A5062548852- Inflammatory Bowel Disease
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders
- Colorectal and Anal Carcinomas
- Hidradenitis Suppurativa and Treatments
- Inflammasome and immune disorders
- Colorectal Cancer Surgical Treatments
- Dermatological and COVID-19 studies
- Diagnosis and treatment of tuberculosis
- Pharmaceutical studies and practices
- Gastrointestinal Tumor Research and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Gastrointestinal disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pelvic floor disorders treatments
- Celiac Disease Research and Management
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Biosimilars and Bioanalytical Methods
- Bartonella species infections research
Ghent University Hospital
2020-2025
Ghent University
2021-2024
St Mark's Hospital
2020-2022
AZ Delta
2017
Background: Data on ustekinumab and vedolizumab in the elderly inflammatory bowel disease (IBD) population are limited. The aim of current study was to assess safety effectiveness both an real-life population. Methods: A multicentric retrospective performed IBD patients who started or between 2010 2020. Clinical endoscopic remission rates (serious) adverse events (AE) were assessed. Results: total 911 included, with 171 (19%) aged above 60 (111 VDZ, UST). Elderly treated had increased risk...
Abstract Background and Aims No consensus exists on optimal strategy to prevent postoperative recurrence [POR] after ileocaecal resection [ICR] for Crohn’s disease [CD]. We compared early medical prophylaxis versus expectant management with treatment driven by findings at elective endoscopy 6–12 months ICR. Methods A retrospective, multicentric, observational study was performed. CD patients undergoing first ICR were assigned Cohort 1 if a biologic or immunomodulator [re]started...
Extra-intestinal manifestations are frequently reported in inflammatory bowel diseases. However, data comparing the effect of vedolizumab and ustekinumab on articular extra-intestinal limited. The aim here was to evaluate differences new-onset evolution pre-existing joint during both treatments.An international multicentre retrospective study performed disease patients who started or between May 2010 December 2020. were assessed at baseline evaluated throughout 2-year follow-up. Arthropathy...
Background/Objectives: Gastrointestinal diseases are a major cause of morbidity in common variable immunodeficiency disorder (CVID), clinically often mimicking other conditions including celiac disease and inflammatory bowel (IBD). Hence, diagnosis CVID remains challenging. This study aims to raise awareness highlight histopathological clues for intestinal biopsies, emphasizing diagnostic pitfalls the pathologist/gastroenterologist. Methods: We reviewed 63 (18 duodenal, 23 ileal, 22 colonic)...
Abstract Background Isolated perianal fistulae (IPAF) without concurrent luminal disease is an uncommon presentation of Crohn’s (CD), posing unique diagnostic and management challenges. IPAF in CD often show complex features, such as secondary tracts abscesses, respond poorly to standard treatments for crypto-glandular fistulae1. Data on the natural history, progression disease, effective remain limited. This study examines contemporary evaluation, clinical course, outcomes patients with...
Currently the effect of IL-1 blockade on ulcerative colitis (UC) is still ambiguous. This case report describes a patient with UC who developed severe complications after an episode azathioprineinduced pancytopenia including cytomegalovirus pneumonitis, hemophagocytic lymphohistiocytosis, and probable pulmonary aspergillosis. Imaging hospitalization revealed disseminated chronic candidiasis persisting inflammation was seen. Genetic testing heterozygous variants in NOD2 NLRP12, cytokine...
The aim of this Delphi study was to reach consensus on a new clinical decision tool help identify or exclude Crohn's disease (CD) in patients with perianal fistula(s) (PAF). A panel international experts the field proctology/inflammatory bowel invited participate. In first round (electronic survey), participants were asked anonymously provide their opinion probing (1) relevance and use characteristics suggestive underlying CD, (2) fecal calprotectin (FCP) for screening (3) diagnostic work-up...
Background The risks and impact of COVID19 disease vaccination in patients with Immune Mediated Inflammatory Diseases (IMID) remain incompletely understood. IMID particularly receiving immunosuppressive treatment were excluded from the original, registrational phase-3 efficacy safety trials. Real-world observational data can help to fill this gap knowledge. BELCOMID study aims explore interaction between IMIDs, immune-modulating modalities SARS-CoV-2 infection a real-life patient cohort....
A 20-year-old man was presented with ulcerative gastritis and duodenitis complicated by pyloric stenosis. Helicobacter pylori infection excluded, the lesions did not respond to treatment proton pump inhibitors. No other parts of intestinal tract showed signs inflammation. Histopathological review chronic inflammation granuloma formation. tentative diagnosis isolated upper gastrointestinal (UGI) Crohn’s disease performed. However, additional work-up revealed significantly positive IgG4...
Introduction Colonoscopy prevents colorectal cancer via the detection and resection of premalignant polyps. This effect may be attenuated by variations in polypectomy, with multiple techniques available a wide range experience amongst endoscopists. We assessed current practice against best contemporary evidence. Methods An online survey was distributed to members gastroenterological surgical societies seven countries during July 2017. Images polyps were presented respondents requested...
Since publication of the top 10 research priorities in inflammatory bowel disease (IBD) based on James Lind Alliance Priority Setting Partnership, question remains whether this has influenced IBD-research landscape. This study aimed to create an overview current distribution interests trials UK.The ClinicalTrials.gov database and European Union Clinical Trials Register were screened for clinical set up from 9 August 2016 16 November 2019 UK involving adult patients with IBD.Of 20...
Abstract Background Inflammatory bowel diseases (IBD) are predominantly diagnosed during the second to third life decade. However, disease may manifest itself at any age and current understanding of differences in clinical presentation therapy use among groups is still limited. We aimed analyse age-related patterns biological surgical treatment patients with IBD. Methods This study utilized data from PANTHER cohort, a prospective Belgian inception cohort including 473 adult IBD 3 referral...
Abstract Background Fistula cancer is a rare and often devastating diagnosis in patients with perianal fistulising Crohn’s disease (CD). management complex process requiring multi-disciplinary effort. However, given the low incidence subsequent lack of data clinical trials field, there little to no guidance on screening fistula cancer. To inform practice, we developed consensus guidelines by multidisciplinary experts from international TOpCLASS consortium. Methods We performed systematic...
Immune mediated inflammatory diseases (IMIDs) are a heterogenous group of disorders joint, skin, and gut characterized by both shared distinct pathological pathways. This complexity has therapeutic implications, as not all IMIDs exhibit responsiveness to available biologicals. Moreover, cases have been documented where patients undergoing biologic therapy experience paradoxical occurrences either new IMID or flare-up previously asymptomatic one. Treatment with anti- IL-17a approved for...
Abstract Background The growing number of advanced therapies has revolutionized the management inflammatory bowel disease (IBD). Although early use biological is associated with better long-term outcomes, no data exist for Belgian population. To this end, we evaluated treatment patterns in and persistence a inception cohort. Methods PANTHER (Prognostic biobANk paTients witH Early cRohn’s or colitis) cohort consists adult IBD patients recruited 3 referral centres. Patients are included within...
Objective To compare the outcomes of different treatments for spontaneous intra‐abdominal abscesses (IAA) in active Crohn's disease (CD). Methods A retrospective analysis patients with CD between January 2007 and December 2018 was performed two Belgian inflammatory bowel centers. Successful conservative management defined as complete resolution without need resection. The primary outcome suboptimal evolution, a composite recurrence abscess, postoperative complications or non‐elective Results...