A5002005518- Nutritional Studies and Diet
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Phytoestrogen effects and research
- Dietary Effects on Health
- Diet, Metabolism, and Disease
- Circadian rhythm and melatonin
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Immunotherapy and Immune Responses
- Muscle metabolism and nutrition
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Cell Adhesion Molecules Research
- vaccines and immunoinformatics approaches
- Radiopharmaceutical Chemistry and Applications
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Digestive system and related health
- Cardiovascular Disease and Adiposity
- Nuts composition and effects
- Gastrointestinal motility and disorders
- Eating Disorders and Behaviors
- Sleep and related disorders
- Climate Change and Health Impacts
University Hospital Cologne
2022-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2023-2024
University of Cologne
2022-2024
Düsseldorf University Hospital
2022-2024
Heinrich Heine University Düsseldorf
2022-2024
German Center for Infection Research
2023
Maastricht University
2018-2023
University Medical Center
2019-2022
Diabetes Australia
2021
Maastricht University Medical Centre
2018-2020
Intestinal barrier function is suggested to decrease with aging and may be improved by pectin intake. The aim of this study was investigate the effects four weeks supplementation on gastrointestinal in vivo ex different age groups. In a randomized, double-blind, placebo-controlled, parallel study, 52 healthy young adults (18-40 years) 48 elderly (65-75 received 15 g/day or placebo for weeks. Pre- post-intervention, permeability multisugar test, defense capacity mucosal samples were assessed....
Weight loss has been associated with adaptations in energy expenditure. Identifying factors that counteract these are important for long-term weight and maintenance. The aim of this study was to investigate whether increased protein/carbohydrate ratio would reduce adaptive thermogenesis (AT) the expected positive balance (EB) during maintenance after participants prediabetes postobese state. In 38 participants, effects 2 diets differing on expenditure respiratory quotient (RQ) were assessed...
BackgroundSoy foods may contribute to the beneficial health effects of healthy plant-based diets on risk develop cardiovascular disease (CVD). However, their vascular function have hardly been studied.ObjectiveTo investigate longer-term soy nut consumption and cardiometabolic markers in older men women.DesignTwenty-three participants (age: 60–70 years; BMI: 20–30 kg/m2) participated a randomized, controlled, single-blinded cross-over trial with an intervention (67 g/day nuts providing 25.5 g...
Effects of soy foods on cerebral blood flow (CBF)—a marker cerebrovascular function—may contribute to the beneficial effects plant-based diets cognitive performance. We aimed investigate longer-term nut consumption CBF in older adults. Changes 3 different domains performance were also studied. Twenty-three healthy participants (age: 60–70 y; BMI: 20–30 kg/m2) participated a randomized, controlled, single-blinded crossover trial with an intervention (67 g/d nuts providing ∼25.5 g protein and...
Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body management have been shown. To extend these findings, associations between perception hunger and satiety with endocannabinoids, glucagon-like peptide-1 (GLP-1) polypeptide YY (PYY) were assessed. At approximately 34 months loss, 22 female 16 male participants (mean age 64.5 ± 5.9 years; mass index (BMI) 28.9 3.9 kg/m2) completed 48 h respiration chamber study. Participants fed in energy balance...
Vaccination remains crucial for protection against severe SARS-CoV-2 infection, especially people of advanced age, however, optimal dosing regimens are as yet lacking.
Abstract Background In the ongoing COVID-19 pandemic, advanced age is a risk factor for severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and research should focus on optimal vaccination schedules. addition to each individual’s medical history, immunosenescence warrants further this population. This study investigates vaccine-induced immune response over 1 year. Methods/design EU-COVAT-1-AGED randomised...
Endocannabinoids are suggested to play a role in energy balance regulation.We aimed investigate associations of endocannabinoid concentrations during the day with and adiposity interactions 2 diets differing protein content participants postobese phase prediabetes.Participants (n = 38) were individually fed medium (MP: 15:55:30% from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% P:C:F) for 48 hours respiration chamber.Associations between balance, expenditure, respiratory...
An unfavorable lipid profile and being overweight are known mediators in the development of cardiovascular disease (CVD) risk. The effect diet, particularly high protein, remains under discussion. Therefore, this study examines effects a high-protein (HP) diet on cardiometabolic health vascular function (i.e., endothelial function, arterial stiffness, retinal microvascular structure), possible association with plasma endocannabinoids endocannabinoid-related compounds participants....
Abstract Objective The aim of this study was an assessment post hoc associations among circadian rhythm parameters, physical activity (PA), and cardiometabolic risk factors in adults with obesity prediabetes after 3 years weight loss maintenance. Methods Circadian parameters (continuous wrist‐temperature measurements), PA, systolic diastolic blood pressure (SBP, DBP), heart rate (HR), plasma high‐density lipoprotein cholesterol (HDL‐C), low‐density cholesterol, remnant triacylglycerol,...
Abstract Background Vaccination remains crucial for protection against severe SARS-CoV-2 infection, especially in aged population. Methods We evaluated, with a randomised controlled, adaptive, multicentre phase II study, the safety and immunogenicity of 3rd vaccination dose (1st booster) individuals ≥75 years (ClinicalTrials.gov Identifier: NCT05160766, EudraCT Number: 2021-004526-29). Participants were randomized to either full-dose (100µg) mRNA-1273 (Spikevax®) or 30 µg BNT162b2...
Effects of plant-based diets on cerebral blood flow (CBF), which is a physiological marker cerebrovascular function, have hardly been studied and may contribute to the beneficial effects these cognitive performance. Therefore, primary objective this study was investigate longer-term soy nut consumption CBF in older men women. Changes performance were also studied. A randomized, controlled, cross-over trial performed with sixteen-week intervention period, separated by wash-out period eight...
Background: Booster vaccination for the elderly provides protection from severe SARS-CoV-2 infection, however data is still limited on optimal timing, dosing and immunogenicity in this population.Methods: EU-COVAT-1-AGED Part B a randomised controlled, adaptive, multicentre, phase II trial evaluating safety of 4th (2nd booster) individuals ≥75 years. Participants were to receive either BNT162b2 (Comirnaty®, 30µg) or mRNA-1273 (Spikevax®, 100µg). The primary endpoint was rate 2-fold antibody...
Abstract Background: In the ongoing COVID-19 pandemic, advanced age is a risk factor for severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and research should focus on optimal vaccination schedules. addition to each individual’s medical history, immunosenescence warrants further this population. This study investigates vaccine-induced immune response over one year. Methods/Design: EU-COVAT-1-AGED randomised...
Soy foods may contribute to the beneficial effects of plant-based diets on cardiovascular disease (CVD) risk. However, their vascular function have hardly been investigated. The objective was investigate if longer-term soy nut consumption improves and cardiometabolic health in older adults. Twenty-three apparently healthy participants (60–70 years; BMI between 20–30 kg/m2) participated a randomized, controlled, single-blinded cross-over trial with an intervention (67 g nuts daily providing...