A5022968852- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Cystic Fibrosis Research Advances
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Infective Endocarditis Diagnosis and Management
- Urinary Tract Infections Management
- Enterobacteriaceae and Cronobacter Research
- Actinomycetales infections and treatment
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Nosocomial Infections in ICU
- Diphtheria, Corynebacterium, and Tetanus
- Brucella: diagnosis, epidemiology, treatment
- Listeria monocytogenes in Food Safety
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Salmonella and Campylobacter epidemiology
- Neutropenia and Cancer Infections
Hacettepe University
2013-2024
European Society of Clinical Microbiology and Infectious Diseases
2024
Karolinska Institutet
2022
Hacettepe University Hospital
2020
Ankara Numune Eğitim ve Araştırma Hastanesi
2012-2018
Creative Commons
2018
Ankara University
2018
Kırıkkale University
2018
Ankara Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi
2016
Abstract Objectives When bloodstream infections are caused by resistant bacteria, rapid antimicrobial susceptibility testing (RAST) is important for adjustment of therapy. The EUCAST RAST method, directly from positive blood cultures, was validated in a multi-laboratory study Europe. Methods performed 40 laboratories northern Europe (NE) and 15 southern (SE) clinical cultures Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus or Streptococcus pneumoniae....
Treatment of disseminated Trichosporon infections still remains difficult. Amphotericin B frequently displays inadequate fungicidal activity and echinocandins have no meaningful antifungal effect against this genus. Triazoles are currently the drugs choice for treatment infections. This study evaluates inhibitory activities five triazoles 90 clinical isolates asahii. MICs (μg/ml) were determined according to Clinical Laboratory Standards Institute microdilution method M27-A3 at 24 48 h using...
COVID-19-associated pulmonary aspergillosis (CAPA) has been reported as an important cause of mortality in critically ill patients with incidence rate ranging from 5% to 35% during the first and second pandemic waves.We aimed evaluate incidence, risk factors for CAPA by a screening protocol outcome third wave pandemic.This prospective cohort study was conducted two intensive care units (ICU) designated COVID-19 tertiary university hospital between 18 November 2020 24 April 2021. SARS-CoV-2...
Oral diseases and associated microbes are a risk factor for systemic can change the courses of these diseases. To date, epidemiological data on microbial oral infections scarce, longitudinal reports lacking.
Background: Community-acquired infection caused by extended-spectrum beta-lactamase (ESBL)-producing microorganisms has an increasing frequency. Aim: The aim of this study was to determine the fecal carriage ESBL and AmpC beta-lactamase-producing Enterobacteriaceae in community investigate cefotaxime-M (CTX-M) genes among isolates. Materials Methods: A total 1402 specimens which were collected from outpatients included study. screening, production, detection performed. Matrix-assisted laser...
Background Cefiderocol is generally active against carbapenem-resistant Klebsiella spp. (CRK) with higher MICs metallo-beta-lactamase producers. There a variation in cefiderocol interpretive criteria determined by EUCAST and CLSI. Our objective was to test CRK isolates compare susceptibilities using CLSI criteria.Methods A unique collection (n = 254) of mainly OXA-48-like- or NDM-producing bloodstream were tested disc diffusion (Mast Diagnostics, UK). Beta-lactam resistance genes multilocus...
The rise of antibiotic-resistant organisms necessitates the implementation rapid identification (ID) and antibiotic susceptibility testing (AST) methods for patient management. We aimed to analyze how ID AST reporting influenced clinicians' treatment decisions.
This study aimed to assess the performance of MALDI-TOF MS short incubation method for bacterial identification at short-term times improve reporting blood cultures. analysis was conducted intervals 2, 4, and 6 hours during development microbial biomass on solid media until successful achieved, with a final assessment 24 conventional identification. Species-level rates 2nd, 4th, 6th, 24th were 57.5%, 83.6%, 93.1%, 93.1% Gram-negative bacilli; 12.5%, 42.7%, 76.1%, 97.8% Gram-positive cocci...
Abstract Carbapenemase-producing and colistin resistant Klebsiella pneumoniae has become a worldwide healthcare problem. This study describes molecular characterization of carbapenemase-producing clinical K. isolates. A total 93 non-replicate carbapenem were recovered from specimens in university hospital during 2017–2019. Detection bla OXA-48 , KPC NDM-1 IMP VIM-1 mcr-1 -2, -3 -4, -5 -6, -7, -8 genes was performed by PCR. The bacterial isolates assigned to clonal lineages pulsed-field gel...
We investigated the change in epidemiology of nosocomial bloodstream infections (BSIs) caused by multidrug-resistant bacteria during Coronavirus Disease (COVID-19) and antibiotic consumption rates at a pandemic hospital Oncology Hospital which operated as COVID-19-free on same university campus. Significant increases infection density rate (IDRs) BSIs carbapenem-resistant Acinetobacter baumannii (CRAB) ampicillin-resistant Enterococcus faecium (ARE) were detected hospital, whereas Klebsiella...
Background: Carbapenem-resistant Pseudomonas aeruginosa is an endemic problem in several countries, notably Turkey. Objectives: This study aimed to investigate the underlying mechanisms contributing carbapenem resistance phenotype and enhance in-vitro activity of ceftolozane-tazobactam (C/T) ceftazidime-avibactam (C/A) against carbapenem-resistant P. strains. Methods: A total 114 strains were isolated from different types clinical specimens. The tested antibiotics evaluated using antibiotic...
Abstract MALDI-TOF MS provides fast, easy to perform and cost-effective diagnosis in clinical microbiology laboratories, however some cases results of should be confirmed with additional tests. This confirmation is especially important for causes life-threatening infections like Neisseria meningitidis . In our laboratory, three isolates were identified as N. by Bruker MALDI Biotyper (BD, USA) between April 2018 March 2019 from specimens blood, sputum, urine. 16S rRNA sequencing was performed...
Objectives: The limitations of treatment options in bloodstream infections caused by multidrug-resistant Acinetobacter baumannii (MDRAB) have been related to high morbidity and mortality. aim our present study was determine antimicrobial susceptibility profiles, molecular resistance patterns, biofilm properties A. isolated from infections. Materials Methods: In the study, a total 44 isolates were included. Antimicrobial profiles formation ability assessed. distribution class D...
Fakültesi Merkez Laboratuvarı'nda çeşitli klinik örneklerden izole edilmiş ve karbapenem direnci belirlenmiş 81 K. pneumoniae izolatında kolistine duyarlılık sıvı mikrodilüsyon yöntemiyle EUCAST standartlarına göre belirlenmiştir
To develop a scoring system to predict resistance ceftolozane/tazobactam in Pseudomonas aeruginosa strains isolated from respiratory specimens. A case-control study was conducted evaluate the risk factors associated with ceftolozane/tazobactam. Patients P. were defined as cases if they had ceftolozane/tazobactam-resistant strains, whereas those ceftolozane/tazobactam-susceptible test-negative controls. predictive based on binary logistic regression coefficients formulated The score's...
Accurate and rapid identification of yeast isolates have become important in recent years for not only antifungal susceptibility testing due to the species-specific clinical resistance breakpoints but also early initiation appropriate therapy. In microbiology laboratories species yeasts is often performed with several commercial systems based on biochemical properties rarely according physiological morphological characteristics. The aim this study was compare two common systems, VITEK 2 YST...
Objective: Here, we compared the impact of different polices on epidemiology Vancomycin-resistant Enterococcus faecium bloodstream infections (VRE-BSIs) in a tertiary care hospital including two buildings (oncology and adult hospitals) same campus. Material Methods: All patients who were hospitalized high-risk units screened weekly for VRE colonization via rectal swab between January 2006 2013. After 2013, screening was only performed cases suspicion outbreak during point prevalence studies...
Antimicrobial resistance (AMR) is one of the most important problems threatening human health worldwide. The impact Coronavirus disease-2019 (COVID-19) pandemic on AMR continues to be discussed. Some researchers argue that will increase rates, while others suggest opposite. aim this study was investigate change in Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus strains three cross-sectional periods Türkiye, first before COVID-19 pandemic, second third during pandemic....