A5047798683- Dermatologic Treatments and Research
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Allergic Rhinitis and Sensitization
- Wound Healing and Treatments
- Reconstructive Facial Surgery Techniques
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Hair Growth and Disorders
- Nonmelanoma Skin Cancer Studies
- Chemotherapy-related skin toxicity
- Cutaneous Melanoma Detection and Management
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Reconstructive Surgery and Microvascular Techniques
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Oral Health Pathology and Treatment
- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Surgical Sutures and Adhesives
- Laser Applications in Dentistry and Medicine
- Skin and Cellular Biology Research
- Medicine and Dermatology Studies History
- melanin and skin pigmentation
Goethe University Frankfurt
2015-2024
University Hospital Frankfurt
2014-2024
Klinikum im Friedrichshain
2024
Johannes Gutenberg University Mainz
2024
Klinikum Lippe
2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2024
Bundeswehr Joint Medical Service
2024
Universität Hamburg
2014
Goethe Institute
2007-2011
Abstract Numerous comorbidities and cofactors have been known to influence wound healing processes. In this multicentre study, clinical data of 1 000 patients with chronic leg ulcers from ten specialised dermatological care centers were analysed. The patient cohort comprised 567 females 433 males an average age 69·9 years. wounds persisted on for 40·8 months had a mean size 43·7 cm 2 . Venous represented the most common entity accounting 51·3% all wounds, followed by mixed‐type in 12·9%...
Summary Background In almost every chronic wound different bacteria species can be detected. Patients and methods Retrospective, multicenter evaluation of bacterial swab results from 2010 2011 in patients with leg ulcer treated 10 dermatologic care centers 5 regions Germany. Results Data 970 were analyzed. Staphylococcus aureus was detected 47.6 % the patients, 8.6% these methicillin‐resistant (MRSA). Pseudomonas aeruginosa found 31.1 %, enterobacteria 28.6 Proteus mirabilis 13.7 patients....
Summary This S2k guideline on venous leg ulcers was created the initiative and under leadership of German Society Phlebology Lymphology (DGPL). The group also consisted representatives from for Lymphology, Dermatological Society, General Medicine, Angiology, Vascular Surgery Surgery, Dermatosurgery, Wound Healing Treatment, Professional Association Phlebologists Lymphologists Initiative Chronische Wunden. aim this is to combine different approaches levels knowledge respective professional...
Hidradenitis suppurativa (HS) is a chronic debilitating skin disease in inverse body areas. Wide excision recommended Hurley Stages II to III, but the rate and symptoms of recurrences long-term follow-up remain unclear.To analyze allocation regarding operative field, onset quality HS as well factors associated with follow-up.Forty-eight patients Stage III who had undergone 91 wide excisions from 2010 2015 were clinically examined postoperative complications recurrences. To determine risk...
Background: Ataxia telangiectasia (A-T) is a devastating multi-system disorder characterized by progressive cerebellar ataxia, growth retardation, immunodeficiency, chronic pulmonary disease and chromosomal instability. Cutaneous granulomas are known phenomenon in A-T but extra-dermal manifestation of at bone synovia has not been reported so far. The clinical presentation, immunological findings, the long-term course treatment options eight patients with severe will be reported. Methods:...
The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect are scarce.In present in vitro study, we compared culture media supplemented (a) thermal (La Roche-Posay, Avène) and (b) two natural mineral drinking (Heppinger, Adelholzener) on physiological parameters HaCaT keratinocytes.The medium preparations were investigated regard cell proliferation damage....
Optimizing the treatment regimens of extensive or nonhealing defects is a constant challenge. Tissue-cultured skin autografts may be an alternative to mesh grafts and keratinocyte suspensions that are applied during surgical defect coverage.Autologous epidermal dermal cells were isolated, in vitro expanded seeded on collagen-elastin scaffolds. The developed autograft was immunohistochemically electron microscopically characterized. Subsequently, it transplanted onto lesions severely burned...
Abnormalities of the major histocompatibility complex (MHC) antigens by tumour cells impair cellular immune response and promote evasion from surveillance. So far, studies analysing MHC class II expression levels in head neck cancer have been limited.Therefore, we investigated constitutive interferon (IFN)-gamma-regulated profiles antigen processing machinery (APM) various cell lines also analysed lesions.Using immunohistochemistry, flow cytometry, reverse transcriptase-polymerase chain...
Abstract Background Adipose‐derived stem cells ( ASC ) are known to transdifferentiate into a wide range of different cell species in vitro including along the epidermal lineage. This property makes them promising tool for regenerative medicine restore barrier. Objective study is dedicated identify conditions enabling transdifferentiation keratinocyte‐like phenotype. In particular, impact culture (media compositions, 2D, 3D cultures) and extracellular matrix ECM molecules was evaluated....
Recent evidence suggests that dimethylfumarate (DMF), known as a highly potent anti-psoriatic agent, might have anti-tumorigenic properties in melanoma. It has recently been demonstrated DMF inhibits melanoma proliferation by apoptosis and cell cycle inhibition therefore metastasis. Nonetheless, the underlying mechanisms remain to be evaluated. To elucidate effects of on lines (A375, SK-Mel), we first performed cytotoxicity assays. No significant lactatedehydogenase (LDH) release could...
Current literature is inconsistent regarding the risk of severe side effects using accelerated induction protocols in Hymenoptera venom immunotherapy (VIT). In addition, several data indicate influence purity grade preparation on tolerability. We evaluated safety and tolerability ultra-rush rush build-up purified non-purified preparations.Retrospective single-center study 581 VIT inductions (325 256 protocols) from 2005 to 2018 559 patients with bee vespid allergy aqueous (ALK SQ®) for...
A high proportion of house dust mite (HDM)-allergic asthmatics suffer from both an early asthmatic reaction (EAR) and a late (LAR) which follows it. In these patients, allergic inflammation is more relevant. MiRNAs have been shown to play important role in the regulation asthma's pathology. The aim this study was analyze miRNA profile patients with mild asthma HDM allergy after bronchial allergen provocation (BAP). Seventeen EAR/no LAR 17 EAR plus LAR, determined by significant fall FEV1...
Zusammenfassung Diese S2k‐Leitlinie zu den Thematiken des Ulcus cruris venosum wurde auf Initiative und unter Federführung der Deutschen Gesellschaft für Phlebologie Lymphologie (DGPL) e.V. erstellt. Die Leitliniengruppe bestand zudem aus Vertretern Lymphologie, Dermatologische Gesellschaft, Allgemeinmedizin, Angiologie, Gefäßchirurgie Gefäßmedizin, Chirurgie, Dermatochirurgie, Deutsche Wundheilung Wundbehandlung, Berufsverband Phlebologen Lymphologen Chronische Wunden. Durch diese Leitlinie...