Background. The Lenses and Overnight Orthokeratology (LOOK) study is a pilot designed to learn the procedures of orthokeratology lens fitting in preparation for planned larger clinical trial obtain data with which calculate sample size that study. Data are presented first 3 months LOOK Methods. Sixty subjects were enrolled this multicenter evaluate success safety treatment overnight contact lenses. Refractive error, corneal topography, biomicroscopic collected determine amount refractive...

The multicenter Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a prospective, observational study 1209 keratoconus patients. We report methods to define incident corneal scarring and baseline factors predictive in nonsurgical eyes CLEK patients through their fifth year follow-up. Of the 1,209 patients, 878 with at least one unscarred cornea were included this study. cumulative 5-year incidence defined as proportion who developed central opacification detected by...

Soft contact lenses have been reported to increase the progression of myopia. The purpose this study was determine whether soft affect myopia in children.Children between ages 8 and 11 years with -1.00 -6.00 D less than 1.00 astigmatism were randomly assigned wear (n = 247) or spectacles 237) for 3 years. Refractive error corneal curvatures measured annually by cycloplegic autorefraction, axial length A-scan ultrasound. Multilevel modeling used compare rate change refractive error,...

Children are not offered elective contact lenses as a treatment option for refractive error nearly often teens are. The purpose of this report was to examine the benefits lens wear children and determine whether benefit much teens. If they do, should routinely be error.Neophyte wearers were categorized (8-12 years age) or (13-17 age). They completed Pediatric Refractive Error Profile (PREP), pediatric quality-of-life survey subjects affected only by error, while wearing glasses; then fitted...

To determine whether contact lens wear affects children's self-perceptions.The Adolescent and Child Health Initiative to Encourage Vision Empowerment Study was a randomized, single-masked trial conducted at five clinical centers in the United States. Subjects were 8- 11-year-old myopic children randomly assigned spectacles (n = 237) or soft lenses 247) for 3 years. The primary endpoint Self-Perception Profile Children Global Self-Worth scale. Secondary outcomes included Physical Appearance,...

Purpose. Innovations in contact lens materials and designs allow patients to wear lenses during sleep flatten the cornea temporarily reduce myopic refractive error improve unaided visual acuity. We conducted Children's Overnight Orthokeratology Investigation (COOKI) pilot study, a case series, describe changes, as well slitlamp observations associated with overnight orthokeratology children, over period of 6 months. Methods. Twenty-nine 8- 11-year-old children myopia between −0.75 −5.00 D...

Several studies have shown that children are capable of wearing and caring for contact lenses, but it is not known whether the benefits outweigh risks associated with lens wear. The purpose this article to compare vision-related quality life randomized wear spectacles or lenses 3 years using Pediatric Refractive Error Profile.The Profile was administered 484 who wore glasses at baseline. were then randomly assigned (n = 247) 237) years. survey baseline examination, 1 month, every 6 months...

Purpose. Despite several studies that show 8- to 11-year-old children are capable of wearing a various contact lens modalities, parents often report their eye care practitioner would not fit child with lenses until the was about 13 years old. We conducted Contact Lenses in Pediatrics (CLIP) Study compare fitting and follow-up between 12-year-old 13- 17-year-old teenagers. Methods. At baseline visit, all subjects underwent fitting, including visual acuity, manifest refraction, autorefraction,...

Background: Concerns regarding the safety of cosmetically tinted contact lenses have been reported in literature. The purpose this paper is to evaluate a large number patients across six clinical trials that varied from 1 week 3 months duration. Methods: Lenses tested included: Naturelle limbal ring daily disposable, Lacelle colored cosmetic planned replacement at 2 weeks, and Alamode traditional/annual lens. primary outcome was slit-lamp examination, including epithelial edema, microcysts,...

Multi-purpose solutions (MPSs) are designed to clean, disinfect, and condition contact lenses (CLs) reduce the risk of lens-related adverse events, such as corneal infiltrative events (CIEs) that often associated with opportunistic bacteria from contaminated CLs or CL cases. This study evaluated disinfection efficacies six MPSs one hydrogen peroxide solution (HPS) comparator against three lens case CIE-associated organisms. The in this were commonly isolated Gram-negative organisms presence...

Purpose. The purpose of this study was to describe the baseline characteristics subjects and methods for a multicenter, randomized clinical trial compare effects contact lens wear spectacle on children's self-perception. Methods. Eligible are randomly assigned glasses or lenses throughout 3-year study. Self-perceptions measured 1 month after randomization every 6 months using Self-Perception Profile Children (SPPC). Children's satisfaction with spectacles refractive error-related visual...

Background. Although previous contact lens myopia control studies indicate that rigid lenses slow the progression of in children, they have all suffered from limitations challenge significance their results. The Contact Lens and Myopia Progression (CLAMP) Study addresses attempts to correct them by implementing alternative designs. CLAMP study also measures ocular components examine potential mechanism treatment effect. Methods. Eligible children were fitted with gas-permeable enrolled a...

To describe the regression of treatment (i.e., return toward baseline refractive error findings) after with corneal therapy (CRT).After 6 to 9 months by a standardized protocol for CRT (application high-Dk, proximity control, zone contact lenses overnight reduction myopia), was measured within hours awaking and at 8, 24, 48, 72 hours. Comparison is analyzed in four categories achieved treatment. Logarithm minimum angle resolution visual acuity also measured.In general, returns all ranges...

Purpose. The Study of Progression Adult Nearsightedness (SPAN) is a 5-year observational study to determine the risk factors associated with adult myopia progression. Candidate include: high proportion time spent performing near tasks, tasks at close distance, accommodative convergence/accommodation (AC/A) ratio, and lag. Methods. Subjects between 25 35 years age, least –0.50 D spherical equivalent (cycloplegic autorefraction), were recruited from faculty staff Ohio State University. defined...

To compare children's reports of comfort, vision, and contact lens-related issues in gas permeable (GP) soft (SCL) lens wearers.Subjects were 116 8- to 11-year old children the Contact Lenses Myopia Progression Study. Aspects wear compared for remaining their original treatment group (either GPs or SCLs) 3 years. Questionnaires completed at every visit, as was visual acuity. Comparisons made between two groups using logistic regression mixed linear models analyses appropriate examine wearing...

Purpose: The aim was to compare vision correction wearing time between myopic children and teenagers in a clinical trial of contact lenses spectacles.Methods: Parents subjects the Adolescent Child Health Initiative for Vision Empowerment (ACHIEVE) study provided times spectacle lens wear. Hours primary total were compared two treatment groups. Other factors hypothesised be associated with analysed.Results: average differed significantly spectacles group being 91.5-hours per week 80.3-hours...

This case series presents the first documented cases of infectious ulcers associated with overnight orthokeratology in North America and other less serious complications corneal reshaping.Five adverse events refractive therapy are described: two microbial keratitis, one infiltrates, toxic abrasion.Corneal compromise poor compliance can cause reshaping. The need for ongoing patient education is important not only pediatric contact lens patients, but also adults.

Research has indicated that there is a correlation between the molecular weight of hyaluronan or hyaluronic acid (HA) and its biocompatibility/biological functions with high HA showing many biological benefits. The purpose this research was to characterize compare weights, distributions, concentrations present in series commercially available HA-containing ophthalmic products.On-line size-exclusion chromatography triple detection (SEC-TD) used determine weights concentration products,...

Abstract Aim: A study was conducted to assess the feasibility of experience sampling method (ESM) quantify daily visual tasks children. Methods: Thirty‐one children (9–14 years old, 39% male) were randomly paged after school (four times per day) and on weekends (eight for seven consecutive days. When paged, completed a voicemail survey regarding nature, duration, working distance type correction worn during activity. Responses subjects grouped into 14 categories. Before beginning paging,...