A5100442690- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Traffic Prediction and Management Techniques
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Hydraulic and Pneumatic Systems
- CRISPR and Genetic Engineering
- Innovative concrete reinforcement materials
- Traffic control and management
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Advanced Sensor and Control Systems
- Cancer Research and Treatments
- Fungal Biology and Applications
- Extracellular vesicles in disease
- Kruppel-like factors research
- Plant Gene Expression Analysis
- Forecasting Techniques and Applications
- Steroid Chemistry and Biochemistry
- IL-33, ST2, and ILC Pathways
- Polysaccharides and Plant Cell Walls
- Adaptive Control of Nonlinear Systems
- Human Health and Disease
- Environmental Impact and Sustainability
- Electromagnetic Launch and Propulsion Technology
Anhui Medical University
2021-2025
Guangxi University
2025
Tongji University
2025
Xuzhou Medical College
2025
Dalian Medical University
2024
Peking University
2021-2024
Zhejiang University
2017-2024
Beijing Jishuitan Hospital
2024
Capital Medical University
2024
Langfang Normal University
2022
Abstract Allogeneic immune rejection is a major barrier for the application of human pluripotent stem cells (hPSCs) in regenerative medicine. A broad spectrum cells, including T natural killer (NK) and antigen-presenting which either cause direct cell killing or constitute an immunogenic environment, are involved allograft rejection. strategy to protect donor from cytotoxicity while decreasing secretion inflammatory cytokines lymphocytes still lacking. Here, we engineered hPSCs with no...
Chikungunya virus (CHIKV) is an arbovirus that can lead to chronic arthritis and significantly diminish the quality of life patients. Given expanding global prevalence CHIKV absence specific antiviral therapies, there urgent need explore effective treatment options. This study aimed evaluate effects shikimic acid (SA) against through a combination network pharmacology, molecular docking, in vitro assays. Network pharmacology analysis identified 26 potential targets which SA could inhibit...
The purpose of this study is to present a new method for lane‐based traffic demand estimation using travel times from video‐imaging detectors. overcomes the following two shortcomings loop‐detector‐based algorithms: fact that actual unknown when detectors are located upstream stop lines within short distance; and difficulty in calculating ratio between streams different lane groups if at upper reaches links. First, authors analyse variety time patterns introduce concept virtual cycle...
Abstract Forecasting daily traffic flow in the future is one of most critical components management to improve operational efficiency. This article aims address forecasting problem given historical data. Because pattern strongly correlated with contextual factors, we propose a match‐then‐predict method which integrates matching and time series prediction based on group data handling (GMDH) algorithm. From Seattle‐based case study, show that can significantly accuracy. We also proposed...
Abstract To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most them are classified into benign or unidentified alterations due to their undetectable phenotypes. Whether how they could cause tumors remains unknown, this significantly limits diagnosis therapy. Here, in study family with hereditary cancer, we find that two BARD1 mutations, P24S R378S, simultaneously exist cis surviving Neither the single causes functional change, but...
A significant impediment persists in developing multicomponent nanomedicines designed to dismantle the heat shock protein (HSP)-based protective mechanism of malignant tumors during photothermal therapy. Herein, well-defined PEGylated phospholipid micelles were utilized coencapsulate quercetin (QUE, a natural anticancer agent and potent HSP inhibitor) indocyanine green (ICG, agent) with aim achieving synchronized synergistic drug effects. The subsequent investigations validated that tailored...
The rapid expansion of built-up land has disrupted carbon dynamics, intensifying climate instability. Understanding how green and grey infrastructure patterns influence emissions is crucial, yet most analyses either treat them separately or overlook local-scale spatial heterogeneity. This study adopts "village units" as the minimum planning adjustment unit to explore integrated green-grey cover (IGGI-LCP) affect net emission intensity (NCEI). Using eight village units in Zhejiang Province,...
Abstract Allostatic load (AL) is a comprehensive physiologic measure of the body's chronic stress response and associated with physical mental health risks. The function DASH diet (Dietary Approaches to Stop Hypertension) model in development AL unclear. relationship between score was examined this study. 1,565 US adults from NHANES database 2017–2020 were selected for study, dietary pattern assessed using score, ≥4.5 indicated compliance diet. calculated 11 biomarkers, >3 high levels....
The change in temperature will the composition of intestinal microorganisms juvenile Eriocheir sinensis, and affect growth development crabs. In order to explore relationship between E. sinensis at different temperatures, status microflora reared water temperatures (15 °C, 23 30 °C) were compared this study. results showed that respective survival rate three groups was 100%, 87.5%, 64.44%. Moreover, molting increased with an increase temperature, which 0%, 10%, 71.11% for groups. average...
Polyplexes are required to be equipped with multiple functionalities accomplish adequate structure stability and gene transfection efficacy for therapy. Herein, a 4-carboxy-3-fluorophenylboronic acid (FPBA)-functionalized block copolymer of PEG-
Transregional energy transmission can help balance resource allocation and serve long-term regional interests. The West–East Gas Pipeline Project (WEGPP), which is the longest natural gas pipeline in China, aims to address serious imbalance between supply demand China's eastern western regions. Few studies have considered WEGPP's effect on carbon emissions terms of transmission. Using data for prefecture-level cities from 2000 2019, we consider WEGPP as a quasi-natural experiment adopt...
Gordonia neofelifaecis NRRL B-59395 was initially isolated from the fresh feces of a clouded leopard based on its ability to degrade cholesterol. The transcriptome profiles G. grown with cholesterol, androstenedione (AD), and pyruvic acid were compared by RNA-Seq. sterol catabolic genes are highly conserved in neofelifaecis, Rhodococcus jostii RHA1, Mycobacterium tuberculosis. RNA-Seq results indicated that involved side chain cleavage exclusively induced while degradation rings A/B C/D...
The application of nucleic acids as therapeutic agents has been obstructed by the lack efficient and safe systems for delivery DNA into target cells. Nanoparticle (NP) vectors based on biocompatible biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) polymers, especially PEGylated ones, seem to be promising drug but are far from being ideal gene systems. Given broad potential PLGA (PEG-PLGA) NPs in biomedical applications, here, we designed optimized a PEG-PLGA NP system incorporating...
Abstract In this study, the application of near‐infrared (NIR) spectroscopy for online monitoring Moluodan extraction process was investigated. Paeoniflorin, main active component Moluodan, chosen as quality index. Samples were partitioned into calibration and validation sets by random select set partitioning based on joint X‐Y distances algorithm (SPXY), respectively. Wavelengths modeling selected manual method competitive adaptive reweighted sampling (Cars) algorithm. Particle swarm...
The NLRP3 inflammasome is associated with a variety of human diseases, including cryopyrin-associated periodic syndrome (CAPS). CAPS dominantly inherited disease missense mutations. Currently, most studies on the NLRP3-inflammasome have been performed mice, but activation patterns and signaling pathways mouse are not always identical those in humans. pigs similar to that Therefore, precise NLRP3-point mutations may model more accurately. In this study, an gain-of-function pig carrying...
useful tools for population genetic studies, individual