A5074158549- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Pharmaceutical and Antibiotic Environmental Impacts
- Nosocomial Infections in ICU
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Neonatal and Maternal Infections
- Cystic Fibrosis Research Advances
- Ottoman and Turkish Studies
- Respiratory viral infections research
- Fungal Infections and Studies
- Plant Pathogenic Bacteria Studies
- Nephrotoxicity and Medicinal Plants
- Infections and bacterial resistance
- Oral microbiology and periodontitis research
- Bacteriophages and microbial interactions
- Animal Behavior and Welfare Studies
- Blood Coagulation and Thrombosis Mechanisms
- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
Marmara University
2013-2021
Marmara Üniversitesi Eğitim ve Araştırma Hastanesi
2021
Maltepe University
2019
Objective: Carbapenemase-producing Klebsiella pneumoniae (CPKp) infections are increasing worldwide. We investigated the in vitro synergistic activity of fosfomycin (FOS) with meropenem (MRP), amikacin (AMK) and colistin (COL) against OXA-48 and/or New Delhi metallo-beta-lactamase (NDM)-producing Kp blood isolates. Materials Methods: Seventeen CPKp isolates were studied. The broth microdilution method was used for COL, MRP AMK susceptibilities, while agar dilution FOS. Synergy tested by...
In this study, the performance of "RESIST-3 O.K.N. K-SeT" (Coris BioConcept, Gembloux, Belgium) immunochromatographic assay was evaluated in 132 Klebsiella pneumoniae comprising 102 carbapenem resistant and 30 susceptible isolates. Genotypically known isolates Gram negative bacteria (n=22) including various species were also tested by as controls. The run PCR for blaKPC, blaIMP, blaVIM, blaNDM, blaOXA-48. rates blaOXA-48, blaKPC found at 52.9%, 39.2%, 2.0%, respectively. Both blaNDM...
Colistin resistant Acinetobacter baumannii strains are of great concern worldwide. However, the role efflux pumps in colistin resistance needs to be elucidated. We investigated changes MICs 29 A. isolates response resistance-nodulation-division (RND)-type pump inhibitor (EPI) and alterations AdeR AdeS two-component regulatory proteins previously associated with overproduction AdeAB. The EPI, 1-(1-naphthylmethyl)-piperazine (NMP), led significant reductions MICs. At least one following amino...
Abstract Background We report a nosocomial outbreak caused by Burkholderia cepacia that occurred among six patients admitted in the medical and surgical intensive care unit between 04 March 2019 02 April Istanbul, Turkey. Methods The investigation was launched on 11 five days after detection of B. four different patients. defined potential reservoirs started environmental screening. sampled liquid solutions used patient activities. Pulse-field gel electrophoresis (PFGE) performed to...
The aim of this study was to evaluate the prevalence nasopharyngeal (NP) carriage and serotype distribution antimicrobial resistance Streptococcus pneumoniae in children with chronic diseases, which predisposes them invasive pneumococcal disease comparison that healthy children. A cross-sectional performed between February 2015 2016 Istanbul, Turkey. We enrolled 1,024 diseases 394 aged 0-18 years. overall S. NP (SPNP) 9.8%, 8.4% 10.3% diseases. rates SPNP were 17.5%, 13.5%, 10.5%, 9.3%,...
Antimicrobial resistance (AMR) is one of the most important problems threatening human health worldwide. The impact Coronavirus disease-2019 (COVID-19) pandemic on AMR continues to be discussed. Some researchers argue that will increase rates, while others suggest opposite. aim this study was investigate change in Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus strains three cross-sectional periods Türkiye, first before COVID-19 pandemic, second third during pandemic....
Background: Mucormycosis is a rare, worldwide fungal infection with high mortality, which mostly affects immunocompromised patients. Compared to large parts of Asia, Europe, and the USA, information on clinical expression species distribution in mucormycosis Turkey limited. Objectives methods: The main aim this study was evaluate demographic features cases, identify isolates at level by using matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF), compare...
Abstract Urinary tract infections are one of the most common bacterial and rapid diagnosis infection is essential for appropriate antibiotic therapy. The goal our study was to identify urinary pathogens directly by MALDI-TOF MS perform susceptibility tests in order shorten period spent culturing. Urine samples submitted culture Clinical Microbiology Laboratory were enrolled this study. screened leukocyte bacteria amount flow cytometry. Samples with load 10 6 –10 7 /mL tested (AST) performed....
The aim of the present study was to determine diagnostic value soluble urokinase plasminogen activator receptor (suPAR) in pediatric patients with febrile neutropenia. A prospective case-control performed. Patients included 29 children neutropenia (FN) and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on day admission 4th 7th days hospital stay. median (minimum–maximum) serum levels suPAR first 2.08 (0.93–9.42) 2.22 (1.08–5.13) ng/mL...
The carbapenem-resistant Bacteroides fragilis group (CR-BFG) bacteria have been reported in several countries recently with increasing global attention. high incidence of CR-BFG isolated from our hospitalized patients has become an important problem. Therefore, we aimed to determine the frequency and associated factors for intestinal colonization by carbapenem-non-susceptible BFG (CNS-BFG) among adult at intensive care units, neurosurgery internal medicine wards hospital.Rectal swabs (n =...
Due to the limited number of antimicrobials be used in treatment infections caused by Gram-negative microorganisms with multi-drug resistance recently, old antibiotics such as colistin have started preferred frequently. However, some problems are encountered antibiotic susceptibility tests (disk diffusion, gradient test, automated systems) which frequently routine laboratory due cationic nature colistin. For this reason, only broth microdilution test is recommended European Committee on...
This study aimed to investigate serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates obtained from children with chronic respiratory diseases admitted hospital a diagnosis acute exacerbations between 2008-2010 at Marmara University Hospital, Istanbul, Turkey. Sixty one S.pneumoniae strains isolated the samples patients were studied for erythromycin, clindamycin, tetracyline, trimethoprim-sulphametoxazole (TMP-SMX), vancomycin, levofloxacin susceptibilities...
<strong>Objectives</strong>: The use of carbapenems for treating infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae has increased. Consequently, this practice resulted in the emergence carbapenem resistance. In study, we aimed to determine mutant prevention concentrations (MPCs) and development resistance ESBL-producing bacteria. <br> <strong>Material Method</strong>: test group included isolates Escherichia coli Klebsiella pneumonia that produced...
Objective: The aim of the study was to investigate presence extended -spectrum beta-lactamases (ESBL) TEM, SHV, and CTX-M which are frequently observed all over world, rare IBC-1 beta-lactamase enzyme. Material Method: Thirty strains that isolated from various clinical samples inpatient at Marmara University Hospital, were phenotypically positive for ESBL, IBC-1were included in study. Antimicrobial susceptibility tests performed both by disk diffusion agar dilution tests. E-test double-disc...
ÖZKarbapenem dirençli Enterobacteriaceae üyelerinin neden olduğu enfeksiyonların sıklığı tüm dünyada giderek artmakta olup mortalite oranları oldukça yüksektir.Bu kökenler ile oluşan ve kolonize hastaların hızlı tespiti, enfeksiyon kontrol protokollerinin uygulanması açısından önemlidir.Çalışmamızda erişkin yoğun bakım ünitelerinde yatan hastalarda karbapenem Klebsiella pneumoniae kökenleri gelişen kolonizasyon/enfeksiyon karbapenemaz tiplerinin araştırılması amaçlanmıştır.Bu çalışmaya hastalardan
Objectives: The incidence of infections caused by carbapenem-resistant Enterobacteriaceae has increased worldwide. Limitations in the development new antimicrobial agents have led clinicians to reconsider clinical efficiency old antibiotics, such as intravenous formulation fosfomycin, treatment multidrug-resistant Gram-negative bacterial infections. We investigated fosfomycin susceptibility carbapenemase-producing Klebsiella pneumoniae strains isolated prior use Turkey. Materials and...