A5087412247- Fatty Acid Research and Health
- Ion channel regulation and function
- Muscle Physiology and Disorders
- Retinal Diseases and Treatments
- Birth, Development, and Health
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Bone health and osteoporosis research
- Reproductive Biology and Fertility
- Organ Donation and Transplantation
- Adipose Tissue and Metabolism
- Neurogenetic and Muscular Disorders Research
- Peripheral Neuropathies and Disorders
- Eicosanoids and Hypertension Pharmacology
- Ubiquitin and proteasome pathways
- Advanced Glycation End Products research
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Chronic Kidney Disease and Diabetes
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Aldose Reductase and Taurine
- Calcium signaling and nucleotide metabolism
- Acute Kidney Injury Research
- Rheumatoid Arthritis Research and Therapies
Yamaguchi University
2022-2025
Kurume University
2024-2025
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness in Western and developing countries. Since antivascular endothelial growth factor (VEGF) therapy available for the regression choroidal neovascularization (CNV), it does not work pathophysiology AMD so cure increasingly demanded. Whale oil promotes various bodily functions, such as anti‐inflammatory effects cardiovascular disease, but its physiological mechanisms are still unclarified. Here, we examined whale on...
PDZ domain-containing RING finger family protein 3 (PDZRN3) is expressed in various tissues, including the skeletal muscle. Although PDZRN3 plays a crucial role terminal differentiation of myoblasts and synaptic growth/maturation myogenesis, this molecule postnatal muscles completely unknown despite its lifelong expression myofibers. In study, we aimed to elucidate function mature myofibers using myofiber-specific conditional knockout mice. After tamoxifen injection, deficiency was confirmed...
Abstract At the beginning of ovarian aging, ovulation immature oocytes is accelerated, leading to arrest despite remaining oocytes. Here, RNA expression in aging mice comprehensively analyzed during estrous cycle after stimulation. The aldo-keto reductase Akr1b7 pathway transiently activated ovaries young disappears those old mice. —/— attenuate oocyte Akt activation essential for follicular development primordial follicles, and enhanced extended because prolonged diestrous stage by a...
Abstract Dietary ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) protect against age-related macular degeneration (AMD). We here examined the effects of whale oil, which contains LCPUFAs, in a mouse model AMD. Mice were fed either diet supplemented with oil or control free LCPUFAs beginning 2 weeks before induction choroidal neovascularization (CNV) by laser photocoagulation. The area CNV measured flat-mount preparations at 7 days after photocoagulation was significantly smaller mice...