highly expressed many carcinoma cell lines particular, derived from breast prostate cancer. thus appears be novel marker for cancers....
Precise molecular and cellular mechanisms of radiation-induced dermatitis are incompletely understood. Histone variant H2A.J is associated with senescence modulates senescence-associated secretory phenotype (SASP) after DNA-damaging insults, such as ionizing radiation (IR). Using ex vivo irradiated cultured foreskin, was analyzed a biomarker senescence, potentially initiating the inflammatory cascade skin injury. Human foreskin explants were collected from young donors, 10 Gy, in air-liquid...