A5054616674- Bat Biology and Ecology Studies
- Viral Infections and Vectors
- Yersinia bacterium, plague, ectoparasites research
- Environmental Toxicology and Ecotoxicology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Bacillus and Francisella bacterial research
- Effects of Environmental Stressors on Livestock
- Rabies epidemiology and control
- Mercury impact and mitigation studies
- Marine animal studies overview
- Toxic Organic Pollutants Impact
- Insect and Pesticide Research
- Physiological and biochemical adaptations
- Animal Ecology and Behavior Studies
- Pesticide Exposure and Toxicity
- Cholinesterase and Neurodegenerative Diseases
- Evolution and Paleontology Studies
- Aquaculture disease management and microbiota
- Heavy Metal Exposure and Toxicity
- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Aquatic Ecosystems and Biodiversity
- Toxoplasma gondii Research Studies
- Pesticide and Herbicide Environmental Studies
- Poxvirus research and outbreaks
University of Veterinary Sciences Brno
2016-2025
Mendel University in Brno
2021-2025
Masaryk University
2008
TOS Kuřim (Czechia)
2005
Abstract A striking feature of white-nose syndrome, a fungal infection hibernating bats, is the difference in outcome between North America and Europe. Here we show high WNS prevalence both Europe on West Siberian Plain Asia. Palearctic bat communities tolerate similar loads Pseudogymnoascus destructans as their Nearctic counterparts histopathology indicates equal focal skin tissue invasiveness pathognomonic for lesions. Fungal load positively correlates with disease intensity it reaches...
Definitive diagnosis of the bat disease white-nose syndrome (WNS) requires histologic analysis to identify cutaneous erosions caused by fungal pathogen Pseudogymnoascus [formerly Geomyces] destructans (Pd). Gross visual inspection does not distinguish bats with or without WNS, and no nonlethal, on-site, preliminary screening methods are available for WNS in bats. We demonstrate that long-wave ultraviolet (UV) light (wavelength 366-385 nm) elicits a distinct orange-yellow fluorescence...
Host traits and phylogeny can determine infection risk by driving pathogen transmission its ability to infect new hosts. Predicting such risks is critical when designing disease mitigation strategies, especially as regards wildlife, where intensive management often advocated or prevented economic and/or practical reasons. We investigated Pseudogymnoascus [Geomyces] destructans infection, the cause of white-nose syndrome (WNS), in relation chiropteran ecology, behaviour phylogenetics. While...
White-nose syndrome, associated with the fungal skin infection geomycosis, caused regional population collapse in bats North America. Our results, based on histopathology, show presence of white-nose syndrome Europe. Dermatohistopathology two (Myotis myotis) found dead March 2010 geomycosis Czech Republic had characteristics resembling Geomyces destructans confirmed US hibernacula. In addition, a live M. myotis, biopsied for histopathology during hibernation April 2011, typical cupping...
Abstract Pathogenic and non-pathogenic related microorganisms differ in secondary metabolite production. Here we show that riboflavin overproduction by a fungal pathogen its hyperaccumulation affected host tissue exacerbates skin infection to necrosis. In white-nose syndrome (WNS) lesions caused Pseudogymnoascus destructans , maximum concentrations reached up 815 μg ml −1 indicating bioaccumulation lack of excretion. We found high are cytotoxic under conditions specific for hibernation,...
While white-nose syndrome (WNS) has decimated hibernating bat populations in the Nearctic, species from Palearctic appear to cope better with fungal skin infection causing WNS. This encouraged multiple hypotheses on mechanisms leading differential survival of exposed same pathogen. To facilitate intercontinental comparisons, we proposed a novel pathogenesis-based grading scheme consistent WNS diagnosis histopathology criteria. UV light-guided collection was used obtain single biopsies...
While Pseudogymnoascus destructans has been responsible for mass bat mortalities from white-nose syndrome (WNS) in North America, its virulence Europe questioned. To shed the light on issue of host–pathogen interaction between European bats and P. destructans, we examined seventeen emerging fungus-positive underground hibernacula Czech Republic during early spring 2013. Dual wing-membrane biopsies were taken Barbastella barbastellus (1), Myotis daubentonii emarginatus myotis (11), nattereri...
The purpose of the present study was to employ two methods-square wave voltammetry (SWV) performed on screen printed sensors and ferric reducing antioxidant power (FRAP)-as suitable tools for assay low-molecular-weight antioxidants (LMWAs). LMWAs were assayed by both methods resulting data statistically compared. Plasma samples from five Cinereous vultures accidentally intoxicated with lead used represent real biological matrices different levels LMWAs. Blood collected birds prior one month...
Lead, a serious threat for raptors, can hamper the success of their conservation. This study reports on experience with accidental lead intoxication and responses to chelation therapy in captive Cinereous (Aegypius monachus) Egyptian (Neophron percnopterus) Vultures. Soil contamination by lead-based paint sanded off steel aviary resulted poisoning eight two A male Vulture developed signs apathy, polydipsia, polyuria, regurgitation, stupor, died next day. Liver, kidney blood concentrations...
Abstract In underground hibernacula temperate northern hemisphere bats are exposed to Pseudogymnoascus destructans , the fungal agent of white-nose syndrome. While pathological and epidemiological data suggest that Palearctic tolerate this infection, we lack knowledge about bat health under pathogen pressure. Here report blood profiles, along with body mass index (BMI), infection intensity hibernation temperature, in greater mouse-eared ( Myotis myotis ). We sampled three European differ...
Understanding how context (e.g., host species, environmental conditions) drives disease susceptibility is an essential goal of ecology. We hypothesized that in bat white-nose syndrome (WNS), species-specific host–pathogen interactions may partly explain varying outcomes among species. characterized and pathogen transcriptomes paired samples lesion-positive lesion-negative wing tissue from bats infected with Pseudogymnoascus destructans three parallel experiments. The first two experiments...
Abstract There has been growing interest in the study and conservation of bats throughout world. Declines their absolute numbers recent decades are due, part, to fact that insectivorous may bioaccumulate toxic pollutants. The purpose present was quantify heavy metal concentrations kidney, liver, pectoral muscle samples relation metallothionein (MT) levels. In total, 106 belonging 11 European species (i.e., Myotis myotis , daubentonii brandtii nattereri emarginatus mystacinus Pipistrellus...
Abstract Background The grey partridge is an important game bird in Europe that has declined considerably over the last decades. production and release of farm-bred birds can be threatened by infectious agents. objective this study was to describe outbreak, pathology, blood tissue biochemical responses a flock partridges naturally infected with Mycoplasma gallisepticum . Results Morbidity mortality rates were 100% 60%, respectively. Necropsy revealed accumulation caseous exudate within...
Vertebrate ectoparasites frequently play a role in transmission of infectious agents. Pseudogymnoascus destructans is psychrophilic fungus known to cause white-nose syndrome (WNS), an emerging disease bats. It transmitted with direct contact between bats or contaminated environment. The aim this study was examine wing mites from the family Spinturnicidae parasitizing hibernating for presence P. propagules as another possible route. Wing collected 33 at four hibernation sites Czech Republic...
Bats are found to be the natural reservoirs for many emerging viruses. In most cases, severe clinical signs caused by such virus infections normally not seen in bats. This indicates differences virus-host interactions and underlines necessity develop host related models study these phenomena. Due strict protection of European bat species, immortalized cell lines only alternative investigate innate anti-virus immune mechanisms. Here, we report about establishment functional characterization...
White-nose syndrome (WNS) is a fungal disease caused by Pseudogymnoascus destructans that devastating to Nearctic bat populations but tolerated Palearctic bats. Temperature factor known be important for growth and choice of hibernation. Here we investigated the effect temperature on pathogenic in wild across Palearctic. We modelled body surface bats with respect infection intensity severity were able relate this mean annual at site. Bats hibernated lower temperatures had less fewer skin...
While commercial poultry and captive birds are exposed to antimicrobials through direct medication, environmental pollution may result in contamination of wild birds. Fluoroquinolones commonly used medications treat severe avian bacterial infections; however, their adverse effects on remain understudied. Here, we examine toxicity enrofloxacin marbofloxacin during the egg incubation period using chicken (Gallus Gallus domesticus) as a model species. Laboratory tests were based eggs injected...
Significant mortalities associated with emerging viral diseases are challenging the economy of common carp aquaculture. As such, there is an increased need to disentangle how infected fish cope progressive disease pathology and lose ability for homeostatic maintenance key physiological parameters. A natural edema virus (CEV) infection outbreak at a farm provided opportunity examine diseased healthy in same storage pond, thereby contributing our better understanding CEV pathophysiology. The...