A5101895237- Intracerebral and Subarachnoid Hemorrhage Research
- Myasthenia Gravis and Thymoma
- Histone Deacetylase Inhibitors Research
- Kruppel-like factors research
- Acute Ischemic Stroke Management
- Spinal Hematomas and Complications
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- CAR-T cell therapy research
- Plant-based Medicinal Research
- Renin-Angiotensin System Studies
- Blood Coagulation and Thrombosis Mechanisms
- Neurosurgical Procedures and Complications
- Glycogen Storage Diseases and Myoclonus
- Ophthalmology and Eye Disorders
- Macrophage Migration Inhibitory Factor
- Neurological disorders and treatments
- Epilepsy research and treatment
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Neurotransmitter Receptor Influence on Behavior
- Autoimmune Neurological Disorders and Treatments
- Galectins and Cancer Biology
- Psoriasis: Treatment and Pathogenesis
- Inflammation biomarkers and pathways
Xuzhou Medical College
2012-2025
Affiliated Hospital of Xuzhou Medical College
2012-2022
University of Macau
2015
Abstract Cancer cells rely on glycolysis to maintain high levels of anabolism. However, the metabolism glucose via in cancer is frequently incomplete and results accumulation acidic metabolites such as pyruvate lactate. Thus, have develop strategies alleviate intracellular acidification pH stability. We report here that glutamine consumption by has an important role releasing pressure associated with cell growth. found ammonia produced during glutaminolysis, a dominant pathway, critical...
Abstract Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection many disorders, including stroke. However, the mechanism by which HDAC6 inhibition protects neurons after remains unclear. Here, we discovered that genetic ablation or pharmacological of reduced brain injury increasing macrophage migration inhibitory factor (MIF) acetylation. Mass spectrum analysis and...
Abstract Background Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major contributing to high mortality of intracerebral haemorrhage (ICH). Nucleotide-binding oligomerization domain 1 (NOD1)/receptor-interacting protein 2 (RIP2) signalling has been reported participate in inflammatory response. Therefore, we investigated role NOD1/RIP2 mice with collagenase-induced ICH cultured primary microglia challenged hemin. Methods...
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated neurological inflammatory disease. As a G protein-coupled receptor, formyl peptide receptor 2 (FPR2) orchestrates innate and adaptive immunity. Yet the precise role of FPR2 in neuroinflammation poorly understood. Methods: Peripheral blood samples were collected from patients with NMOSD healthy controls. Single-cell RNA sequencing (scRNA-seq) flow cytometry employed to assess expression immune cell subsets. We...
IL-17 and IL-22 are implicated in the pathogenesis of autoimmune diseases. The roles pathophysiology myasthenia gravis (MG) remain unsettled. aim this study was to investigate possible relationship between serum IL-22, levels, anti-acetylcholine receptor antibody (anti-AChR Ab) titres clinical parameters patients with MG. levels anti-AChR Ab were tested by enzyme-linked immunosorbent assay (ELISA), while expression mRNAs peripheral blood mononuclear cells (PBMC) from healthy MG subjects...
Studies have shown that thrombin activation played a central role in cell injuries associated with intracerebral hemorrhage (ICH). Here, our study investigated the cytotoxicity of on neurons, and determined involvement JNK pathways thrombin-induced neuronal apoptosis. Primary cultured neurons were treated different doses thrombin. Some given either SP600125 or vehicle. LDH release assay flow cytometry used to measure apoptosis caused by The capases-3 measured Western blot. Our results showed...
No interventional study has been conducted in China to assess efficacy and safety of perampanel treating Chinese patients with epilepsy, nor there any on early add-on therapy China. This aimed as an treatment focal-onset seizures (FOS) or without focal-to-bilateral tonic-clonic (FBTCS) patients.In this multicenter, open-label, single-arm, phase 4 study, ≥ 12 years old FOS FBTCS who failed anti-seizure medication (ASM) monotherapy from 15 hospitals were enrolled treated (8-week titration...
Background: Parkinson’s disease is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. The dopamine precursor, levodopa, remains most effective and common treatment for this disorder. However, long-term administration levodopa known to induce characteristic dyskinesia, molecular mechanisms underlying dyskinesia are poorly understood. Methods: In study, we investigated effect 6-hydroxydopamine lesions chronic with on expression G protein-coupled...
Objective To study the expression of c-Jun N-terminal kinase (JNK) in hematoma peripheral region rat models after intracerebral hemorrhage (ICH) and explore effect thrombin inhibitor argathoban on JNK expression.Methods In first set,30 male SD rats weighed 250-300 g were randomized into sham-operated group (striatal injection saline 50 μL,n=6) ICH (intracerebral infusion autologous blood μL at corpus striatum,n=24); divided four subgroups (12 h,and 1,3 7 d ofautologous blood,n=6);Western...
Objective To analyze the clinical manifestations and MRI characteristics of hypertrophic olivary degeneration (HOD) to improve our knowledge for this disease reduce misdiagnosis.Methods Twelve patients with HOD,admitted hospital from 2009 2012,were chosen in study; their data,including onset age,protopathy other manifestations,and imaging SE sequence axial T1WI,T2WI FLAIR fast spin-echo imaging,were analyzed.Results The protopathy these 12 included pontine hemorrhage 5,cerebellar infarction...
Abstract Background We study the correlation between preoperative levodopa challenge test and efficacy of deep brain stimulation (DBS) surgery in Parkinson's disease (PD). Methods Fifty patients with PD who underwent DBS treatment our hospital from October 2016 to 2017 were enrolled this study. Using Unified Parkinson Disease Rating Scale-III (UPDRS-III) as an indicator, we analyzed improvement motor symptoms on by surgery. also discussed effects Results There was no results a linear muscle...
Objective To investigate the relationship between activation of RhoA and thrombin-induced neuron injury in cortex fetal rats. Methods The neurons from ratcortex were culturedin vitro for 8 d; then,they treated by thrombin at different concentrations (0,1,10,30 100 U/mL) 3 h,and 30 U/mL thrombm times (0,0.5,1,3 6 h);Western blotting was used to examine effects these treatments on RhoA.The pretreated with Exoenzyme C3,the inhibitor,for 0.5 incubated U/ml h; then,Western employed Rho A; besides...
Purinergic 2X7 receptor (P2X7R) and Nod like pyrin domain containing 3 (NLRP3) inflammasome contribute to the inflammatory activation. Great attention has been paid P2X7R NLRP3 in recent years, especially fields of central nervous system. To further elucidate role system, we review latest research progress composition physiological functions how they play their roles diseases system. Key words: Purinergic receptor; Nod inflammasome; Central system disease
Abstract Oxidative stress is implicated in functional recovery after brain damage caused by intracerebral hemorrhage (ICH). Histone deacetylase 6 (HDAC6) plays an important role initiation of oxidative stress. However, studies have not explored the and mechanism HDAC6 mediating ICH. Our study revealed knockout mice are resistant to ICH-induced resultant neuronal apoptosis, as analyses performed through MDA NADPH/NADP+ assays, ROS detection determination expression levels apoptosis-related...