A5101612113- Microbial Natural Products and Biosynthesis
- Dialysis and Renal Disease Management
- Carbohydrate Chemistry and Synthesis
- Plant-Microbe Interactions and Immunity
- Ideological and Political Education
- Chemical Synthesis and Analysis
- Genomics and Phylogenetic Studies
- Marine Sponges and Natural Products
- Cancer therapeutics and mechanisms
- Biofuel production and bioconversion
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Glycosylation and Glycoproteins Research
- Diabetes and associated disorders
- Bacterial Genetics and Biotechnology
- HIV/AIDS drug development and treatment
- Medical Research and Treatments
- Environmental Changes in China
- Proteoglycans and glycosaminoglycans research
- PARP inhibition in cancer therapy
- Electrolyte and hormonal disorders
- Alcoholism and Thiamine Deficiency
- Enhanced Recovery After Surgery
- Educational Reforms and Innovations
- Monoclonal and Polyclonal Antibodies Research
University of Chinese Academy of Sciences
2011-2025
Microbiology Institute of Shaanxi
2010-2025
Institute of Microbiology
2010-2025
Chinese Academy of Sciences
2010-2025
Nanchang University
2024
Second Affiliated Hospital of Nanchang University
2024
Central South University
2021-2022
Second Xiangya Hospital of Central South University
2021-2022
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Beijing Proteome Research Center
2021
ABSTRACT We previously demonstrated anaerobic conversion of the greenhouse gas methane into acetate using an engineered archaeon that produces methyl‐coenzyme M reductase (Mcr) from unculturable microorganisms a microbial mat in Black Sea to create first culturable prokaryote reverses methanogenesis and grows anaerobically on methane. In this work, we further same host with goal converting butanol. Instead, discovered process for secreted valuable product, L ‐lactate, sufficient optical...
Nikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces ansochromogenes. They competitive inhibitors chitin synthase and show potent fungicidal, insecticidal, acaricidal activities. Nikkomycin X Z the main components S. Generation high-producing strain is crucial to scale up nikkomycins production for further clinical trials.
Identifying hormone-like quorum sensing (QS) molecules in streptomycetes is challenging due to low production levels but essential for understanding secondary metabolite biosynthesis and morphological differentiation. This work reports the discovery of a novel γ-butenolide-type signaling molecule (SFB1) via overexpressing its biosynthetic gene (orf18) Streptomyces fradiae. SFB1 was found be tylosin through dissociating binding receptor TylP (a transcriptional repressor) target genes, thus...
Abstract Background Polyoxins are potent inhibitors of chitin synthetases in fungi and insects. The gene cluster responsible for biosynthesis polyoxins has been cloned sequenced from Streptomyces cacaoi tens polyoxin analogs have identified already. Results biosynthetic was heterologously expressed the sanN inactivated mutant ansochromogenes as a nikkomycin producer. Besides hybrid antibiotics (polynik A N) some known polyoxins, two novel were accumulated. One them is P that 5-aminohexuronic...
Streptothricins (STs) are used commercially to treat bacterial and fungal diseases in agriculture. Mining of the sequenced microbial genomes uncovered two cryptic ST clusters from Streptomyces sp. C TP-A0356. The cluster S. TP-A0356 was verified by successful heterologous expression coelicolor M145. Two new analogs were produced together with streptothricin F D host. further confirmed inactivation gene stnO, which proposed encoding an aminomutase supplying β-lysines for poly-β-Lys chain...
Serum albumin levels at a single time point have been shown to predict mortality in peritoneal dialysis (PD) patients. However, we believe that the dynamic change after PD may be more significant. In this study, investigated relationship between serum and clinical outcome of patients undergoing continuous ambulatory (CAPD). The participants study enrolled 586 who underwent CAPD center Second Xiangya Hospital China. We retrospectively reviewed medical records from January 1, 2010, December...
Postoperative gastrointestinal function recovery is critical for rapid rehabilitation of patients with tumors. Traditional Chinese medicine offers considerable advantages disease treatment. However, no study has reported the clinical efficacy intradermal needle therapy (INT) at Yuan-source, Luo-connecting, and He-sea points corresponding meridian in following surgery tumors.To investigate effect INT combined acupoints on patients' tumors.This randomized controlled trial was conducted Second...
Poly (ADP-ribose) polymerase (PARP) inhibitor olaparib selectively kills cancer cells with BRCA-deficiency and is approved for BRCA-mutated breast, ovarian pancreatic cancers by FDA. However, phase III study of failed to show a significant improvement in overall survival patients gastric (GC). To discover an effective biomarker GC patient-selection treatment, we analyzed proteomic profiling 12 cell lines. MTA2 was identified confer sensitivity aggravating olaparib-induced replication stress...
The number of elderly patients on peritoneal dialysis (PD) has rapidly increased in the past few decades. We sought to explore microbiology and outcomes peritonitis PD compared with younger patients. conducted a retrospective study analyze clinical characteristics, causative organism distribution, outcome all who developed between September 1, 2014 December 31, 2020, from Second Xiangya Hospital, Central South University, China. Patients experienced were separated into groups. was defined as...
As an important place to cultivate cultural confidence, colleges and universities should guide students consciousness firm confidence on the basis of foreign language culture acquisition. In course advanced English, concept “building morality cultivating human beings” is integrated into every teaching link by introducing Chinese organically in four aspects: vocabulary, background, text content theme. While English majors’ cross-cultural communication ability critical thinking ability, also...
Correct classification diagnosis of diabetes is critical for timely and appropriate treatment, which partially depends on the multiple islet autoantibodies measurement combined analysis. This study reports plasmon-enhanced fluorescence protein microchip method, a fast, high-throughput, high sensitive to measure circulating autoantibodies. method can achieve analysis within few hours by using microliters serum. Combined improved discriminatory ability, especially diagnostic sensitivity....
Background Many factors are associated with post-treatment relapse in CHB patients, and there no effective to predict relapse. In this study, we investigate the influence their predictive value HBeAg positive (eP-CHB). Methods The were analyzed firstly by a retrospective study eP-CHB. Variables included age, sex, regimen, baseline HBV DNA level, total course of treatment as well duration consolidation therapy after seroconversion. effects evaluated an eP-CHB prospective cohort. Results 89...
Abstract The microbiology and outcomes of peritoneal dialysis (PD) related peritonitis in elderly patients have not been thoroughly investigated. We aimed to investigate the microbiological distribution clinical outcome with PD-associated guide practice. conducted a prospective, one center cohort study Hunan province, China from September 1, 2014 December 31, 2020. Among incident (n =279), basic characteristics, pathogen prognosis PD (up 65 years, n = 64) were compared those aged under years...