A5014581378- Congenital Diaphragmatic Hernia Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Congenital Anomalies and Fetal Surgery
- Urological Disorders and Treatments
- Tracheal and airway disorders
- ECG Monitoring and Analysis
- Cardiovascular Issues in Pregnancy
- Blind Source Separation Techniques
- Tumors and Oncological Cases
- Pediatric Urology and Nephrology Studies
- Teratomas and Epidermoid Cysts
- Renal and Vascular Pathologies
- Maternal and fetal healthcare
- Birth, Development, and Health
- Phonocardiography and Auscultation Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Trauma and Injuries
- Clinical Nutrition and Gastroenterology
- Maternal and Perinatal Health Interventions
- Preterm Birth and Chorioamnionitis
National Center For Child Health and Development
2016-2025
Tohoku University
2013-2020
Hudson Institute
2019
John Wiley & Sons (United Kingdom)
2019
Abstract The aim of this study was to review fetoscopic laser photocoagulation (FLP), which ablates placental vascular anastomoses treat twin–twin transfusion syndrome (TTTS). A studies reporting on the procedures, outcomes, complications and nonconventional applications FLP for TTTS conducted. has been established as primary treatment monochorionic twin pregnancy associated with at 16–26 weeks. is only therapy that directly addresses underlying pathophysiology. recent technique modification...
In this paper, a new noninvasive method is proposed for automated estimation of fetal cardiac intervals from Doppler Ultrasound (DUS) signal. This based on novel combination empirical mode decomposition (EMD) and hybrid support vector machines-hidden Markov models (SVM/HMM). EMD was used feature extraction by decomposing the DUS signal into different components (IMFs), one which linked to valve motions, i.e. opening (o) closing (c) Aortic (A) Mitral (M) valves. The electrocardiogram (fECG)...
To report the pregnancy outcomes of patients with twin reversed arterial perfusion (TRAP) sequence treated by radiofrequency ablation (RFA).This was a retrospective study TRAP sequences in single center between March 2002 and February 2015. Forty underwent RFA expandable tines through multistep coagulation method 15 26 gestational weeks. The primary outcome neonatal survival to discharge.The overall pump 85%. rates monochorionic-monoamniotic (MCMA) pregnancies monochorionic-diamniotic were...
A new natural course of spontaneous twin anemia polycythemia sequence (TAPS) was clarified. 29-year-old woman, who conceived monochorionic diamniotic twins, showed elevation the peak systolic velocity middle cerebral artery (MCA-PSV) in one at 24+2 weeks. The other a decrease MCA-PSV. amniotic volume did not differ between twins. We diagnosed them with TAPS. Four days later, maximum vertical pockets were 19 and 97 mm donor recipient, respectively. twin-twin transfusion syndrome, Quintero...
Abstract We evaluated the outcomes and adverse events after fetoscopic laser surgery (FLS) for twin–twin transfusion syndrome (TTTS) using Solomon technique in comparison to selective technique. A retrospective analysis of a single-center consecutive cohort FLS-treated TTTS (January 2010 July 2014) (August 2014 December 2017) techniques was performed. Among 395 cases, 227 underwent coagulation 168 The incidence rates recurrent (Solomon vs. selective: 0% .9%, p = .510) twin...
Twin anemia-polycythemia sequence (TAPS) is characterized by large inter-twin hemoglobin value differences without amniotic fluid discordance. The management of post-laser TAPS remains controversial. Hence, more studies on TAPS, together with the associated maternal complications and outcome fetuses infants are needed. Between 2003 2012, we performed 287 cases fetoscopic laser photocoagulation for twin-twin transfusion syndrome. Among 114 who were placed under our care until delivery, three...
Abstract Background Data on neurodevelopmental outcomes of children surviving after fetoscopic laser surgery (FLS) for twin‐to‐twin transfusion syndrome (TTTS) are scarce. Methods We retrospectively investigated FLS TTTS at 16 to 26 weeks' gestation between 2003 and 2014. Children were evaluated by standardized neurologic examinations using the Kyoto Scale 2001 a corrected age 3 years ± 6 months. Neurodevelopmental impairment (NDI) was defined as cerebral palsy (CP), bilateral blindness,...
Abstract Chronic histiocytic intervillositis (CHI) is an extremely rare pathological condition but strongly associated with severe obstetric complications and has a high recurrence rate. The management of this not yet been established. We describe herein the occurrence CHI in late second–third trimester each three consecutive pregnancies single patient four previous early miscarriages. In patient, complicated was managed one following, respectively: low‐dose aspirin; heparin plus...
To assess long-term neurodevelopmental outcomes in children after radiofrequency ablation (RFA) for twin reversed arterial perfusion (TRAP) sequence.This cross-sectional study included who underwent RFA the TRAP sequence between 2012 and 2018. We assessed neurodevelopment using Kinder Infant Development Scale, a validated questionnaire. The developmental quotient (DQ) nine subscales was calculated as age divided by chronological age. Neurodevelopmental delay (NDD) defined DQ of <70 points.In...
Right-sided, congenital diaphragmatic hernia is not common but accounts for about 20% of all hernia.It sometimes has serious complications, such as intrathoracic kidney and hepatic pulmonary fusion.Here we report a rare case right-sided hernia, complicated by fusion.Repair the diaphragm via abdominal approach was difficult disease recurred.The second operation through right thoracotomy successful.The biopsied specimen contained hepatocytes bile duct cells which strongly suggested close...
In this paper a new noninvasive method is proposed for automated estimation of opening and closure timings fetal cardiac valves. These are obtained from Doppler Ultrasound (DUS) signal electrocardiogram (fECG) as reference. Empirical Mode Decomposition (EMD) first applied to the DUS decompose it into different components called Intrinsic Functions (IMFs). The envelope IMF then taken its peaks identified. valves automatically assigned by using Hidden Markov Model (HMM). It shown that can...
Fetal Electrocardiography (FECG) offers unique capabilities for assessment of beat-to-beat fetal heart rate (FHR) and variability (FHRV), which are indirect markers autonomic nervous system, its development. In this study the ECG signals, FHR FHRV successfully recorded to assess neurodevelopment in mice second third trimester from days 12.5 18.5 by using direct insertion electrodes uterine. increases day till 15.5 reaching a plateau then shows sudden increase on 18.5. Development increasing...
Abstract Aim To present the feasibility, safety and outcomes of fetoscopic endoluminal tracheal occlusion (FETO) for treatment severe congenital diaphragmatic hernia (CDH). Methods This was a single‐arm clinical trial FETO isolated left‐sided CDH with liver herniation Kitano Grade 3 stomach position (>50% into right chest). performed at 27–29 weeks gestation cases observed/expected lung to head ratio (o/e LHR) <25% 30–31 o/e LHR ≥25%. Results Eleven were enrolled between March 2014...
To assess the role of lung size and abnormal Doppler findings in umbilical artery (UA) determining outcomes fetuses with primary fetal hydrothorax (FHT) associated hydrops who underwent thoracoamniotic shunting (TAS).This was a retrospective study at single center. We included cases FHT TAS our hospital between 2004 2016. assessed relationship mortality until 28 days after birth ultrasound findings, including absent or reversed end-diastolic velocity (AREDV) UA lung-to-thorax transverse area...
What's already known about this topic? Sudden fetal death and a non‐reassuring status are more frequent in gastroschisis. Many studies were undertaken to determine what findings may predict postnatal outcome, but few assessed the related risk. What does study add? Fetal gastroschisis with stomach herniation is associated high risk of or status.
Abstract Aim This study investigated the feasibility and safety of fetoscopic laser photocoagulation (FLP) for amniotic fluid discordance (AFD) bordering on twin–twin transfusion syndrome (TTTS) with an absent or reverse end‐diastolic velocity (AREDV) in umbilical artery (UA), evaluated perinatal long‐term outcomes. Methods A prospective intervention was performed between 20 + 0 25 6 weeks gestation (UMIN000004165). AFD TTTS defined as maximum vertical pocket (MVP) one twin's sac ≤3 cm MVP...
Double duodenal atresia is a rare disease and twenty-two cases have been reported in the English literature. We report here case of double that had suspected by fetal ultrasonography as polyhydramnios large cyst at right upper abdomen. Two membranous diaphragms duodenum separated lumen formed cystic lesion. Surgical reconstruction was performed.
The development of the fetal cardiovascular system plays a crucial role in health. evolution relationship between and maternal cardiac systems during maturation is characterizing feature for development. This paper aims to evaluate this by investigating beat-to-beat synchronization heart rates its variation at different stages pregnancy. Synchronization epochs phase locking patterns are analyzed certain ratios (SRs) three gestational age groups (16-26 weeks, 27-33 34-40 weeks). Results show...
Umbilical venous flow volume (UVFV) measured using ultrasound can be used to assess placental circulation in a fetus. UVFV at the intra-abdominal portion half maximum velocity of umbilical vein (UV) has good reproducibility with low variance. However, reference values previous reports were based on small number cases wide range. In present study, we evaluated standard normal Japanese fetuses.Measurements performed pregnant women during routine screening around 20 or 30 weeks gestation. The...
To examine the incidence of umbilical cord ulcer (UCU) that causes intrauterine fetal death (IUFD) in duodenal or jejunoileal atresia and association between UCU bile acid concentrations amniotic fluid.Perinatal outcomes were evaluated cases intestinal 2003 2017. A pathological examination was performed, fluid measured.Among 46 included this study, there 27 with 19 atresia. There 4 (8.7%) IUFD 1 (2.2%) neonatal multiple structural anomalies. UCUs found 37.5% (15/40) cases, severe exposed...
To examine the outcomes of prenatally diagnosed lower urinary tract obstruction (LUTO) with current management using vesicoamniotic shunting (VAS).A retrospective study LUTO before 26 weeks gestation at two tertiary centers in Japan between March 2002 and September 2017. was by ultrasound demonstration an enlarged fetal bladder associated hydronephrosis and/or hydroureters. VAS offered for fetuses ≤26 gestational age, presence oligohydramnios or decreasing amniotic fluid a favorable...