A5007442173- Phytochemistry Medicinal Plant Applications
- Carcinogens and Genotoxicity Assessment
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Photodynamic Therapy Research Studies
- Synthesis and Biological Evaluation
- Ion Transport and Channel Regulation
- Synthesis and Characterization of Heterocyclic Compounds
- Health and Lifestyle Studies
- Click Chemistry and Applications
- Business and Management Studies
- Cancer therapeutics and mechanisms
- Synthesis and bioactivity of alkaloids
- Antifungal resistance and susceptibility
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Natural product bioactivities and synthesis
- Identification and Quantification in Food
- Diet, Metabolism, and Disease
- Marine Sponges and Natural Products
- Free Radicals and Antioxidants
- Plant tissue culture and regeneration
- ATP Synthase and ATPases Research
- Research on Leishmaniasis Studies
Federal University of São João del-Rei
2014-2024
Midwestern State University
2012
Universidade Estadual Paulista (Unesp)
2006-2011
Centro Universitário de Araraquara
2007-2010
Universidade do Vale do Paraíba
2008-2009
Centre for Research and Development in Telecommunications (Brazil)
2009
Universidade Estadual de Londrina
2004-2008
CHU Dijon Bourgogne
2008
The present work is focussed on the principles of photodynamic therapy (PDT), emphasizing photochemical mechanisms reactive oxygen species formation and consequent biochemical processes generated by action various biological macromolecules organelles. This paper also presents some most used photosensitizers, including Photofrin, new prototypes analysing their physicochemical spectroscopic properties. At this point, review discusses therapeutic window absorption specific wavelengths involving...
The use of artificial implants provides a palliative or permanent solution for individuals who have lost some bodily function through disease, an accident natural wear. This functional loss can be compensated by the medical devices produced from special biomaterials. Titanium alloy (Ti-6Al-4V) is well-established primary metallic biomaterial orthopedic implants, but toxicity chemical components this has become issue concern. In work, we used MTT assay and micronucleus to examine cytotoxicity...
The present work focuses on the recent applications of Raman spectroscopy (RS) biochemical analysis and diagnosis several biological materials with or without pathological alterations. Important published works about its use for medical were critically reviewed, including articles form our group in order to evaluate state art subject. potential sample characterization RS associated possibility situ makes this instrumental technique a very auspicious tool analysis. can promote significant...
We analyzed the effect of hydroxyurea on JAK2V617F allelic ratio (%JAK2V617F), measured in purified blood granulocytes, patients with polycythemia vera and essential thrombocythemia. Thirty-six were examined sequentially prior to after start hydroxy-urea therapy (8 vera, 17 thrombocythemia), or while remaining untreated (2 9 thrombocythemia). Hydroxyurea (median duration: 15 months) reduced %JAK2V617F by >30% 13/25 (4 For 3 patients, remained undetectable for 3-27 months. In addition, a...
Despite the large use of Plantago major and Siparuna guianensis in traditional medicine, there are no studies demonstrating effectiveness from extracts these plants healing process by present methodology. This study reported effects toxicity P. S. wound compared with a commercial product used Brazil macroscopic microscopic analysis. Following injury cervical dorsal area mice, extract ointment was applied after an mice. Wound rates were calculated at 4, 9, 15 21 d wounding, tissues obtained...
Cardiotonic steroids are used to treat heart failure and arrhythmia have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. consist of nucleus lactone ring, their biological effects depend on the binding receptor, Na,K-ATPase, through which, they inhibit Na+ K+ ion transport activate several intracellular signaling pathways. In this study, we added styrene group ring digoxin, obtain 21-benzylidene digoxin...
The present work focuses on the recent applications of Raman spectroscopy (RS) biochemical analysis and diagnosis several biological materials with or without pathological alterations. Important published works about its use for medical were critically reviewed, including articles form our group in order to evaluate state art subject. potential sample characterization RS associated possibility analysisin situ makes this instrumental technique a very auspicious tool analysis. can promote...
Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian "cerrado" (tropical American savanna), and local population uses it to treat diseases, such as diarrhea gastric ulcer. It belongs Malpighiaceae family, commonly known "murici." Considering popular use of B. derivatives lack pharmacological potential studies regarding this vegetal species, mutagenic antimutagenic effect methanol (MeOH) chloroform extracts were evaluated by Ames test, using strains TA97a, TA98,...
Introdução: O sistema CEREC oferece um corpo de escaneamento que permite o intrabucal coroas implantossuportadas, dependendo da profundidade gengival do implante. software reconhece esses dispositivos quando eles são posicionados nas bases titânio CEREC. Antes escanear, implante precisa ser selecionado no software. Se a área for escolhida como “dente”, pilar comercial pode escaneado diretamente e, tendo todos os equipamentos necessários, clínico está apto para prosseguir com passos...
Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome.Based on ethnopharmacological data, methanolic extract from (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti-Helicobacter pylori activities.The gastroprotective action of rodent experimental models (HCl/ethanol, ethanol or NSAID). We also effect (Ames assay), pylori, anti-hemorrhagic action, analgesic inflammatory effects (hot-plate test carrageenin-induced...
Summary Photodynamic therapy (PDT) has been originally developed for cancer treatment, but recently, it successfully employed against microorganisms, including fungi. Chromoblastomycosis is a subcutaneous fungal infection that recalcitrant to conventional antifungal drug therapy. The most frequent species involved are Foncecaea pedrosoi and Cladophialophora carrionii . present study aimed verify the efficacy in vitro of PDT employing methylene blue (MB) as photosensitiser Light emmiting...
Cancer continues to be one of the most important health problems worldwide, and identification novel drugs treatments address this disease is urgent. During recent years, marine organisms have proven a promising source new compounds with action against tumoral cell lines. Here, we describe synthesis anticancer activity eight 3-alkylpyridine alkaloid (3-APA) analogs in four steps good yields. The key step for these Williamson etherification under phase-transfer conditions. We investigated...
The exact function of eosinophils in cancer, particularly oral squamous cell carcinoma (OSCC), has not yet been elucidated and the possible antitumor effect these leukocytes is associated with release cytotoxic proteins, eosinophil cationic protein (ECP). aim this study was to evaluate ECP on human OSCC lines provide novel insights into role tumors. viability SCC-4 SCC-25 assessed by colorimetric assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). cells were...
Some species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly South America and Africa. Several kinds biological activity have been seen species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines inhibitory to replication HIV-1 HIV-2. In Brazil, castaneaefolia Willd. A. Juss. glandulosa Poepp. & Endl. by local population treat rheumatism, arthritis muscular pains. view use these plants as medicines...
Studies evaluating the toxicity caused by fungal exopolysaccharides of β-(1-->6)-D-glucan type are rare. In this study, toxicological effects sub-chronic treatments with lasiodiplodan (β-(1-->6)-D-glucan from Lasiodiplodia theobromae MMPI) were evaluated in mice through assessment biochemical, hematological, and histopathological alterations. Thirty-two (16 male, 16 female) used study divided two groups; one group received (50 mg/kg body weight) daily for 28 days via gavage, another (control...
Photodynamic therapy (PDT) has been proved to be effective against fungi and it may employed as a coadjutant conventional antifungal agents, leading more microbial control minimising side effects. This work evaluates the combined effect of PDT fluconazole resistant Candida albicans, glabrata krusei. The yeasts were submitted methylene blue-PDT (MB-PDT) in sub-inhibitory concentrations. In present work, MB-PDT with was efficient inhibition C. albicans than each treatment alone, being possible...
Cardiotonic steroids (CS), natural compounds with traditional use in cardiology, have been recently suggested to exert potent anticancer effects. However, the repertoire of molecules Na,K-ATPase activity and properties is limited. This paper describes synthesis 6 new digoxin derivatives substituted (on C17-butenolide) γ-benzylidene group their cytotoxic effect on human fibroblast (WI-26 VA4) cancer (HeLa RKO) cell lines as well expression. As digoxin, compound BD-4 was almost 100-fold more...