A5007834911- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Biochemical and Molecular Research
- Effects of Radiation Exposure
- S100 Proteins and Annexins
- Protein Kinase Regulation and GTPase Signaling
- Bioactive Compounds and Antitumor Agents
- Ion channel regulation and function
- Alzheimer's disease research and treatments
- Connexins and lens biology
- Autophagy in Disease and Therapy
- Plant-based Medicinal Research
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
Centre National de la Recherche Scientifique
2017-2022
Université de Tours
2019-2022
McGill University
2022
McGill University Health Centre
2022
Lebanese University
2021
Niche leucémique et métabolisme oxydatif
2019
Background: Colorectal cancer (CRC) is a highly devastating cancer. Ca2+-dependent channels are now considered key regulators of tumor progression. In this study, we aimed to investigate the association non-voltage gated Ca2+ and potassium (KCa) with CRC using transcriptional profile their genes. Methods: We selected total 35 genes covering KCa KCNN1–4, KCNMA1 subunits KCNMB1–4, endoplasmic reticulum (ER) calcium sensors STIM1 STIM2, ORAI1–3 family cation TRP (TRPC1–7, TRPA1, TRPV1/2,4–6...
Abstract The bone marrow (BM) niche impacts the progression of acute myeloid leukemia (AML) by favoring chemoresistance AML cells. Intimate interactions between leukemic cells and BM mesenchymal stromal (BM-MSCs) play key roles in this process. Direct intercellular communications hematopoietic BM-MSCs involve connexins, components gap junctions. We postulated that blocking junction assembly could modify cell–cell consequently chemoresistance. comparison from patients healthy donors revealed...
Loss of connexin-mediated cell-cell communication is a hallmark breast cancer progression. Pannexin1 (PANX1), glycoprotein that shares structural and functional features with connexins engages in cell its environment, highly expressed metastatic foci; however, PANX1 contribution to progression still obscure. Here we report elevated expression different (BRCA) subtypes using RNA-seq data from The Cancer Genome Atlas (TCGA). correlated poorer outcomes TCGA BRCA patients. In addition, gene set...
Abstract Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here crucial role of cyclin D1 in promoting this effect cyclin-dependent kinase (CDK)4/6-independent manner multiple myeloma (MM) cells. show that oncoprotein targets hexokinase 2 (HK2), major glycolysis regulator, through two original molecular mechanisms cytoplasmic and nuclear compartments. In cytoplasm, binds HK2 at outer membrane, nucleus, it...
Mesenchymal stem cells (MSC)-spheroid models favor maintenance of stemness, ex vivo expansion and transplantation efficacy. Spheroids may also be considered as useful surrogate the hematopoietic niche. However, accessibility to primary cells, from bone marrow (BM) or adipose tissues, limit their experimental use lack consistency in methods form spheroids affect data interpretation. In this study, we aimed create a simple model by examining ability cell lines, human (HS-27a HS-5) murine...
In acute myeloid leukemia (AML), a low level of reactive oxygen species (ROS) is associated with leukemic stem cell (LSC) quiescence, whereas high promotes blast proliferation. ROS homeostasis relies on tightly-regulated balance between the antioxidant and oxidant systems. Among oxidants, NADPH oxidases (NOX) generate as physiological function. Although it has been reported in AML initiation development, contribution NOX to production remains be clarified. The aim this study was investigate...
Abstract Acriflavine (ACF) is an antiseptic with anticancer properties, blocking the growth of solid and haematopoietic tumour cells. Moreover, this compound has been also shown to overcome resistance cancer cells chemotherapeutic agents. ACF target hypoxia‐inducible factors (HIFs) activity, which are key effectors hypoxia‐mediated chemoresistance. In study, we showed that inhibits survival chronic myeloid leukaemia (CML) acute (AML) cell lines in normoxic conditions. We further demonstrated...
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) involvement has been established in the oncogenic cell signaling of acute myeloid leukemia (AML) cells and crosstalk with their niche. We have shown an expression NOX subunits AML lines while activity is lacking absence exogenous stimulation. Here, we used as models to investigate specificity VAS3947, a current inhibitor. Results demonstrated that VAS3947 induces apoptosis independently its anti-NOX activity. High-performance...
Acute myeloid leukemia (AML) is characterized by the accumulation of undifferentiated blast cells in bone marrow and blood. In most cases AML, relapse frequently occurs due to resistance chemotherapy. Compelling research results indicate that drug cancer highly dependent on intracellular levels reactive oxygen species (ROS). Modulating ROS therefore a valuable strategy overcome chemotherapy leukemic cells. this study, we evaluated efficiency diphenyleneiodonium (DPI)-a well-known inhibitor...
Advances in large-scale proteomics analysis have been very useful understanding pathogenesis of diseases and elaborating therapeutic strategies. Proteomics has employed to study Parkinson disease (PD); however, sparse studies reported proteome investigation after cell therapy approaches. In this study, we used liquid chromatography–tandem mass spectrometry systems biology identify differentially expressed proteins a translational mouse model PD therapy. Proteins were extracted from five...
Acute myeloid leukaemia (AML) is characterized by the accumulation of undifferentiated blast cells in bone marrow and blood. In most AMLs, relapse frequently occurs due to resistance chemotherapy. Compelling research results indicate that drug cancer highly dependent on intracellular levels reactive oxygen species (ROS). Modulating ROS therefore a valuable strategy overcome chemotherapy leukemic cells. this study, we evaluated efficiency diphenyleneiodonium (DPI), well-known inhibitor...
Background: Bone marrow niche of acute myeloid leukemia (AML) regulates leukemic progression by favoring cell quiescence and chemoresistance. Niche components, especially mesenchymal stromal cells (MSCs) protect from chemotherapy‐induced apoptosis. Direct intercellular communications between hematopoietic stem MSCs involve connexins, key components gap junctions, which could be interresting targets to reverse this phenomenom. Aims: We postulated that blocking the assembly connexins modify...
Abstract Mesenchymal stem cells (MSCs)-derived spheroid models favor maintenance of stemness, ex vivo expansion and transplantation efficacy. Spheroids may also be considered as useful surrogate the hematopoietic niche. However, accessibility to primary cells, from bone marrow (BM) or adipose tissues, limit their experimental use lack consistency in methods form spheroids affect data interpretation. In this study, we aimed create a simple model by examining ability cell lines, human (HS-27a...