A5063617462- Cardiac Arrest and Resuscitation
- Genetic Mapping and Diversity in Plants and Animals
- Neonatal and fetal brain pathology
- Adipose Tissue and Metabolism
- Traumatic Brain Injury Research
- Neuroscience of respiration and sleep
- Genetic and phenotypic traits in livestock
- Gut microbiota and health
- Animal Nutrition and Physiology
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
- Traumatic Brain Injury and Neurovascular Disturbances
University of Michigan
2023-2025
Michigan State University
2021-2023
Addiction vulnerability is associated with the tendency to attribute incentive salience reward predictive cues. Both addiction and attribution of are influenced by environmental genetic factors. To characterize contributions attribution, we performed a genome-wide association study (GWAS) in cohort 1596 heterogeneous stock (HS) rats. Rats underwent Pavlovian conditioned approach task that characterized responses food-associated stimuli ("cues"). Responses ranged from cue-directed...
The intestinal microbiome influences health and disease. Its composition is affected by host genetics environmental exposures. Understanding genetic effects critical but challenging in humans, due to the difficulty of detecting, mapping interpreting them. To address this, we analysed four cohorts outbred laboratory rats exposed distinct controlled environments. We found that polygenic were consistent across identified three replicated microbiome-associated loci. One involved a...
A vexing observation in genome-wide association studies (GWASs) is that parallel analyses different species may not identify orthologous genes. Here, we demonstrate cross-species translation of GWASs can be greatly improved by an analysis co-localization within molecular networks. Using body mass index (BMI) as example, show the genes associated with BMI humans lack significant agreement those identified rats. However, networks interconnecting these substantial overlap, highlighting common...
Abstract Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal address pathophysiological mechanisms and biomechanics associated with head injuries. Understanding cognitive, motor, sensory aspects of behavior throughout development is crucial for evaluating cognitive motor deficits after injury. We have developed comprehensive battery tests characterize...
Abstract Genome-wide association studies typically evaluate the autosomes and sometimes X Chromosome, but seldom consider Y or mitochondrial (MT) Chromosomes. We genotyped MT Chromosomes in heterogeneous stock (HS) rats (Rattus norvegicus), an outbred population created from 8 inbred strains. identified distinct 4 among founders. However, only 2 types of each nonrecombinant chromosome were observed our modern HS rat (generations 81–97). Despite relatively large sample size, there virtually...
Abstract Brain injuries that are induced by external forces particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal address pathophysiological mechanisms and biomechanics associated with head injuries. Understanding cognitive, motor, sensory aspects of behavior throughout development is crucial for evaluating cognitive motor deficits after injury. We have developed comprehensive battery tests characterize...
The goal of this work is to identify MRI biomarkers mild traumatic brain injury (mTBI) using a pig model pediatric concussion. We have found changes in the DTI and fMRI days weeks immediately following injury. also collected data from battery cognitive, emotional, motor assessments. Together, we anticipate these will help us that improve diagnostics children decrease risk post-injury complications.