A5076586714- Viral Infections and Vectors
- Virology and Viral Diseases
- Rabies epidemiology and control
- Innovations in Medical Education
- Mycobacterium research and diagnosis
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Bat Biology and Ecology Studies
- Tuberculosis Research and Epidemiology
- Digital Storytelling and Education
- Teacher Education and Leadership Studies
- Interprofessional Education and Collaboration
- Infectious Diseases and Mycology
- Vector-Borne Animal Diseases
- Reflective Practices in Education
- Education Systems and Policy
- Clinical Reasoning and Diagnostic Skills
- Literacy, Media, and Education
- Influenza Virus Research Studies
- Collaborative Teaching and Inclusion
- Respiratory viral infections research
- Gut microbiota and health
- Higher Education Learning Practices
- Wildlife Ecology and Conservation
- Nursing education and management
Commonwealth Scientific and Industrial Research Organisation
2010-2024
CSIRO Health and Biosecurity
2017-2024
Health Sciences and Nutrition
2024
University Health Network
2020-2023
University of Toronto
2017-2023
The Wilson Centre
2019-2023
Australian Centre for Disease Preparedness
2013-2022
Glasgow Caledonian University
2012-2020
Sunnybrook Health Science Centre
2019
Health Sciences Centre
2019
Bats harbor many emerging and reemerging viruses, several of which are highly pathogenic in other mammals but cause no clinical signs disease bats. To determine the role interferons (IFNs) ability bats to coexist with we sequenced type I IFN locus Australian black flying fox, Pteropus alecto, providing what is, our knowledge, first gene map region any bat species. Our results reveal a contracted family consisting only 10 IFNs, including three functional IFN-α loci. Furthermore, genes...
Background Over the last two decades, competency-based frameworks have been internationally adopted as primary educational approach in medicine. Yet medical education (CBME) remains contested academic literature. We look broadly at nature of this debate to explore how it may shape scholars' understanding CBME, and its implications for research practice. In doing so, we deconstruct unarticulated discourses assumptions embedded CBME Methods assembled an archive literature focused on CBME. The...
Within host-parasite communities, viral co-circulation and co-infections of hosts are the norm, yet studies significant emerging zoonoses tend to focus on a single parasite species within host. Using multiplexed paramyxovirus bead-based PCR urine samples from Australian flying foxes, we show that multi-viral shedding fox populations is common. We detected up nine bat paramyxoviruses shed synchronously. Multi-viral infrequently coalesced into an extreme, brief spatially restricted pulse,...
Abstract Vaccines against SARS-CoV-2 are likely to be critical in the management of ongoing pandemic. A number candidates Phase III human clinical trials, including ChAdOx1 nCoV-19 (AZD1222), a replication-deficient chimpanzee adenovirus-vectored vaccine candidate. In preclinical efficacy challenge was evaluated ferret model infection. Groups ferrets received either prime-only or prime-boost administration via intramuscular intranasal route. All combinations resulted significant reductions...
Buruli ulcer (BU) is a neglected tropical disease caused by infection of subcutaneous tissue with Mycobacterium ulcerans. BU commonly reported across rural regions Central and West Africa but has been increasing dramatically in temperate southeast Australia around the major metropolitan city Melbourne, most transmission occurring summer months. Previous research shown that Australian native possums are reservoirs M. ulcerans they shed bacteria their fecal material (excreta). Field surveys...
Abstract In this article we introduce a synthesis of education “paradigms,” adapted from multi-disciplinary body literature and tailored to health professions (HPE). Each paradigm involves particular perspective on the purpose education, nature knowledge, what knowledge is valued included in curriculum, it means learn how learning assessed, roles teachers learners process. We aim foster awareness these different paradigms look practice illustrate importance alignment between teaching,...
Bats are an important host of various viruses which deadly to humans and other mammals but do not cause outward signs illness in bats. Furthering our understanding the unique features immune system bats will shed light on how they tolerate viral infections, potentially informing novel antiviral strategies animals.
Abstract Context Critical reflection may improve health professionals’ performance of the social roles care (eg collaboration) in indeterminate zones practice that are ambiguous, unique, unstable or value‐conflicted. Research must explore critical and how it is developed. In this study, we explored what consisted a context known for indeterminacy, to sources participants attributed their critically reflective insights approaches. Methods The study was interface between education children...
In recent years reported cases of Buruli ulcer, caused by Mycobacterium ulcerans , have increased substantially in Victoria, Australia, with the epidemic also expanding geographically. To develop an understanding how M . circulates environment and transmits to humans we analyzed environmental samples collected from 115 properties ulcer postcode-matched control properties, for presence Environmental factors associated odds at a property included certain native plant species vegetation...
Old World frugivorous bats have been identified as natural hosts for emerging zoonotic viruses of significant public health concern, including henipaviruses (Nipah and Hendra virus), Ebola virus, Marburg virus. Epidemiological studies these in often utilize serology to describe viral dynamics, with particular attention paid juveniles, whose birth increases the overall susceptibility population a outbreak once maternal immunity wanes. However, little is understood about bat immunology,...
Bats are the natural reservoir host for a number of zoonotic viruses, including Hendra virus (HeV) which causes severe clinical disease in humans and other susceptible hosts. Our understanding ability bats to avoid following infection with viruses such as HeV has come predominantly from vitro studies focusing on innate immunity. Information early response vivo is lacking there no comparative data responses compared animals that succumb disease. In this study, we examined sites replication...
Bats are known reservoirs of a wide variety viruses that rarely result in overt clinical disease the bat host. However, anthropogenic influences on landscape and climate can change species assemblages interactions, as well undermine host-resilience. The cumulative is disturbance bat–pathogen dynamics, which facilitate spillover events to sympatric species, may threaten communities already facing synergistic stressors through ecological change. Therefore, characterisation viral pathogens...
Critical reflection supports enactment of the social roles care, like collaboration and advocacy. We require evidence that links critical teaching approaches to future critically reflective practice. thus asked: does a theory-informed approach influence what learners talk about (i.e. topics discussion) how they whether in ways) during subsequent learning experiences? Pre-clinical students (n = 75) were randomized into control intervention conditions (8 groups each, up 5 interprofessional...
Adaptive expertise (AE) and reflective practice (RP), two influential resonant theories of professional in their own right, may further benefit health professions education if carefully combined. The current societal systemic context is primed for both AE RP. Both bodies work position practitioners as agentive, learning continually thoughtfully throughout careers, particularly order to manage unprecedented situations well. Similar on the surface, roots practices RP diverge at key junctures...
We describe emergence of Buruli ulcer in urban Geelong, Victoria, Australia, and examine timing proximity human cases to detection Mycobacterium ulcerans DNA possum feces. M. ulcerans-positive feces preceded by up 39 months, constituting an early warning impending risk for ulcer.
Habitat-mediated global change is driving shifts in species' distributions which can alter the spatial risks associated with emerging zoonotic pathogens. Many infectious pathogens are transmitted by highly mobile species, including bats, act as spill-over hosts for pathogenic viruses. Over three years, we investigated seroepidemiology of paramyxoviruses and Australian bat lyssavirus a range-expanding fruit bat, Grey-headed flying fox (Pteropus poliocephalus), new camp Adelaide, South...
Abstract Background The emergence of high pathogenicity strains Influenza A virus in a variety human and animal hosts, with wide geographic distribution, has highlighted the importance rapid identification subtyping for outbreak management treatment. Type can be classified into subtypes according to viral envelope glycoproteins, hemagglutinin neuraminidase. Here we review existing specificity amplification published primers subtype neuraminidase genes describe new broad spectrum primer pair...
Hendra virus (HeV) is an important emergent in Australia known to infect horses and humans certain regions of the east coast. Whilst pteropid bats ("flying foxes") are considered natural reservoir HeV, which four mainland species principal has been a source ongoing debate, particularly as shared roosting common. To help resolve this, we sampled colony consisting just one these species, grey-headed flying fox, (Pteropus poliocephalus), at southernmost extent its range. Using pooled urine...
The respiratory Influenza A Viruses (IAVs) and emerging zoonotic viruses such as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pose a significant threat to human health. To accelerate our understanding of the host–pathogen response viruses, use more complex in vitro systems normal bronchial epithelial (NHBE) cell culture models has gained prominence an alternative animal models. NHBE cells were differentiated under air-liquid interface (ALI) conditions form pseudostratified...
Purpose While research is beginning to reveal the potential of dialogue in sparking critical reflection (critically reflective ways seeing), additional needed guide teaching toward enabling critically practice seeing and doing). An experimental study was conducted investigate impact dialogic learning on practice, compared discussion-based learning. The intervention integrated theory Mikhail Bakhtin with disability studies. Method In interprofessional groups 4, medical, occupational therapy,...