A5077811982- Pancreatic and Hepatic Oncology Research
- Foot and Ankle Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lower Extremity Biomechanics and Pathologies
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Lung Cancer Treatments and Mutations
- Viral gastroenteritis research and epidemiology
- Oral and Maxillofacial Pathology
- Lung Cancer Research Studies
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- Numerical methods in engineering
- Gastric Cancer Management and Outcomes
- Electrocatalysts for Energy Conversion
- Antenna Design and Analysis
- Renal cell carcinoma treatment
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
- Congenital heart defects research
- Trace Elements in Health
- NF-κB Signaling Pathways
- Advanced Wireless Communication Technologies
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
Third Affiliated Hospital of Southern Medical University
2022-2025
University of Chinese Academy of Sciences
2024-2025
Shanghai Jiao Tong University
2017-2025
Second Affiliated Hospital of Guangzhou Medical University
2024-2025
Guangzhou Medical University
2024-2025
China Agricultural University
2025
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
A novel coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—emerged in humans Wuhan, China, December 2019 and has since disseminated globally1,2. As of April 16, 2020, the confirmed case count disease (COVID-19) had surpassed million. Based on full-genome sequence analysis, SARS-CoV-2 shows high homology to SARS-related coronaviruses identified horseshoe bats1,2. Here we show establishment characterization expandable intestinal organoids derived from bats Rhinolophus...
Reconstructing extensive cranial defects represents a persistent clinical challenge. Here, we reported hybrid three-dimensional (3D) printed scaffold with modification of QK peptide and KP for effectively promoting endogenous bone regeneration. The 3D consists vertically aligned cryogel fibers that guide promote cell penetration into the defect area in early stages repair. Then, conjugated further regulate function recruited cells to vascularization osteogenic differentiation area....
Sleep duration and physical activity (PA) are critical factors influencing mortality risk. However, the interaction between sleep PA with risk among cancer survivors has not been well explored. This cross-sectional study utilized data from National Health Nutrition Examination Survey (NHANES) spanning 2007-2018. Multivariable Cox regression analysis restricted cubic splines were employed to evaluate hazard ratios (HRs) 95% confidence intervals (CIs) of association in survivors....
Aim: To analyze the m6A methylome of osteosarcoma stem cells (OSCs). Materials & methods: Chemoresistant OSCs were enriched by doxorubicin treatment. Expression m6A-related enzymes was detected quantitative real-time-PCR and western blot. MeRIP-seq RNA-seq performed to identify differences in methylation gene expression. Data analysis conducted explore modified genes their clinical significance. Results: Three altered OSCs. Differentially methylated some pathways regulating pluripotency...
Enteroviruses, such as EV-A71 and CVA16, mainly infect the human gastrointestinal tract. Human coronaviruses, including SARS-CoV SARS-CoV-2, have been variably associated with symptoms. We aimed to optimize intestinal organoids hypothesize that these optimized can recapitulate enteric infections of enterovirus coronavirus. demonstrate enable better simulation native epithelium, they are significantly more susceptible than CVA16. Higher replication CVA16 in triggers a vigorous cellular...
Abstract A highly biomimetic neotrachea with C‐shaped cartilage rings has promising clinical applications in the treatment of circumferential tracheal defects (CTDs) owing to its structure and physiological function. However, date, most fabricated cartilages are O‐shaped. In this study, finite element analysis demonstrates that exhibit better compliance than Hydrogel is developed using methacryloyl‐modified decellularized Wharton's jelly matrix (DWJMA) for regeneration rings. This novel...
Abstract Critical‐sized segmental long bone defects represent a challenging clinical dilemma in the management of battlefield and trauma‐related injuries. The residual marrow cavity damaged bones contains many mesenchymal stem cells (BMSCs), which provide substantial source for repair. Thus, three‐dimensional (3D) vertically aligned nanofiber scaffold (VAS) is developed with channels large pore size. VAS toward after transplantation, enables scaffolds to recruit BMSCs from defect area. In...
Abstract Infected bone defects are a common clinical condition, but conventional treatments often fail to achieve the desired outcomes, including addressing antibiotic resistance and preventing nonunion complications. In presented study, functionalized decellularized mushroom stem scaffold is developed composed of its naturally aligned channels, Zn 2+ /curcumin MOFs, hydroxyapatite minerals, icariin. vitro, It found that acellular can control bacterial infections through MOFs. The channels...
Silicon (Si) is a beneficial nutrient well-known for its functions in enhancing plant resistance to abiotic and biotic stresses. How Si application affects tomato yield quality underlying physiological mechanisms remain largely unclear. Our pot experiment showed that (45 kg ha⁻¹ Na₂SiO₃) significantly promoted accumulation of nitrogen, phosphorus, potassium, the shoot soil-cultured greenhouse. Such improved mineral nutrition favored Si-applied performance terms height, stem diameter, single...
Rayleigh wave exploration is widely used in the field of engineering investigation, which can analyze near surface velocity structure. However, traditional data processing method only provide average change phase with depth under seismic line, but cannot obtain horizontal along line direction, brings great challenges to detection underground anomalies. To solve these problems, Choi‒Williams distribution introduced process waves, and relationships among time, frequency amplitude are obtained....
Objective The effectiveness of autologous osteoperiosteal transplantation (AOPT) for the treatment large cystic talar osteochondral lesions (OCLs) should be further evaluated, and postoperative cartilage coverage is questionable. purpose this retrospective observational study was to investigate clinical outcomes AOPT OCLs report second‐look arthroscopic results. Methods From June 1, 2017, 2021, all at our center were reviewed. Painful treated with included in study. American Orthopaedic Foot...
Abstract Immunotherapy is widely used in cancer treatment; however, only a subset of patients responds well to it. Significant efforts have been made identify who will benefit from immunotherapy. Successful anti-tumor immunity depends on an intact cancer-immunity cycle, especially long-lasting CD8 + T-cell responses. Interferon (IFN)-α/β/IFN-γ/interleukin (IL)-15 pathways reported be involved the development T cells. And these may predict responses Herein, we aimed analyze multiple public...
There has been increasing application of autologous costal chondral/osteochondral transplantation (ACCT/ACOT) and costa‐derived chondrocyte implantation (ACCI) for articular cartilage repair over the past three decades. This review presents major evidence on properties bone their qualifications as grafts repair, clinical applications, risks strategies graft(s) harvest. First, many specific that help restore surface. Costa, which can provide abundant cylindrical corticocancellous bone,...
Two types of suture anchor insertion pathways (anterolateral portal vs lateral accessory portal) are used in arthroscopic anterior talofibular ligament (ATFL) repair. However, it is not clear which one the better choice. This study aims to compare clinical outcomes these 2 when performing ATFL lasso-loop repair for treatment chronic ankle instability (CLAI).
Osteochondral lesions of the talus (OLT) is a common and clinically challenging disease. The optimal management still under debate. purpose this prospective study was to investigate feasibility clinical outcomes autologous costal osteochondral transplantation (ACOT) for treatment cystic OLT.From November 2021 April 2023, five patients underwent OLT. demographic data described, including age, gender, lesion size location. We prospectively evaluated their functional imaging 12 months...
Reconfigurable intelligent surface (RIS) is one of the promising technologies for sixth generation communications due to its advantages including energy saving, high spectral efficiency, etc. However, non-convex joint beamforming design a challenge, especially in multi-hop RIS-assisted communication system. This paper proposes deep learning-based (DLBF) design, aiming maximize system data rate RIS-aided systems. The proposed DLBF consists reflection matrices all RISs and transmit at base...
ABSTRACT Introduction Immunotherapy has revolutionized the management of lung cancer and improved survival in trials, but its real‐world impact at population level remains unclear. Methods Using data obtained from eight Surveillance, Epidemiology, End Results (SEER) registries 2004 through 2019, we addressed long‐term trends incidence, incidence‐based mortality (IBM), patients United States. The incidence IBM both non–small cell (NSCLC) small (SCLC) all significantly decreased steadily to...
The iliac crest is the most common autogenous bone graft donor site, although associated with postoperative pain, functional disability, cosmesis, morphology and surgical satisfaction. We assessed each aspect above by comparing reconstruction cement screws following harvest no reconstruction.We evaluated patients who underwent large harvesting, including ten defect cancellous (R group) randomly matched without (NR were prospectively in same period. Local cosmesis other complications...
Objective To find novel potential gene mutations other than EXT1 and EXT2 mutations, to expand the mutational spectrum of EXT explore correlation between clinical outcome genotype in patients with hereditary multiple exostoses (HME). Methods The study recruited seven families diagnosed osteochondromas (MO). Family histories information were collected detail through comprehensive physical image examination. Patients deformities functional limitations classified as “severe” remaining without...