A5047254204- Electrical Contact Performance and Analysis
- Railway Engineering and Dynamics
- Railway Systems and Energy Efficiency
- Immune Response and Inflammation
- Mechanical stress and fatigue analysis
- S100 Proteins and Annexins
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Acute Ischemic Stroke Management
- Elevator Systems and Control
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Adhesion, Friction, and Surface Interactions
- Respiratory Support and Mechanisms
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Biomarkers in Disease Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Nanoplatforms for cancer theranostics
- Trauma and Emergency Care Studies
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Chinese PLA General Hospital
2016-2025
China Academy of Railway Sciences
2021-2025
Zhengzhou University
2024-2025
Henan Academy of Sciences
2025
Lanzhou University
2025
First Hospital of Lanzhou University
2025
Southwest Jiaotong University
2020-2021
Monash University
2020-2021
Hebei Medical University
2021
Second Hospital of Hebei Medical University
2021
To investigate whether XueBiJing injection improves clinical outcomes in critically ill patients with severe community-acquired pneumonia.Prospective, randomized, controlled study.Thirty-three hospitals China.A total of 710 adults 18-75 years old pneumonia.Participants the group received XueBiJing, 100 mL, q12 hours, and control a visually indistinguishable placebo.The primary outcome was 8-day improvement pneumonia severity index risk rating. Secondary were 28-day mortality rate, duration...
A complete track-vehicle-pantograph-catenary (TVPC) coupling dynamics model is presented and several elaborate simulation cases are set to analyse the effect of vehicle body vibration on pantograph-catenary system (PACS). The catenary described by a finite-element while pantograph, track multi-body model. In addition, different irregularities introduced mimic real conditions. Through Pearson correlation coefficient spectrum analysis, key kinematics parameters identified, which influence both...
Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune plays central role in the pathogenesis of sepsis. Dendritic cells (DCs) play crucial emergence The major manifestations DCs septic state are abnormal functions and depletion numbers, which linked higher mortality vulnerability secondary infections Apoptosis most widely studied pathway number reduction DCs. In past few years, there has been...
Although the abilities of omentum to alleviate inflammation and prevent infection have been revealed over past decades, underlying mechanisms remain largely unelucidated. Here, we demonstrated that mortality mice exposed cecal ligation puncture (CLP) omentectomy was remarkably increased compared those treated with CLP alone. Moreover, efficacy associated an impairment in intraperitoneal bacterial clearance together increase expression proinflammatory cytokines. Besides, response peritoneal...
Cerebral small vessel disease (CSVD) is a global brain disorder that characterized by series of clinical, neuroimaging, and neuropathological manifestations. However, the molecular pathophysiological mechanisms CSVD have not been thoroughly investigated. Liquid chromatography-tandem mass spectrometry-based proteomics has broad application prospects in biomedicine. It used to elucidate disease-related processes pathways, thus providing an important opportunity explore CSVD. Serum samples were...
Abstract After injury, the imbalance of regeneration microenvironment caused by inflammation, oxidative stress, insufficient neurovascularization, and inadequate energy supply affects nerve regeneration. Drug‐delivery conduits play a role in repairing regenerative microenvironment. However, traditional drugs often fail to cross blood‐nerve barrier lack multifunctionality, limiting effectiveness conduit therapy. Therefore, it is necessary construct multifunctional that regulate timely...
Two subgroups with high expression of B7-H1 and low were successfully isolated from primitive human umbilical cord mesenchymal stem cells. And exosomes isolated. In comparison to the sham-operated group, mice in IRI group demonstrated elevated serum levels blood urea nitrogen (BUN) creatinine (Scr), accompanied by a more pronounced degree renal tissue damage. The administration via tail vein markedly accelerated recovery function mice, therapeutic effect beingmore those treated...
Autophagy plays a protective role in endotoxemic mice. Heat shock factor 1 (HSF-1) also crucial mice by decreasing inflammatory cytokines. The purpose of this study was to determine whether HSF-1 is involved attenuating the release cytokines lipopolysaccharide (LPS)-stimulated and peritoneal macrophages (PMs) through regulating autophagy activity. Autophagosome formation HSF-1+/+ HSF-1-/- PMs stimulated LPS examined Western blotting immunofluorescence. Lipopolysaccharide-induced were treated...
Autologous fat injection is a common aesthetic procedure for soft-tissue augmentation of the face. Although this generally regarded as safe, several patients have experienced acute visual loss or cerebral infarction after these injections. We describe case internal and external carotid artery embolism that occurred following autologous into It appeared injected entered branch left embolus likely migrated distally ophthalmic artery, anterior middle artery. LEVEL OF EVIDENCE 5:
Mesenchymal stem cells (MSCs), as a kind of pluripotent adult cell capable exhibiting immunomodulatory properties, have been extensively studied in basic scientific research and clinical applications inflammatory diseases. MSC-derived extracellular vesicles (MSC-EVs) are receiving increasingly attention major pathway for MSCs to exert intercellular communication. It has demonstrated that programmed death (PCD) plays critical role the pathophysiology human diseases, mainly including...
Ice coating on overhead contact system (OCS) will affect the sliding of pantograph, and arc discharge phenomena occur between pantograph catenary, which threaten normal operation train. This paper presents a comprehensive model to analyze dynamics icing pantograph-catenary (PAC) system. The finite element (FEM) is used for building modeled as lumped-mass model, ice section cable fan-shaped. increased density method, uniform load combinatorial material method are problem PAC similarities...
This paper examines the dynamic performance of pantograph passing through an overlap section catenary system, using a China's high speed railway with 4-span as example. The and system are simulated lumped mass model finite element model, respectively. is verified according to EN50318:2018. also assessed against experimental study contact force uplift wire at 300 km/h. Then 150–350 km/h calculated. research shows that when passes overlap, maximum increases beyond 14%, standard deviation by...
Abstract Despite various biomaterial‐based strategies are tried in spinal cord injury (SCI), developing safe and effective microinvasive pharmacotherapy is still an unmet clinical need. Stimuli‐responsive nanomedicine has emerged as a promising non‐invasion technology, which enhances drug delivery promotes functional recovery following SCI. Considering the multiple progressive pathological events blood barrier (BSCB) associating SCI, microenvironment self‐adaptive nanoparticle...
This paper investigates the effect of ambient temperature change on dynamic interaction between pantograph and catenary (PAC). Thermal expansion/contraction components overhead contact system (OCS) is considered. Simulation results show that thermal stress has a much greater influence longitudinal positioning wire than horizontal vertical positioning. When reduces to [Formula: see text] from design text]C, maximum displacement positioner can reach as high 301 mm, while within 4[Formula:...