A5077446875- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Sleep and Wakefulness Research
- Pharmacological Receptor Mechanisms and Effects
- Epilepsy research and treatment
- Neurological and metabolic disorders
- Tryptophan and brain disorders
- Alcoholism and Thiamine Deficiency
- Attention Deficit Hyperactivity Disorder
- Hypothalamic control of reproductive hormones
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmacology and Obesity Treatment
- Alcohol Consumption and Health Effects
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Mental Health Research Topics
- Complementary and Alternative Medicine Studies
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
University of Utah
2021-2024
Huntsman Cancer Institute
2021-2023
Emory University
2013-2022
Icahn School of Medicine at Mount Sinai
2019
University of Miami
2017
Harvard University
2017
McLean Hospital
2017
Tulane University
2017
Emory National Primate Research Center
2007
Max Planck Institute of Psychiatry
2001
Objective: The purpose of this article was to inform the first-line treatment choice between cognitive-behavioral therapy (CBT) or an antidepressant medication for treatment-naive adults with major depressive disorder by defining a neuroimaging biomarker that differentially identifies outcomes remission and failure these interventions. Method: Functional MRI resting-state functional connectivity analyses using bilateral subcallosal cingulate cortex (SCC) seed applied 122 patients from...
Limited controlled data exist to guide treatment choices for clinicians caring patients with major depressive disorder (MDD). Although many putative predictors of response have been reported, most were identified through retrospective analyses existing datasets and very few replicated in a manner that can impact clinical practice. One confound previous studies examining is the patient's history, which may affect both predictor interest outcomes. Moreover, prior history provides an important...
The Predictors of Remission in Depression to Individual and Combined Treatments [PReDICT] study aimed identify clinical biological factors predictive treatment outcomes major depressive disorder among treatment-naive adults. authors evaluated the efficacy cognitive-behavioral therapy (CBT) two antidepressant medications (escitalopram duloxetine) patients with depression examined moderating effect patients' preferences on outcomes.Adults aged 18-65 were randomly assigned equal likelihood 12...
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions individuals worldwide. While rare genetic variants play role in the etiology schizophrenia, most currently explained liability within common variation, suggesting that variation predating human diaspora out Africa harbors large fraction variant attributable heritability. However, association studies schizophrenia have concentrated mainly on cohorts European descent. We describe...
The authors tested the hypothesis that concentrations of pain-transmitting neuropeptide substance P are elevated in CSF patients with major depression or posttraumatic stress disorder (PTSD), which have overlapping symptoms. also sought to determine if CNS change on provocation symptoms PTSD patients.The measured medication-free either and healthy comparison subjects. Next, using a within-subject, crossover design, sampled for 6 hours through an indwelling subarachnoid catheter before,...
BACKGROUND Cancer‐related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, yet treatment options for CRF are limited. In this study, we evaluated the efficacy of weekly Swedish massage therapy (SMT) versus an active control condition (light touch [LT]) waitlist (WLC) on persistent in breast survivors. METHODS This early phase, randomized, single‐masked, 6‐week investigation SMT, LT, WLC enrolled 66 female stage 0‐III survivors (age range, 32‐72 years)...
To compare 2 omega-3 (n-3) preparations enriched with eicosapentaenoic acid (EPA) versus docosahexaenoic (DHA) as monotherapy for major depressive disorder (MDD) in a 2-site, placebo-controlled, randomized, double-blind clinical trial.196 adults (53% female; mean [SD] age = 44.7 [13.4] years) DSM-IV MDD and baseline 17-item Hamilton Depression Rating Scale (HDRS-17) score ≥ 15 were randomized equally from May 18, 2006, to June 30, 2011, 8 weeks of treatment oral EPA-enriched n-3 1000 mg/d,...
Adults with major depressive disorder frequently do not achieve remission an initial treatment. Addition of psychotherapy for patients who antidepressant medication alone can target residual symptoms and protect against recurrence, but the utility adding after nonremission cognitive-behavioral therapy (CBT) has received little study. The authors aimed to evaluate acute long-term outcomes resulting from both sequences combination treatments.Previously untreated adults depression were randomly...
Objective: This study compared the impact of 3 eicosapentaenoic acid (EPA) doses versus placebo on inflammatory biomarkers and depressive symptoms.Methods: Sixty-one unmedicated adults (75% female; 45.5 ± 13.8 years) with DSM-5 major disorder (MDD), body mass index > 25 kg/m2, plasma high-sensitivity C-reactive protein (hs-CRP) ≥ 3.0 mg/L were randomly assigned to receive EPA 1 g/d, 2 or 4 g/d for 12 weeks. Prespecified endpoints a 0.40 effect size decrease in interleukin (IL)-6, peripheral...
Abstract Chronic inflammation has been implicated in the pathophysiology of major depressive disorder (MDD). Activating resolution through ω-3 fatty acid supplementation may prove to be a successful therapeutic strategy for treatment MDD. Patients with MDD, body mass index >25 kg/m 2 , and plasma high-sensitivity C-reactive protein ≥3 μg/mL ( n = 61) were enrolled 12-week randomized trial consisting 4 parallel arms: EPA 1, 2, g/d, placebo. The supplement contained DHA 3.9:1 ratio....
Objective: The authors tested the hypothesis that concentrations of pain-transmitting neuropeptide substance P are elevated in CSF patients with major depression or posttraumatic stress disorder (PTSD), which have overlapping symptoms. also sought to determine if CNS change on provocation symptoms PTSD patients. Method: measured medication-free either and healthy comparison subjects. Next, using a within-subject, crossover design, sampled for 6 hours through an indwelling subarachnoid...
Posttraumatic stress disorder (PTSD) is associated with altered concentrations of stress-related neurohormones, neurotrophins, and neuropeptides in plasma serum; however, few studies have examined central alterations these measures individuals PTSD. Furthermore, no study to date has evaluated the effects successful antidepressant treatment on cerebrospinal fluid (CSF) abnormalities PTSD.Sixteen medication-free outpatients chronic PTSD (Diagnostic Statistical Manual Mental Disorders, Fourth...
This article reviews the role of massage therapy in treatment common psychiatric disorders and briefly discusses prevalence popularity complementary integrative treatments general population touches on literature biology neurobiology therapy.
Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main measures, including DNA methylation (DNAm), are inconsistent. Studies in perinatal tissues indicate that variability DNAm at birth is best explained by joint genotype and prenatal environment. Here, we extend these analyses postnatal stressors. We investigated contribution CA, cis (G), their additive (G +...