A5014525676- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Animal Behavior and Reproduction
- Animal Virus Infections Studies
- Parasitic Infections and Diagnostics
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Rabies epidemiology and control
- Mycobacterium research and diagnosis
- Bat Biology and Ecology Studies
- Alzheimer's disease research and treatments
- Immune Response and Inflammation
- Amoebic Infections and Treatments
- Immune Cell Function and Interaction
- Veterinary Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Genomics and Phylogenetic Studies
- Organ Transplantation Techniques and Outcomes
- Immune responses and vaccinations
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Poxvirus research and outbreaks
Australian Centre for Disease Preparedness
2021-2025
Commonwealth Scientific and Industrial Research Organisation
2021-2025
The University of Queensland
2018-2023
University of Peradeniya
2015-2018
Animal and Plant Health Agency
2016
University of Liverpool
2016
A novel lyssavirus was isolated from brains of Indian flying foxes (Pteropus medius) in Sri Lanka. Phylogenetic analysis complete virus genome sequences, and geographic location host species, provides strong evidence that this is a putative new designated as Gannoruwa bat lyssavirus.
Biting midges (Culicoides spp.) are important vectors of several insect borne arboviruses but underrepresented in terms availability high-resolution genomic resources. We assembled and annotated complete mitochondrial genomes for two Culicoides species, namely C. brevitarsis imicola which proven Bluetongue Virus (BTV). used both long read short sequencing technologies to assemble the circular genomes. The genome sizes 17,100 bp 17,031 bp, respectively, all comprising 37 genes, including 13...
Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body evidence that children are also less susceptible Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) infection with the ancestral viral isolate. However, emergence SARS-CoV-2 variants concern (VOCs) has been associated an increased number pediatric infections. Whether this result widespread adult vaccination or fundamental changes in biology remain be...
Abstract Background The Australian black swan ( Cygnus atratus ) is an iconic species with contrasting plumage to that of the closely related northern hemisphere white swans. relative geographic isolation may have resulted in a limited immune repertoire and increased susceptibility infectious diseases, notably diseases from which Australia has been largely shielded. Unlike mallard ducks mute olor ), extremely sensitive highly pathogenic avian influenza. Understanding this impaired by absence...
We describe emergence of Buruli ulcer in urban Geelong, Victoria, Australia, and examine timing proximity human cases to detection Mycobacterium ulcerans DNA possum feces. M. ulcerans-positive feces preceded by up 39 months, constituting an early warning impending risk for ulcer.
Buruli ulcer (BU) endemicity is changing in Victoria, Australia. This study describes the emergence of BU cases urban Geelong and examines timing proximity human to environmental Mycobacterium ulcerans DNA detection possum faeces. From 2011-2022, 80 were reported, with clusters emerging new endemic areas from 2019 onwards. Temporal analysis revealed occurred near M. positive faeces, that preceded by up 39 months. Median diagnosis delay these was 7 weeks, longer than established areas. The...
Abstract Children typically experience more mild symptoms of COVID-19 when compared to adults. There is a strong body evidence that children are also less susceptible SARS-CoV-2 infection with the ancestral viral isolate. However, emergence variants concern (VOCs) has been associated an increased number pediatric infections. Whether this result widespread adult vaccination or fundamental changes in biology remains be determined. Here, we use primary nasal epithelial cells from and adults,...
Highly pathogenic avian influenza viruses (HPAIVs) in gallinaceous poultry are associated with viral infection of the endothelium, induction a 'cytokine storm, and severe disease. In contrast, Pekin ducks, HPAIVs rarely endothelial tropic, cytokine storm is not observed. To date, understanding these species-dependent differences pathogenesis has been hampered by absence pure culture duck chicken cells. Here, we use our recently established vitro cultures aortic cells to investigate response...
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests influenza are more prevalent in pregnant and/or obese individuals due to their impaired interferon response. We have recently shown the non-allergic, paucigranulocytic subtype of asthma is associated with type I production. Here, we seek address if this an increased emergence variants. Compared controls, mice had disease severity and Specifically, PB1 mutations...
Toxocara pteropodis, an intestinal nematode, occurs in several captive and free-ranging pteropid bat species. We report infection Indian flying foxes (Pteropus medius) Sri Lanka contribute to our understanding of parasites P. medius.
Calodium hepaticum infection is rarely reported in carnivores. We describe two cases of C. infection, causing liver lesions, wild jungle cats ( Felis chaus ) Sri Lanka.
A 25 year old female captive Asian elephant weighing approximately 3000kgs died and was subjected to a complete necropsy within 5 hours post mortem. Grossly, the had sub-cutaneous edema, cecocolic intussusception ascites. Histopathological examination revealed multifocal, granulomatous, portal phlebitis in liver, peri-portal hepatitis with marked perisinusoidal fibrosis, multifocal granulomatous colitis intralesional Schistosoma eggs. To our knowledge, this is first report of an associated...
ABSTRACT The Australian black swan ( Cygnus atratus ) is an iconic species with contrasting plumage to that of the closely related Northern Hemisphere white swans. relative geographic isolation may have resulted in a limited immune repertoire and increased susceptibility infectious disease, notably diseases from which Australia has been largely shielded. Indeed, unlike Mallard ducks mute olor ), extremely sensitive severe highly pathogenic avian influenza (HPAI). Understanding this impaired...
The ISOSeq data was created using PacBio Sequel II. RNA extracted from three mute swans for the purpose of swan genome annotation.
Senile plaques and cerebral amyloid angiopathy (CAA)?are well-documented in various mammals, several species even exhibit neurofibrillary tangle (NFT). However, we know far less about whether such symptoms are present birds. Therefore, here clarified the occurrence pathogenesis of avian aβ-related lesions, analyzing aβ amino-acid sequence across 28 birds at multiple life stages, representing 15 species, 14 genera, 9 nine families.?We also determined expected after comparing data from brains...