A5088370547- Cardiovascular and exercise physiology
- Sports Performance and Training
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Physical Activity and Health
- Gallbladder and Bile Duct Disorders
- Heart Rate Variability and Autonomic Control
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Educational Games and Gamification
- Non-Invasive Vital Sign Monitoring
- Surgical site infection prevention
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Virtual Reality Applications and Impacts
- Child Abuse and Trauma
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Liver physiology and pathology
- Urinary Tract Infections Management
Institute for Sports Medicine
2025
University of Lucerne
2024
Heidelberg University
2008-2024
University Hospital Heidelberg
2009-2023
Technical University of Darmstadt
2014-2022
Martin Luther University Halle-Wittenberg
2022
Hopp Children's Cancer Center Heidelberg
2021
University Hospital Leipzig
2020
Sophien-und Hufeland Klinikum
2018
Serious games are digital that have an additional goal beyond entertainment. Recently, many studies explored different quality criteria for serious games, including effectiveness and attractiveness. Unfortunately, the double mission of is, simultaneous achievement intended effects (serious part) entertainment (game part), is not adequately considered in these studies. This paper aims to identify essential games. The fundamental our research important factors adapt existing principles...
Hepatitis C virus (HCV) infection is sensitive to interferon (IFN)-based therapy, whereas hepatitis B (HBV) not. It unclear whether HBV escapes detection by the IFN-mediated immune response or actively suppresses it. Moreover, little known on how and HCV influence each other in coinfected cells. We investigated interactions between using HepaRG cells primary human hepatocytes (PHHs). analyzed effects of replication, vice versa, at single-cell level.PHHs were isolated from liver resection...
Hepatitis C virus (HCV) infections most often result in chronic outcomes, although the constantly produces replication intermediates, particular double-stranded RNA (dsRNA), representing potent inducers of innate immunity. We aimed to characterize fate HCV dsRNA hepatocyte cultures identify mechanisms contributing viral persistence presence an active immune response.We analyzed hepatocyte-based culture models for induction immunity, secretion positive- or negative-strand RNA, and using...
Chronic liver diseases are worldwide on the rise. Due to rapidly increasing incidence, in particular Western countries, metabolic dysfunction-associated steatotic disease (MASLD) is gaining importance as can develop into hepatocellular carcinoma. Lipid accumulation hepatocytes has been identified characteristic structural change MASLD development, but molecular mechanisms responsible for progression remained unresolved. Here, we uncover primary from a preclinical model fed with diet (WD) an...
To determine perioperative and oncologic outcomes after distal pancreatectomy with en bloc resection of the celiac axis (DP-CAR).DP-CAR can be used in a selective group patients to resect locally advanced pancreatic cancer involving or common hepatic artery without arterial reconstruction by preserving retrograde blood flow via gastroduodenal liver stomach.We analyzed all consecutive who had undergone DP-CAR between May 2003 April 2022 at tertiary hospital specialized surgery present one...
Background: Peer-assisted learning (PAL) has become a well-accepted teaching method within medical education. However, descriptions of on-ward PAL programmes are rare. We introduced programme with focus on clinical competencies internal medicine wards.Aims: To assess the effects an self-assessed competencies.Method: A total 168 students were randomly assigned to one seven intervention wards or control wards. During their 5-week ward-placement, group (IG; n = 88) received 10 patient-centred...
Exergames have the potential to be used as physical-cognitive training tools. Although numerous studies investigated physical and motivational effects of Exergaming, a comprehensive summary in healthy adults is still missing. This scoping review aims identify available evidence research gaps on absolute relative Exergame indicators (effectiveness) motivation (attractiveness) compared no or conventional adults. A systematic literature search was performed EBSCOhost, WoS CC, SURF, Science...
The objective of this study was to identify the indications for and report outcomes completion pancreatectomy (CPLP) in postoperative course after pancreatoduodenectomy (PD).CPLP may be considered or even inevitable damage control PD.A prospectively maintained database all patients undergoing PD between 2001 2019 searched who underwent CPLP PD. Baseline characteristics, perioperative details, were analyzed specific identified.A total 3953 consecutive during observation period. performed 120...
This article presents a feasibility study of using an algorithm for individual and adaptive control training load in ergometer-controlled exergame aerobic training. An additional goal was to investigate the effects game on players' motivation.A two-phase approach (calibration exercise phase) applied sample 16 physically active adults. In cardio-exergame "LetterBird," flight pigeon controlled by pedaling rate bike ergometer as input device. During calibration phase heart (HR) responses...
Effective interventions for maltreated children are impeded by gaps in our knowledge of the etiopathogenic mechanisms leading from maltreatment to mental disorders. Although some studies have already identified individual risk factors, there is a lack large-scale multilevel research on how psychosocial, neurobiological, and genetic factors act concert modulate internalizing psychopathology childhood following maltreatment. To help close this gap, we aim delineate gender-specific pathways...
Aberrant subtypes of hepatocellular carcinoma (HCC) account for 20-30% all HCCs and habitually present a challenge in diagnosis treatment. Scirrhous (s-HCC) is often misdiagnosed as cholangiocarcinoma, fibrolamellar carcinoma, or metastasis.Electronic databases (PubMed, Web Knowledge, Google Scholar, Cochrane Library, WHO International Clinical Trials Registry Platform) were searched publications on scirrhous without date language restrictions. Quality assessment was performed using tool...
Ubiquitination and deubiquitylation regulate essential cellular processes involve hundreds of sequentially acting enzymes, many which are barely understood. OTUD3 is an evolutionarily highly conserved deubiquitinase involved in aspects homeostasis. However, its biochemical properties physiological role during development poorly Here, we report on the expression human tissue samples where it appears prominently those neuronal origin. In cells, present cytoplasm can bind to microtubules....
Abstract Aim of this study was to test whether a monoexponential formula is appropriate analyze and predict individual responses the change load bouts online during training. Therefore, 234 heart rate (HR) data sets obtained from extensive interval protocols four participants twelve-week training intervention on bike ergometer were analyzed. First, HR for each approximated using formula. at onset exercise (HR start ), induced by steady ) slope (c) Furthermore, calculation routine...