A5078834568- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Ion channel regulation and function
- Inflammatory Myopathies and Dermatomyositis
- IgG4-Related and Inflammatory Diseases
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Osteomyelitis and Bone Disorders Research
- Infectious Diseases and Tuberculosis
- Cardiac electrophysiology and arrhythmias
- Systemic Lupus Erythematosus Research
- Pericarditis and Cardiac Tamponade
- Renal Diseases and Glomerulopathies
- Atrial Fibrillation Management and Outcomes
- Nutrition and Health in Aging
- Full-Duplex Wireless Communications
- Erythrocyte Function and Pathophysiology
- Toxin Mechanisms and Immunotoxins
- Calcium signaling and nucleotide metabolism
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular and Diving-Related Complications
- Polyomavirus and related diseases
- Skin Diseases and Diabetes
- Barrier Structure and Function Studies
Yamaguchi University
2013-2025
Yamaguchi Prefecture Central Hospital
2023
Nippon Medical School
2020-2022
Objective This study investigated the effects of early treatment and pathophysiology on eosinophilic granulomatosis with polyangiitis neuropathy (EGPA-N). Methods Twenty-six consecutive patients EGPA-N were diagnosed treated within a day admission underwent clinical analysis. Peripheral nerve recovery rates evaluated after by identifying damaged peripheral through detailed neurological findings. Results The eosinophil count at onset was significantly correlated total number nerves. There...
Variable vessel vasculitis is a rare presentation of systemic vasculitis. We herein report Japanese woman with large- and small-vessel accompanied by basal cell carcinoma. The clinical course our patient suggested paraneoplastic variable Our case suggests that there are two aspects need to be considered. First, clinicians should consider cancer-related complications when treating variable-vessel Second, the evaluation vessels needed
To investigate the potential contribution of accessory respiratory muscle atrophy to decline forced vital capacity (FVC) in patients with SSc-associated interstitial lung disease (ILD).This single-centre, retrospective study enrolled 36 SSc-ILD who underwent serial pulmonary function tests and chest high-resolution CT (HRCT) simultaneously at an interval 1-3 years. The total extent ILD wall area level ninth thoracic vertebra on images were evaluated by two independent evaluators blinded...
Steroid therapy, a key therapy for inflammatory, allergic, and immunological disorders, is often associated with steroid myopathy as one of the side effects. considered first-line myositis; however, there have been no reports strictly comparing muscle mass in patients myositis before after therapy. Thus, it currently unclear whether such affects volume addition to strength. We aimed determine change via cross-sectional computed tomography (CT) myositis.Data from seven eight controls, who...
An estimated 0.9% to 2.4% of patients with systemic lupus erythematosus (SLE) also have hemophagocytic lymphohistiocytosis (HLH). HLH associated autoimmune diseases is often refractory corticosteroid treatment; thus, additional immunosuppressive drugs, such as cyclosporine, cyclophosphamide, or tacrolimus, are required. Here, we describe the case a 44-year-old Japanese woman who developed nephritis. Initially, her was treatment corticosteroid, and mizoribine. However, alternative...
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the central nervous system caused by reactivation JC virus (JCV). Typical PML shows confluent, bilateral but asymmetric, subcortical lesions in supratentorial white matter on magnetic resonance imaging (MRI). We report here 50-year-old woman with systemic lupus erythematosus complicated lymphoma who developed atypical brain MRI findings limited to infratentorial area at presentation. She presented numbness...
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A 58-year-old Japanese woman was diagnosed with anti-signal recognition particle (SRP)-positive dermatomyositis associated Sjögren's syndrome, rheumatoid arthritis and lung adenocarcinoma. She presented cutaneous lesions, including ulceration of her right middle finger. Tissue specimens obtained from deltoid muscle were positive for CD4+ T-cell infiltration the sarcolemma showed upregulation major histocompatibility complex (MHC) class I antigens. The present case suggests that overlapping...
Patients with autoimmune diseases treated corticosteroids sometimes display feelings of anxiety regarding corticosteroid use. In this single-center prospective study, we aimed to evaluate the serial changes in levels related use 18 patients diseases. The degree toward was assessed using visual analogue scale. Comprehension drug characteristics and Likert To assess patients' depression used State-Trait Anxiety Inventory. These surveys were conducted immediately before initiation therapy just...
Lupus nephritis (LN) occurs in up to 60% of systemic lupus erythematosus patients. Combination therapy involving a corticosteroid and cyclophosphamide or mycophenolate mofetil (MMF) has been standard for LN. However, clinicians generally prefer minimize steroid use LN treatment. We herein report the case Japanese man with whose severe chronic heart failure prevented us from using therapy. Instead, his was successfully treated MMF monotherapy. Based on our experience this case, we suggest...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of antineutrophil cytoplasmic antibody-associated vasculitis. Patients often present peripheral neuropathy and purpura, suggesting impairment small vessels, especially capillaries. However, medium-sized vessels vascular diameter larger than that capillaries may also be impaired, causing atypical findings. We report case EGPA treated corticosteroids, cyclophosphamide, mepolizumab. Renal biopsy revealed vasculitis the interlobular...
Diffuse alveolar haemorrhage and central nervous system vasculitis are life-threatening complications of anti-neutrophil cytoplasmic antibody-associated vasculitis. The simultaneous occurrence diffuse is a rare presentation Its diagnosis by histopathology difficult because biopsy to perform, urgent treatment needed. We report case Japanese man with associated New classification criteria may be needed for systemic When antibiotic-resistant atypical bilateral pneumonia noted in the acute phase...
Microscopic polyangiitis (MPA) affects various organs. However, echocardiographic findings of MPA are unclear. We aimed to evaluate the features acute-phase in Japanese patients.This single-centre retrospective study included 15 patients with who underwent echocardiography within 2 weeks commencing steroid therapy for induction or reinduction. The parameters thetients were compared those 30 age- and sex-matched controls.No significant differences left ventricular (LV) diameter, LV ejection...