A5082949630- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Rabies epidemiology and control
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Vector-Borne Animal Diseases
- Animal Genetics and Reproduction
- Malaria Research and Control
- Plant Molecular Biology Research
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Genetic and phenotypic traits in livestock
- SARS-CoV-2 detection and testing
- Sugarcane Cultivation and Processing
- Scientific Research Methodologies and Applications
- Plant Gene Expression Analysis
- BRCA gene mutations in cancer
- RNA and protein synthesis mechanisms
- Advances in Oncology and Radiotherapy
- COVID-19 epidemiological studies
Australian Centre for Disease Preparedness
2013-2022
Commonwealth Scientific and Industrial Research Organisation
2013-2022
CSIRO Health and Biosecurity
2018
Animal, Food and Health Sciences
2013-2014
Hendrix College
2011-2013
Conway School of Landscape Design
2011-2012
Imperial College London
2006
QIMR Berghofer Medical Research Institute
1984
St Mary's Hospital
1955
Abstract Vaccines against SARS-CoV-2 are likely to be critical in the management of ongoing pandemic. A number candidates Phase III human clinical trials, including ChAdOx1 nCoV-19 (AZD1222), a replication-deficient chimpanzee adenovirus-vectored vaccine candidate. In preclinical efficacy challenge was evaluated ferret model infection. Groups ferrets received either prime-only or prime-boost administration via intramuscular intranasal route. All combinations resulted significant reductions...
The zoonotic potential of paramyxoviruses is particularly demonstrated by their broad host range like the highly pathogenic Hendra and Nipah viruses originating from bats. But while so far all bat-borne have been identified in fruit bats across Africa, Australia, South America, Asia, we describe detection characterization first free-ranging European Moreover, examined possible impact paramyxovirus infection on individual animals comparing histo-pathological findings virological results....
The pigeon crop is specially adapted to produce milk that fed newly hatched young. process of production begins when the germinal cell layer rapidly proliferates in response prolactin, which results a mass epithelial cells are sloughed from and regurgitated We proposed evolution built upon ability avian keratinocytes accumulate intracellular neutral lipids during cornification epidermis. However, this has not been characterised.We identified epidermal differentiation complex draft genome...
Cases of vomiting and diarrhoea were reported in racing pigeons Western Australia May, 2016. Morbidity mortality rates high. Similar clinical disease was seen Victoria December by early 2017 had been all states except the Northern Territory, different classes domestic pigeon–racing, fancy meat bird–and a flock feral pigeons. Autopsy findings frequently unremarkable; histological examination demonstrated significant hepatic necrosis as major consistent lesion, often with minimal inflammatory...
Understanding Zika virus infection dynamics is essential, as its recent emergence revealed possible devastating neuropathologies in humans, thus causing a major threat to public health worldwide. Recent research allowed breakthrough our understanding of the and host pathogenesis; however, little known on impact main vector, Aedes aegypti. Here we show how targets aegypti's neurons induces changes behavior. Results are compared dengue virus, another flavivirus, which triggers different...
Ducks are important maintenance hosts for avian influenza, including H5N1 highly pathogenic influenza viruses. A previous study indicated that persistence of viruses in ducks after the development humoral immunity may drive viral evolution following immune selection. As HPAI is endemic Indonesia, this mechanism be understanding region. To determine capability domestic to maintain prolonged shedding Indonesian clade 2.1 virus, two groups Pekin were inoculated through eyes, nostrils and...
In eukaryotic cells, the highly conserved FACT (FAcilitates Chromatin Transcription) complex plays important roles in several chromatin-based processes including transcription initiation and elongation. During elongation, interacts directly with nucleosomes to facilitate histone removal upon RNA polymerase II (Pol II) passage assists reconstitution of following Pol passage. Although contribution process elongation has been well established, mechanisms that govern interactions between...
Low pathogenicity avian influenza viruses (LPAIVs) are generally asymptomatic in their natural hosts. LPAIVs can evolve into highly pathogenic forms, which affect and human populations with devastating consequences. The switch to virus (HPAIV) from LPAIV precursors requires the acquisition of multiple basic amino acids haemagglutinin cleavage site (HACS) motif. Through reverse genetics an H5N1 HPAIV, experimental infection chickens, we determined that containing five or more HACS motif were...
This study is the first report of experimental infection and transmission Menangle virus (MenPV) in pigs. Isolated 1997 from piglets that were stillborn at a large commercial piggery New South Wales, Australia, MenPV recently identified paramyxovirus bat origin causes severe reproductive disease pigs an influenza-like illness, with rash, humans. Although successfully eradicated infected piggery, was only isolated affected fetuses during period disease, thus mode between not established. To...
The highly conserved FACT (FAcilitates Chromatin Transactions) histone chaperone assists in the transcription elongation process first by facilitating removal of histones front transcribing RNA polymerase II (Pol II) and then contributing to nucleosome reassembly wake Pol passage. Whereas it is well established that localizes across actively transcribed genes, mechanisms regulate recruitment disengagement from chromatin during still remain be elucidated. Using Saccharomyces cerevisiae model...
Abstract Background Bats are a major reservoir of emerging infectious viruses. Many these viruses highly pathogenic to humans however bats remain asymptomatic. The mechanism by which control viral replication is unknown. Here we utilize an integrated approach proteomics informed transcriptomics compare the response immortalized bat and human cells following infection with bat-borne Hendra virus (HeV). Results host between cell lines was significantly different at both mRNA protein levels....
H5N1 highly pathogenic avian influenza (HPAI) virus causes high mortality of infected birds, with infection in multiple organs, including feathers. Feathers have been proposed as samples for diagnosis HPAI and this study is part a broader investigation validating the use feathers diagnostic purposes. To understand characterize morphological basis feather infection, sections from 7 different skin tracts ducks chickens 3 clades Indonesia Vietnam were examined histologically. Results showed...
Avian influenza viruses of H5 subtype can cause highly pathogenic disease in poultry. In March 2014, a new reassortant H5N6 avian virus emerged Lao People's Democratic Republic. We have assessed the pathogenicity, pathobiology and immunological responses associated with this chickens. Infection caused moderate to advanced 6 chickens within 48 h mucosal inoculation. High titers were observed blood tissues (kidney, spleen, liver, duodenum, heart, brain lung) taken at euthanasia. Viral antigen...
"Characterization of Ross River Viruses Isolated from Patients with Polyarthritis in New Caledonia and Wallis Futuna Islands" published on Nov 1984 by The American Society Tropical Medicine Hygiene.
Although avian H5N1 influenza virus has yet to develop the capacity for human-to-human spread, severity of rare cases human infection warranted intensive follow-up potentially exposed individuals that may require antiviral prophylaxis. For countries where drugs are limited, World Health Organization (WHO) developed a risk categorization different levels exposure environmental, poultry, or sources infection. While these take into account source, they do not likely mode entry individual have...
West Nile virus (WNV; family Flaviviridae ; genus Flavivirus ) group members are an important cause of viral meningoencephalitis in some areas the world. They exhibit marked variation pathogenicity, with lineages (such as those from North America) causing high prevalence severe neurological disease, whilst others Australian Kunjin virus) rarely disease. The aim this study was to characterize WNV disease a mouse model and elucidate pathogenetic features that distinguish variation. Tenfold...
Abstract Bats are implicated as the natural reservoirs for several highly pathogenic viruses that can infect other animal species, including man. Here, we investigate potential two recently discovered bat rubulaviruses, Achimota virus 1 (AchPV1) and 2 (AchPV2), isolated from urine collected under urban ( Eidolon helvum ) roosts in Ghana, West Africa, to small laboratory animals. AchPV1 AchPV2 classified family Paramyxoviridae cluster with derived zoonotic rubulaviruses (i.e. Sosuga, Menangle...
Newcastle disease is an important of poultry caused by virulent strains virus (NDV). During the 1998 to 2002 outbreaks in Australia, it was observed that mild clinical signs seen some chickens infected with NDV did not correlate viruses’ fusion protein cleavage site motifs or standard pathogenicity indices. The 2 Australian isolates evaluated experimentally challenged based on evaluation, histopathology, immunohistochemistry, and molecular techniques. One these isolates, Meredith/02, shown...
Chikungunya virus (CHIKV) is transmitted by Aedes mosquitoes and causes prolonged arthralgia in patients. After crossing the mosquito midgut barrier, disseminates to tissues including head salivary glands. To better understand interaction between albopictus CHIKV, we performed RNASeq analysis on pools of heads parts thorax 8 days post infection, which identified 159 differentially expressed transcripts infected mosquitos compared uninfected controls. validation using RT-qPCR (reverse...
The nucleolus is a common target of viruses and viral proteins, but for many the functional outcomes significance this targeting remains unresolved. Recently, first intranucleolar function protein cytoplasmically-replicating negative-sense RNA virus (NSV) was identified, with finding that matrix (M) Hendra (HeV) (genus Henipavirus, family Paramyxoviridae) interacts Treacle within nucleolar subcompartments mimics cellular mechanism DNA-damage response (DDR) to suppress ribosomal (rRNA)...