Air pollution epidemic The lockdown enforced in most cities China response to the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted virtual absence motor vehicle traffic and sharply reduced manufacturing activity for several weeks. Le et al. report some anticipated unanticipated effects that this had on air there, including unexpectedly high levels particulate matter abundances haze formation areas. This natural experiment will help assessment mitigation...

Abstract Human induced pluripotent stem cell (hiPSC)‐derived cardiac organoids (COs) have shown great potential in modelling human heart development and cardiovascular diseases, a leading cause of global death. However, several limitations such as low reproducibility, limited vascularization difficulty formation chamber were yet to be overcome. We established new method for robust generation COs, via combination methodologies hiPSC‐derived vascular spheres directly differentiated...

Significance We capitalize on large variations of urban air quality during the COVID-19 pandemic and real-time observations traffic, meteorology, pollution in Los Angeles to develop a machine-learning prediction model. Such model can adequately account for nonlinear relationships between emissions, atmospheric chemistry, meteorological factors. Moreover, this enables us identify key drivers air-quality assess effect future traffic-emission controls quality. unambiguously demonstrate that...

Air pollution poses a critical public health threat around many megacities but in an uneven manner. Conventional models are limited to depict the highly spatial- and time-varying patterns of ambient pollutant exposures at community scale for megacities. Here, we developed machine-learning approach that leverages dynamic traffic profiles continuously estimate community-level year-long air concentrations Los Angeles, U.S. We found introduction real-world data significantly improved spatial...

Chicoric acid (CA) has been reported to exhibit biological activities; it remains unclear, however, whether CA could regulate colitis via modulation of the gut microbiota and metabolites. This study aimed assess CA's impact on dextran sulfate sodium (DSS)-induced colitis, microbiota, Mice were induced with 2.5% DSS develop over a 7-day period. was administered intragastrically one week prior treatment continued for 14 days. The microbial composition in stool determined using 16S rRNA...

Autonomous learning is a topic of common concern in the education community. Various effective attempts and researches have been made around autonomous learning. However, carried out more context normal teaching, lacks exploration elementary student outside teaching scene. During COVID-19 epidemic, Second Elementary School Daxie, Ningbo City, Zhejiang Province adopted an online model to carry distance activities academic counseling, actively developed practices for students' independent at...

Cadmium could induce cell apoptosis, probably related to the dysfunction of mitochondrial respiratory chain. The human renal proximal tubule (HK-2) was used explore mechanism chain during apoptosis induced by cadmium chloride (CdCl2). Cell viability evaluated proliferation assay and different concentrations 60, 80 100 μM were selected evaluate toxicity CdCl2 respectively. Under treatment for 24 h, reactive oxygen species (ROS) HK-2 cells increased superoxide dismutase (SOD) activity...

Advanced oxidation techniques based on peroxysulfate activation have been paid much attention owing to their excellent performance in degrading stubborn pollutants water. In response the current situation that requires more raw materials and higher costs involves complicated processes for preparation of Fe/C catalysts activate persulfates, novel (Fe/C-700, Fe/C-800, Fe/C-900 Fe/C-1000) were prepared by a high-temperature carbonization method at different pyrolysis temperatures (700, 800, 900...

Thermocyclic protection performance of ultrahigh temperature ceramic coatings is crucial for the reusability carbon-based composites. In this work, slurry method combined with vapor phase siliconizing was used to prepare SiC–Si–Hf(Ta)B2 changing Hf/Ta proportion on surfaces graphite substrates. The prepared had a dense structure and were tightly bonded (HfTa)B2 solid solution SiC particles collectively embedded in consecutive Si. After 100 h oxidation at 1600 °C (5 × 20 cycles), mass coated...

Autonomous learning is a topic of common concern in the education community. Various effective attempts and researches have been made around autonomous learning. However, carried out more context normal teaching, lacks exploration elementary student outside teaching scene. During COVID-19 epidemic, Second Elementary School Daxie, Ningbo City, Zhejiang Province adopted an online model to carry distance activities academic counseling, actively developed practices for students' independent at...

To improve the utilization of okra seed, acidic and enzymatic hydrolyses producing protein hydrolysates were respectively optimized by orthogonal experiment response surface methodology using degree hydrolysis (DH) as evaluating index. Amino acid composition antioxidant capacity in vitro two kinds both analyzed. The was 58.53 ± 1.92% under following condition: hydrolyzing time 40 hr, temperature 95°C, ratio solution to seed meal (OSM) powder 5:1 (V:W/ml:g), hydrochloric concentration 18%...

Food contaminants, particularly insecticides, are important factors contributing to obesity and other adverse effects. As the most widely used diamide insecticide worldwide, chlorantraniliprole (CP) is ubiquitous in food environment. However, influence of CP on gut microbiota remains unknown. In this study, we administered CP/carboxymethyl cellulose sodium C57BL/6J mice with a high-fat diet (HFD) via gavage for 13 weeks. The exposure induced significant increases body weight gain, fat mass,...

Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease, entails chronic inflammation of the gastrointestinal tract. The pathogenesis IBD implicates genetic factors, gut microbiome alterations, immune dysregulation, contributing to its increasing global prevalence. sturgeon-derived peptide, which exhibits promising anti-inflammatory effects, provides potential therapeutic insights for managing symptoms. This study aims elucidate mechanisms novel peptide...

The mitoepigenetic modifications may be closely related to cellular fate. Both the replicative and hydrogen peroxide (H2O2)-induced premature senescence models were used detect mitochondrial biological characteristics epigenetic factors during of human embryonic lung fibroblasts. quantity was decreased in two stages, while DNA (mtDNA) copy number increased significantly methyltransferases activity likewise. And acute mtROS accumulation could launch senescence. Later, persistent owned higher...

Abstract Energy has been propelling the development of human civilization for millennia. Humanity presently stands at Type 0.7276 on Kardashev Scale, which was proposed to quantify relationship between energy consumption and civilizations. However, current predictions remain underdeveloped models are oversimplified. In order improve precision prediction, we use machine learning random forest autoregressive integrated moving average simulate predict a global scale position humanity Scale...

Abstract. This study describes a modeling framework, model evaluation, and source apportionment to understand the causes of Los Angeles (LA) air pollution. A few major updates are applied Community Multiscale Air Quality (CMAQ) with high spatial resolution (1 km × 1 km). The include dynamic traffic emissions based on real-time, on-road information recent emission factors secondary organic aerosol (SOA) schemes represent volatile chemical products (VCPs). Meteorology is well predicted...

Pluto, Titan, and Triton make up a unique class of solar system bodies, with icy surfaces chemically reducing atmospheres rich in organic photochemistry haze formation. Hazes play important roles these atmospheres, physical chemical processes highly dependent on particle sizes, but the size distribution is currently poorly understood. Here we report observational evidence that Pluto's particles are bimodally distributed, which successfully reproduces full phase scattering observations from...

Abstract Background This study was aimed to investigate the epidemiological characteristic of pulmonary tuberculosis (PTB) in Haidian District, Beijing from 2005 2018 and provide suggestions for controlling (TB) development. Methods Epidemiological data about TB were obtained by Infectious Disease Reporting System at different levels medical institutions District 2018. The methods combined with χ 2 test used analyze distribution population, time, region diagnosis. Results In total, 14,449...

Objective To survey the residents for their understanding of Coronavirus Disease 2019 (COVID-19)-related knowledge, attitude and practices (KAP) in two hard hit provinces China to facilitate governmental decisions on strategies against disease. Methods We invited participants from Hubei Henan Provinces an internetbased starting 12:00 February 21, 2020 23. The included general conditions, KAP COVID-19, psychological status living conditions residents. Results effective response rate...

Trichloroacetic acid (TCA) is a common non-volatile by-product of chlorination disinfection for drinking water. It necessary to know the epigenetic toxicity and mechanisms establishing safe exposure limit environmental TCA exposure. This study explored histone modification variations TCA-treated human hepatocytes L-02 at different time concentrations. (0.1 mM, 0.3 mM 0.9 mM) had an inhibitory effect on growth cells, with no significant changes in morphology. Treated 24 h 48 h, cells showed...

Abstract. This study describes a modeling framework, model evaluation, and source apportionment to understand the causes of Los Angeles (LA) air pollution. A few major updates are applied Community Multiscale Air Quality (CMAQ) Model with high spatial resolution (1 km × 1 km). The include dynamic traffic emissions based on real-time on-road information recent emission factors secondary organic aerosol (SOA) schemes represent volatile chemical products (VCP). Meteorology is well-predicted...