A5100632212- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Microbial Metabolites in Food Biotechnology
- Veterinary medicine and infectious diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Advanced Radiotherapy Techniques
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Phytochemistry and Bioactive Compounds
- Medical Research and Treatments
- Plant tissue culture and regeneration
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Gastrointestinal disorders and treatments
- Invertebrate Immune Response Mechanisms
- RNA Interference and Gene Delivery
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Beijing Jishuitan Hospital
2024
Capital Medical University
2024
Qingdao University
2022-2024
Qingdao Women and Children's Hospital
2022-2024
Affiliated Hospital of Nantong University
2023-2024
Nantong University
2023-2024
Dalian Ocean University
2023-2024
Chengdu Women's and Children's Central Hospital
2022-2023
Helicobacter pylori (H. pylori) eradication is pivotal for alleviating gastric mucosal inflammation and preventing the progression of diseases. While antibiotic-based therapies have achieved significant success in H. eradication, challenges such as antibiotic resistance, drug toxicity, side effects, nonadherence, inapplicability, disruption gastrointestinal microflora emerged. Updated are urgently needed to suppress pylori. Nature has provided multitudinous therapeutic agents since ancient...
Gastric cancer is an important cause of death worldwide with Helicobacter pylori (H. pylori) considered a leading and known risk factor for its development. More particularly despite the underlying mechanisms not being very clear, studies have revealed that H. cytotoxin-associated gene A (CagA) protein plays key role in this process. In study it was found increased expression miR-543 human gastric tissue when compared pylori-negative samples. vitro experiments showed induced by CagA strong...
Abstract Purpose The use of volumetric modulated arc therapy (VMAT), simultaneous integrated boost (SIB), and hypofractionated regimen requires adequate patient setup accuracy to achieve an optimal outcome. purpose this study was assess the patients receiving left‐sided breast cancer radiotherapy using deep inspiration breath‐hold technique (DIBH) surface guided (SGRT) calculate corresponding margins. Methods between within fractions measured by comparing 6DOF shifts made SGRT system AlignRT...
Chronic inflammation plays a pivotal role in the development of frailty patients with cardiovascular diseases (CVD). Systemic inflammatory response index (SIRI) has been shown to reflect overall status. This study aimed investigate relationship between SIRI and older CVD, develop nomogram for predicting risk this population. A total 234 CVD were included. Inflammation markers derived from routine blood tests, status was assessed using FRAIL scale. Clinical laboratory characteristics compared...
Abstract To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most them are classified into benign or unidentified alterations due to their undetectable phenotypes. Whether how they could cause tumors remains unknown, this significantly limits diagnosis therapy. Here, in study family with hereditary cancer, we find that two BARD1 mutations, P24S R378S, simultaneously exist cis surviving Neither the single causes functional change, but...
Abstract Background Colorectal cancer (CRC) is the second most common cause of cancer‐related death worldwide. Long noncoding RNA (lncRNA) involved in many malignant tumors. This study aimed to clarify role lncRNA plasmacytoma variant translocation 1 (PVT1) CRC growth and metastasis. Methods Differentially expressed lncRNAs were analyzed using Cancer Genome Atlas. Gene expression profiling interactive analysis a comprehensive resource for from arrays databases used analyze PVT1 prognosis,...
Helicobacter pylori is a major cause of gastric cancer. This study was aimed to explore the characteristic DNA damage induced by H. infection in cancer AGS cells. After with pylori, reactive oxygen species (ROS) levels cells were significantly higher than those uninfected Cells longer comet tails detected after pylori. The number apurinic/apyrimidinic endonuclease 1- and phosphorylated H2AX-positive increased compared negative control expression pChk1 pChk2 upregulated infection. Cell growth...
Gastric cancer is still a common worldwide. Investigation of potential plasma biomarkers for gastric diagnosis essential prevention strategies and early intervention cancer-control planning.This study was aimed to explore the lncRNAs' promoter CDKN1A antisense DNA-damage-activated RNA (PANDAR), FOXD2-AS1, SMARCC2 as novel diagnostic cancer.109 patients 106 healthy controls were involved in this study. Plasma lncRNAs PANDAR, detected by real-time PCR. Student's t-test, Mann-Whitney U test,...
Recent studies have shown that gastrokine 1 (GKN1), an important tumor suppressor gene, is downregulated in Helicobacter pylori (H. pylori) infected gastric mucosa and cancer. However, the underlying mechanism poorly understood. Herein, we investigated potential of H. pylori-induced GKN1 downregulation.GKN1 AU-rich element RNA-binding factor (AUF1) expressions were assessed by quantitative real-time PCR, Western blot, or immunohistochemistry pylori-infected tissues co-cultured cell lines....
Abstract In this article, a compact broadband rectifying antenna (rectenna) is proposed to harvest RF energy. A novel Vivaldi presented and an efficient rectifier with single stub matching network designed. Simulation experiment have been performed good convergence observed between the simulated measured results. The experimental results show that features broad bandwidth from 2.3 GHz 2.85 maximum conversion efficiency of up 68% at 0 dBm. output voltage rectenna are 58% 1.6 V 2.45 under input power
Abstract Background CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) plays an important role in cancer development. Although Helicobacter pylori ( H. ) infection is a main cause of gastric cancer, the function CMTM3 during remains unclear. expression levels tissues from pylori- infected patients and cells co-cultured with were analyzed. qRT-PCR ELISA used to investigate effects on interleukin 8 (IL-8) expression. Annexin V/propidium iodide staining was performed evaluate apoptosis...
CagA, a virulence factor of Helicobacter pylori (H. pylori), is known to drive inflammation in gastric epithelial cells and typically degraded through autophagy. However, the molecular mechanism by which CagA evades autophagy-mediated degradation remains elusive. This study found that H. inhibits autophagic flux upregulating expression AU-rich element RNA-binding 1 (AUF1). We confirmed AUF1 does not affect autophagy initiation but instead hampers lysosomal clearance, as evidenced treatments...