A5047328481- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Hereditary Neurological Disorders
- Water Systems and Optimization
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Building Energy and Comfort Optimization
- Cellular transport and secretion
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Water-Energy-Food Nexus Studies
- Melanoma and MAPK Pathways
- Advanced Proteomics Techniques and Applications
- Computational Drug Discovery Methods
VIB-KU Leuven Center for Cancer Biology
2020-2024
KU Leuven
2022-2024
Waterlandziekenhuis
2022
Abstract Charcot–Marie–Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy caused by a 1.5 Mb tandem duplication of chromosome 17 harbouring PMP22 gene. This dose-dependent overexpression results in disrupted Schwann cell myelination nerves. To obtain better insights into underlying pathogenic mechanisms CMT1A, we investigated role cellular homeostasis CMT1A mouse models and patient-derived induced pluripotent stem cells differentiated precursors (iPSC-SCPs). We...
One of the key limitations targeted cancer therapies is rapid onset therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously identified lipogenic regulator SREBP-1 a central mediator resistance to MAPK-targeted therapy. Reasoning that lipogenesis-mediated alterations in membrane lipid poly-unsaturation lie at basis resistance, fatty acid synthase (FASN) player this pathway evoke an exquisite vulnerability clinical inducers reactive oxygen species (ROS), thereby...
Abstract Recent advances in spatial omics methods are revolutionising biomedical research by enabling detailed molecular analyses of cells and their interactions native state. As most technologies capture only a specific type molecules, there is an unmet need to enable integration multiple spatial-omics datasets. This, however, presents several challenges as these typically operate on separate tissue sections at disparate resolutions. Here, we established multi-omics pipeline co-registration...
Abstract Duplication of PMP22 causes Charcot-Marie-Tooth disease type 1A (CMT1A) and is known to disrupt the lipid metabolism in myelinating Schwann cells by unknown mechanisms. By using two CMT1A mouse models overexpressing human , we discovered that dose-dependently downregulates genes are involved cholesterol metabolism. Lipidomic analysis on sciatic nerves confirmed metabolic abnormalities primarily associated with sphingolipids. We observed similar lipidomic profiles downregulation...
Abstract Tumor growth is inevitably accompanied by changes in the tumor-microenvironment to which cancer cells have adapt order thrive. Alterations metabolism and blood perfusion of solid tumors been suggested drive a spontaneous increase tumoral temperature. However, it currently unknown if this phenomenon affects biology. We found increased temperature human pancreatic ductal adenocarcinoma (PDAC) tumors. By mimicking observation PDAC cell lines, we that altering cellular lipidome...