A5073670355- Lymphoma Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Immune Cell Function and Interaction
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Atherosclerosis and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Systemic Lupus Erythematosus Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cancer-related molecular mechanisms research
- Inflammation biomarkers and pathways
- Liver Diseases and Immunity
- Liver physiology and pathology
- Effects of Radiation Exposure
- Gastric Cancer Management and Outcomes
- S100 Proteins and Annexins
- Liver Disease Diagnosis and Treatment
Longyan University
2025
University of Science and Technology of China
2024
Shaanxi Normal University
2011-2024
University of California, San Diego
2024
Capital Medical University
2024
Beijing Chest Hospital
2024
Pudong New Area People's Hospital
2023-2024
Shanghai East Hospital
2023-2024
Kunming University of Science and Technology
2012-2023
First People's Hospital of Yunnan Province
2017-2023
Abstract Background Bone or brain metastases may develop in 20–40% of individuals with late‐stage non‐small‐cell lung cancer (NSCLC), resulting a median overall survival only 4–6 months. However, the primary tissue's distinctions between bone, and intrapulmonary NSCLC at single‐cell level have not been underexplored. Methods We conducted comprehensive analysis 14 tissue biopsy samples obtained from treatment‐naïve advanced patients bone ( n = 4), 6) 4) metastasis using sequencing originating...
To reveal the contribution of Irisin in beneficial effects resistance exercise on myocardial fibrosis (MF) and cardiac function mice with infarction (MI).
Abstract Exercise training (ET) is a non‐drug natural rehabilitation approach for myocardial infarction (MI). Among the numerous beneficial effects of ET, angiogenesis indispensable. In present study, we investigated role and mechanism HIF‐1α miR‐126 in ET‐induced MI which may provide new insights treatment. Rat model post‐MI human umbilical vein endothelial cells (HUVECs) were employed our research. Histomorphology, immunohistochemistry, quantitative real‐time PCR, Western blotting...
Sulfation represents a major pathway for the inactivation of steroid hormones such as estrogens and is catalyzed by group enzymes called sulfotransferases. Aberrant regulation an estrogen sulfotransferase has been demonstrated previously in livers obese diabetogenic C57BL/KsJ-db/db strain mice. In this paper, we report molecular cloning functional characterization full-length complementary DNA from mouse testis. The encodes 295 amino acids. It shares 88%, 77%, 75%, 68% identity acid sequence...
Pathological remodeling is the main detrimental complication after myocardial infarction (MI). Overproduction of reactive oxygen species (ROS) in infarcted myocardium may contribute to this process. Adequate exercise training MI reduce oxidative stress-induced cardiac tissue damage and remodeling. SET MYND domain containing 1 (Smyd1) a muscle-specific histone methyltransferase which upregulated by resistance training, strengthen sarcomere assembly myofiber folding, promote skeletal muscles...
Abstract OBJECTIVE To evaluate the effectiveness of denervation sympathectomy (RDN) and pulmonary vein isolation (PVI) for treatment hypertension combined with atrial fibrillation (AF) to examine safety procedure. METHODS Computerized retrieval clinical research papers concerning PVI RDN patients AF from databases Pubmed, Cochrane Library, EMbase, Web Science, Chinese Academic Journals (CNKI), Wanfang documented in period January 2010 April 2023 was conducted. Revman 5.3 software Stata15.1...
Background Cardiac sympathetic nerve sprouting and the dysregulation of β-adrenergic receptor (β-AR) play a critical role in deterioration cardiac function after myocardial infarction (MI). Growing evidence indicates that exercise provides protection against MI. The aims this study were to investigate whether aerobic following MI could inhibit restore balance β3-AR/β1-AR. Methods Male Sprague-Dawley rats divided into three groups: sham-operated control group (SC), (MI), with (ME). ME...
Cardiolipin (CL) plays a pivotal role in mitochondria-mediated apoptosis. Acyl-CoA: lysocardiolipin acyltransferase 1 (ALCAT1) can accelerate CL reactive oxygen production and cause mitochondrial damage. Although we have demonstrated that aerobic exercise significantly reduced ALCAT1 levels MI mice, what is the temporal characteristic of after MI? Little known. Based on this, effect rats needs to be further verified. Therefore, this paper aimed characterize expression, investigate possible...
Abstract Purpose Hepatosplenic T-cell lymphoma (HSTCL), mostly derived from γδ T cells, is a rare but very aggressive with poor outcomes. In this study, we generated the first single cell landscape for disease and characterized molecular pathogenesis underlying progression. Methods We performed paired RNA-seq receptor (TCR) sequencing on biopsies HSTCL patient pre- post- chemotherapy treatments. Following by series of bioinformatics analysis, investigated gene expression profile HSTCS as...
Background Sepsis, described as an inflammatory reaction to infection, is a very social health problem with high mortality. This study aims explore the new mechanism in progression of sepsis. Methods We downloaded GSE69528 dataset screen differentially expressed genes (DEGs) for WGCNA, which key module was identified and analyzed by DMNC algorithm, expression verification ROC curve analysis identify hub gene. Furthermore, gene immunoassay, potential neutrophils investigated vitro...
Introduction Sepsis is a common but serious disease in intensive care units, which may induce multiple organ dysfunctions such as liver injury. Previous studies have demonstrated that gamma delta (γδ) T cells play protective role sepsis. However, the function and mechanism of γδ sepsis-induced injury not been fully elucidated. IL-17A-producing are newly identified cell subtype. Methods We utilized IL-17A-deficient mice to investigate sepsis using cecum ligation puncture (CLP) model. Results...
Background T cell lymphomas (TCL) are a group of heterogeneous diseases with over 40 subtypes. In this study, we identified novel TCL subtype which was featured by unique receptor (TCR) presentation, α, β and γ chains were co-existing in single malignant cell. Case presentation A 45-year-old male patient diagnosed lymphoma after 2-month abdominal distension liver enlargement. Combining histology review, PET-CT scanning immunophenotyes, the not classified to any existing To better understand...
Abstract Clear cell adenocarcinoma of the prostate (CCPC) is a rare entity compared to acinar carcinoma (APC). The survival rate and prognostic factors CCPC are still unclear deserve further study. We downloaded data on cancer from Surveillance, Epidemiology, End Results database for 1975–2019. After inclusion exclusion criteria, we APC analyzed cancer-specific mortality (CSM) overall (OM) in patients risk using propensity score matching (PSM) study multivariate Cox regression. included...
There are no specific clinical medications that target cardiac fibrosis in heart failure (HF). Recent studies have shown tyrosine kinase inhibitors (TKIs) may benefit various organs. However, there is limited research on their application fibrosis. Axitinib, an FDA-approved inhibitor, was used to evaluate its effects and function pressure overload-induced failure.To build a pharmacological network, the targets of axitinib were first retrieved from databases coupled with key gene molecules...
Richter transformation (RT) is a rare sequelae of chronic lymphocytic leukemia (CLL)/small lymphoma (SLL). The clonal relationship the RT to underlined CLL/SLL an important prognostic factor as clonally related has worse prognosis than that unrelated RT. development more one in same patient exceedingly and prior reports have shown cases consisting diffuse large B‐cell (DLBCL) subsequent or synchronous Hodgkin lymphoma. Here, we present case first DLBCL subsequently DLBCL. Additionally,...
Immunotherapy has been a standard treatment for the patients with advanced non-small cell lung cancer (NSCLC), however, reliable biomarkers predicting response remain unclear. This study explores subpopulations of lymphocytes in bronchoalveolar lavage fluid (BALF) and combines clinical laboratory examination indicators NSCLC to identify potential related immunotherapy. A retrospective analysis was conducted on 82 locally or metastatic who underwent electronic bronchoscopy received first-line...
Background: N6-adenosine methylation (m6A) is a prevalent RNA modification associated with heart failure, alongside aberrant miRNA expression. Despite indications of miRNAs regulating m6A modification, their specific influence on in failure remains unclear. Methods: The initial analysis utilized transcriptome and sequencing data from GSE131296 mice to identify key enzymes construct an network. Integration GSE231700 revealed influencing enzymes, contributing the formation comprehensive...
Lung cancer is the second malignant tumor in world and most prevalent of respiratory system. In lung cancer, P2X7 receptor (P2X7R) an important purinergic receptor. P2X7R a class ionotropic adenosine triphosphate (ATP)-gated receptors, which exists many kinds immune tissues cells involved tumorigenesis progression. closely related to expressed at higher levels than normal tissue. plays critical regulatory function invasion migration through multiple mechanisms action affects proliferation...
Abstract Hepatosplenic T-cell lymphoma (HSTCL), mostly derived from γδ T cells, is a rare but very aggressive with poor outcomes. The molecular pathogenesis driving HSTCL largely unknown while only limited treatment options are available. In this study, by performing paired single cell RNA-seq and receptor (TCR) sequencing on biopsies patient pre- post-chemotherapy treatments, we characterized unique gene expressing signatures of malignant set marker genes were newly identified in (AREG,...