A5050676289- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Proteoglycans and glycosaminoglycans research
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Barrier Structure and Function Studies
- Intensive Care Unit Cognitive Disorders
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Cancer-related cognitive impairment studies
- Advanced Glycation End Products research
- Dye analysis and toxicity
- Pharmacological Receptor Mechanisms and Effects
- Circular RNAs in diseases
University of Duisburg-Essen
2017-2025
University of Otago
2025
University of Tehran
2014-2024
Essen University Hospital
2018-2023
Shahid Sadoughi University of Medical Sciences and Health Services
2020
Background and Purpose— Small extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral ischemia in rodents reverse postischemic lymphopenia peripheral blood. Since blood cells, especially polymorphonuclear neutrophils (PMNs), contribute ischemic brain injury, we analyzed leukocyte responses sEVs investigated the role of PMNs sEV-induced neuroprotection. Methods— Male C57Bl6/j mice exposed transient...
The visualization of cerebral microvessels is essential for understanding brain remodeling after stroke. Injection dyes allows the evaluation perfused vessels, but has limitations related either to incomplete microvascular filling or leakage. In conventional histochemistry, analysis limited 2D structures, with apparent regarding interpretation vascular circuits. Herein, we developed a straight-forward technique visualize in whole ischemic mouse brain, combining injection fluorescent-labeled...
Background and Purpose- Poststroke, neuronal excitability is tonically reduced in peri-infarct tissue via inhibitory influences of extrasynaptic GABAA receptors. We hypothesized that α5 blockade by the competitive antagonist S44819 enhances postischemic neurological recovery, brain remodeling, neuroplasticity. Methods- In an explorative study followed a confirmation study, male C57Bl6/j mice were exposed to transient intraluminal middle cerebral artery occlusion. Starting 72 hours...
Stroke remains one of the leading causes long-term disability worldwide, and development effective restorative therapies is hindered by an incomplete understanding intrinsic brain recovery mechanisms. Growing evidence indicates that extracellular matrix (ECM) has major implications for neuroplasticity. Here we explored how perineuronal nets (PNNs), facet-like ECM layers surrounding fast-spiking interneurons, contribute to neurological after focal cerebral ischemia in mice with without...
<title>Abstract</title> Mutations in the tumor suppressor, <italic>TP53</italic>, are prevalent human cancers; yet their functional implications remain unclear. Through comprehensive pan-cancer database analysis, we identified H179 mutations <italic>TP53</italic> as significantly associated with poor disease-free survival across multiple cancer types. Functional studies lung, ovarian, and prostate cells overexpressing p53<sup>H179R/Y</sup> mutants revealed that these not only defective...
Glatiramer acetate (GA) is the first-line therapy for relapsing-remitting multiple sclerosis (MS) and increasingly demonstrating promising therapeutic benefits in a range of other conditions. Despite its extensive use, precise pharmacological mechanism GA remains unclear. In addition to T B cells, dendritic cells (DCs) monocytes play significant roles neuroinflammation associated with MS, positioning them as potential initial targets GA. Here, we investigated GA's influence on...
Sepsis predisposes for poor stroke outcome. This association suggests that sepsis disturbs post-ischemic tissue survival and brain remodeling. To elucidate this link, we herein exposed mice to 30 min intraluminal middle cerebral artery occlusion (MCAO) induced a sepsis-like state at 72 h post-ischemia by intraperitoneal delivery of Escherichia coli lipopolysaccharide (LPS; three doses 0.1 or 1 mg/kg, separated 6 h), major component the bacterium's outer membrane. Neurological recovery,...
The present study was designed to investigate the involvement of GABA-A receptors basolateral amygdala (BLA) in impairing effect acute stress on memory retrieval. BLAs adult male Wistar rats were bilaterally cannulated and retrieval measured a step-through type passive avoidance apparatus. Acute evoked by placing animals an elevated platform for 10, 20 30 min. results indicated that exposure min stress, but not 10 min, before testing (pre-test stress) decreased latency, indicating...
In contrast to lipopolysaccharide (LPS)-induced preconditioning, which has repeatedly been examined in the past, effects of post-ischemic LPS-induced sepsis, although clinically considerably more important, have not systemically studied. We exposed mice transient intraluminal middle cerebral artery occlusion (MCAO) and intraperitoneal LPS (0.1 or 1 mg/kg) was administered 24 h post-ischemia. Post-ischemic glial reactivity, neuronal survival neurological outcome were differently modulated by...
Abstract Calorie restriction confers post-ischemic neuroprotection, when administered in a defined time window before ischemic stroke. How hypocaloric diet influences stroke recovery initiated after has not been investigated. Male C57BL6/j mice were exposed to transient intraluminal middle cerebral artery occlusion. Immediately post-ischemia, randomized two groups receiving moderately (2286 kcal/kg food) or normocaloric (3518 kcal/kg) diets ad libitum. Animals sacrificed at 3 56 days...
Moderate dietary protein restriction confers neuroprotection when applied before ischemic stroke. How a moderately protein-reduced diet influences stroke recovery administered after stroke, is clinically relevant question. This question has not yet been investigated.Male C57BL6/J mice were exposed to transient intraluminal middle cerebral artery occlusion. Immediately the randomized two normocaloric diets: containing 8% (PRD) or normal 20% (ND). Post-stroke neurological deficits evaluated by...
Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action A receptor depends on amount intracellular chloride. Homeostasis chloride controlled by two co-transporters, NKCC1 and KCC2. Previous studies revealed that disturbed SCI. In this study, highly expressed epicenter lesioned at 3 hours after induction lesion reached peak around 6 Bumetanide (2 4 mg/day), as a specific inhibitor, was used post SCI for 28...
Malnutrition predisposes to poor stroke outcome. In animal models, undernutrition protected against ischemic injury in some, but not other studies. view of diverse models and food restriction paradigms, the consequences are poorly understood. Herein, we exposed mice energy-reduced protein-energy-reduced diets for 7–30 days subsequently induced intraluminal middle cerebral artery occlusion. Undernutrition phase dependently influenced injury. Short-lasting 7 protein-energy undernutrition,...