Lars Pilegaard Thomsen

ORCID: 0000-0003-0061-5833
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About
Contact & Profiles
Research Areas
  • Respiratory Support and Mechanisms
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Hemodynamic Monitoring and Therapy
  • Renal function and acid-base balance
  • Sepsis Diagnosis and Treatment
  • Cardiac Arrest and Resuscitation
  • Cardiovascular and exercise physiology
  • Analytical Chemistry and Sensors
  • Electrolyte and hormonal disorders
  • Heart Rate Variability and Autonomic Control
  • Lung Cancer Diagnosis and Treatment
  • Atomic and Subatomic Physics Research
  • Intensive Care Unit Cognitive Disorders
  • Non-Invasive Vital Sign Monitoring
  • Inhalation and Respiratory Drug Delivery
  • High Altitude and Hypoxia
  • Fuel Cells and Related Materials
  • Muscle activation and electromyography studies
  • Artificial Intelligence in Healthcare
  • Transportation Systems and Safety
  • Palliative Care and End-of-Life Issues
  • Clinical Reasoning and Diagnostic Skills
  • Radiomics and Machine Learning in Medical Imaging
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Bluetooth and Wireless Communication Technologies

Aalborg University
2015-2025

Background Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory associated with significant health decline and economic burdens. Pulmonary rehabilitation an effective intervention, but securing adherence to exercise difficult, particularly for frail disabled patients, challenged by leaving their home. Home-based emerging alternative persons COPD, long-term unclear. This study aims investigate the effects, experiences acceptability of home-based cycling patients COPD...

10.1136/bmjresp-2024-002573 article EN cc-by-nc-nd BMJ Open Respiratory Research 2025-01-01

Gas exchange impairment is primarily caused by ventilation-perfusion mismatch in chronic obstructive pulmonary disease (COPD), where diffusing capacity of the lungs for carbon monoxide (DLCO) remains clinical measure. This study investigates whether DLCO: (1) can predict respiratory COPD, that is, changes oxygen and dioxide (CO2); (2) associated with combined risk assessment score COPD (Global Initiative Chronic Obstructive Lung Disease (GOLD) score); (3) blood glucose body mass index (BMI)....

10.1177/1479972315601946 article EN Chronic Respiratory Disease 2015-08-31

Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from comorbidities. COPD severity may be evaluated by the Global initiative for Obstructive Lung Disease (GOLD) combined risk assessment score (GOLD score). Spirometry, body plethysmography, diffusing capacity of lung carbon monoxide (DLCO), and high-resolution computed tomography (HR-CT) measure function elucidate pathology. This study assesses associations between GOLD measurements in patients without (≤1) It...

10.2147/copd.s76124 article EN cc-by-nc International Journal of COPD 2015-02-01

International guidelines recommend that when changing FIO2 in patients with COPD receiving Long-Term Oxygen Therapy (LTOT), 30 minutes should be waited for steady state before measurement of arterial blood gasses. This study evaluates whether is really necessary, as a smaller duration might improve the logistics care, potentially reducing time spent by at out-patient clinic.12 severe to very according GOLD were included. Patients had median FEV1% 23% predicted value (range 15-64%), FEV1/FVC...

10.3109/15412555.2013.771161 article EN COPD Journal of Chronic Obstructive Pulmonary Disease 2013-03-28

Abstract Objectives Measurements of acid-base status are performed quickly after blood sampling avoiding errors. This necessitates rapid sample transport which can be problematic. study measures sampled in critically ill patients over 180 min and proposes a mathematical physio-chemical model to simulate changes. Methods Eleven samples were taken from 30 measured at baseline (2 samples) 36, 54, 72, 90, 108, 126, 144, 162, min. A was proposed including red cell metabolism, carbon dioxide...

10.1515/cclm-2024-1350 article EN Clinical Chemistry and Laboratory Medicine (CCLM) 2024-12-30

Accurate arterial blood gas (ABG) analysis is essential in the management of patients with hypercapnic respiratory failure, but repeated sampling requires technical expertise and painful. Missed common has a negative impact on patient care. A newer venous to conversion method (v-TAC, Roche) uses mathematical models acid-base chemistry, sample peripheral oxygen saturation calculate status. It potential replace routine ABG for selected cohorts. The aim this study was compare v-TAC ABG,...

10.1136/bmjresp-2022-001537 article EN cc-by-nc BMJ Open Respiratory Research 2023-06-01

Abstract Background Indirect calorimetry (IC) is considered the accurate way of measuring energy expenditure (EE). IC devices often apply Haldane transformation, introducing errors at inspiratory oxygen fraction (FiO 2 ) >60%. The aim was to assess measurement reliability and agreement between an unevaluated (device 2) (Beacon Caresystem, Mermaid Care A/S, Noerresundby, Denmark) not using transformation that does 1) (Ecovx, GE, Helsinki, Finland) varying FiO . Methods Twenty healthy male...

10.1002/ncp.10250 article EN Nutrition in Clinical Practice 2019-02-04

<b><i>Background:</i></b> Arterial blood gases are important when assessing acute or critically ill patients. Capillary and mathematical arterialization of venous have been proposed as alternative methods, eliminating pain complications arterial puncture. <b><i>Objectives:</i></b> This study compares the samples, arterialized capillary samples in ICU pulmonary ward <b><i>Method:</i></b> Ninety-one adult patients with...

10.1159/000512214 article EN Respiration 2021-01-01

Abstract Background ABGs are performed in acute conditions as the reference method for assessing acid-base status of blood. Hyperventilation and breath-holding common ventilatory changes that occur around time sampling, rapidly altering ‘true’ This is particularly relevant emergency medicine patients without permanent arterial catheters, where pain anxiety punctures can cause changes. study aimed to determine whether peripheral venous values could be a more reliable measure blood gases...

10.1186/s13049-021-00848-8 article EN cc-by Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2021-02-17

Early diagnosis of shock is a predetermining factor for good prognosis in intensive care. An elevated central venous to arterial PCO2 difference (∆PCO2) over 0.8 kPa (6 mm Hg) indicative low blood flow states. Disturbances around the time sampling could result inaccurate calculations ∆PCO2, thereby misrepresenting patient status. This study aimed determine influences acute changes ventilation on ∆PCO2 and understand its clinical implications.To investigate isolated effects eight pigs were...

10.1136/bmjresp-2021-000886 article EN cc-by-nc BMJ Open Respiratory Research 2021-03-01

The aim of the study was to investigate repetitive fractional exhaled nitric oxide (FeNO) measurements during high-dose radiation therapy (HDRT) and evaluate use FeNO predict symptomatic pneumonitis (RP) in patients being treated for non-small cell lung cancer (NSCLC).A total 50 with NSCLC referred HDRT were enrolled. measured at baseline, weekly HDRT, one month- every third month after a one-year follow-up period. mean FeNO(visit 0-6) calculated using arithmetic baseline HDRT. Patients...

10.1016/j.ctro.2019.09.004 article EN cc-by-nc-nd Clinical and Translational Radiation Oncology 2019-09-26

Hemoglobin Aalborg is a moderately unstable hemoglobin variant with no affiliation to serious hematological abnormality or major clinical symptoms under normal circumstances. Our index person was healthy woman of 58, not previously diagnosed hemoglobinopathy Aalborg, who developed acute respiratory failure after routine cholecystectomy. Initially she suspected idiopathic interstitial lung disease, yet series tests uncovered various abnormal physiological parameters and set the diagnosis...

10.1155/2014/701839 article EN cc-by Pulmonary Medicine 2014-01-01
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