A5100785339- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Plant responses to water stress
- Veterinary Medicine and Surgery
- Toxoplasma gondii Research Studies
- Glycosylation and Glycoproteins Research
- Microbial infections and disease research
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Plant-Microbe Interactions and Immunity
- Lymphoma Diagnosis and Treatment
- Tracheal and airway disorders
- Milk Quality and Mastitis in Dairy Cows
- COVID-19 Clinical Research Studies
- Diphtheria, Corynebacterium, and Tetanus
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
Massachusetts Institute of Technology
2021-2024
University of Michigan
2024
Michigan State University
2015-2023
Asan Medical Center
2023
National Taiwan University
2011-2016
Chungbuk National University
2014
Feline herpesvirus-1 (FHV-1) is responsible for approximately 50% of diagnosed viral upper respiratory tract disease in cats. The virus infects and replicates the epithelial cells located tract. Commercial vaccines do not protect cats from infection itself or development latency. Previously, our lab developed a cell culture model using primary feline (pFRECs) to study innate immunity FHV-1 deletion mutants. However, numbers pFRECs that can be obtained per cat limited. To improve usage 3D...
Herpesviruses establish a well-adapted balance with their host’s immune system. Despite this co-evolutionary balance, infections can lead to severe disease including neurological disorders in natural host. In horses, equine herpesvirus 1 (EHV-1) causes respiratory disease, abortions, neonatal foal death and myeloencephalopathy (EHM) ~10 % of acute worldwide. Many aspects EHM pathogenesis protection from are still poorly understood. However, it has been shown that the incidence increases...
We sought to study the role of circulating cellular clusters (CCC) -such as leukocyte (CLCs), platelet-leukocyte aggregates (PLA), and platelet-erythrocyte (PEA)- in immunothrombotic state induced by COVID-19. Forty-six blood samples from 37 COVID-19 patients 12 healthy controls were analyzed with imaging flow cytometry. Patients had significantly higher levels PEAs (p value<0.001) PLAs value = 0.015) compared controls. Among patients, CLCs correlated thrombotic complications 0.016),...
Felid herpesvirus-1 (FeHV-1) is an important respiratory and ocular pathogen of cats current vaccines are limited in duration efficacy because they do not prevent infection, viral nasal shedding latency. To address these shortcomings, we have constructed FeHV-1 gE-TK- PK- deletion mutants (gE-TK- PK-) using bacterial artificial chromosome (BAC) mutagenesis shown safety immunogenicity vitro. Here, compare the a prime boost vaccination regimen with commercial cats. Cats groups were vaccinated...
Equine herpesvirus-1 is the cause of respiratory disease, abortion, and equine herpesvirus myeloencephalopathy (EHM) in horses worldwide. EHM affects as many 14% infected a cell-associated viremia thought to be central for pathogenesis. While infrequent younger horses, up 70% aged develop EHM. The aging immune system likely contributes pathogenesis; however, little known about host factors associated with clinical Here, we used “old mare model” induce following EHV-1 infection. Peripheral...
Equine herpesvirus 1 (EHV-1) affects horses worldwide and causes respiratory disease, abortions, equine myeloencephalopathy (EHM). Following infection, a cell-associated viremia is established in the peripheral blood mononuclear cells (PBMCs). This essential for transport of EHV-1 to secondary infection sites where subsequent immunopathology results diseases such as abortion or EHM. Because central role PBMCs pathogenesis, our goal was establish gene expression analysis host genes during...
Dendritic cells (DCs) are professional antigen-presenting that have multiple subpopulations with different phenotypes and immune functions. Previous research demonstrated DCs strong potential for anti-viral defense in the host. However, viruses including alphaherpesvirinae developed strategies to interfere function or maturation of DCs, causing dysfunction avoidance pathogen elimination. The goal present study was isolate characterize equine lung-derived (L-DCs) use studies respiratory...
ABSTRACT Three Corynebacterium mastitidis strains were cultured from the eyes of CD36-knockout mice (B6.129S1- Cd36 tm1Mfe /J) with and without keratitis housed at a biomedical research institute. Bacteria sequenced using Illumina MiSeq technology for subsequent phylogenetic characterization identification virulence factor genes conferring pathogenic potential.
A 12-year-old, female, Eurasian otter (Lutra lutra) reared in Taipei zoo was submitted for necropsy due to sudden death without remarkable clinical history. Parameters of the latest hematology were all within normal limits. At necropsy, there large amounts abdominal effusion, diffuse splenohepatomegaly, generalized lymphadenopathy, consolidation lung, and bilateral enlargement both adrenal glands. Histological examination revealed numbers small medium-sized neoplastic lymphocytes disrupting...
areas; ventricular widths, lengths, and annular diameters of the tricuspid mitral valves.In outflow tract view, aortic pulmonary valves when open closed diameter ascending aorta were measured.In three vessel artery, aorta, superior vena cava, thymus three-vessel tracheal isthmus ductus arteriosus arch proximal distal transverse arches, isthmus, descending measured.The HeartAssist™ (Samsung Medison Co. Ltd., Seoul, Republic Korea) was used for all measurements, which further modified manually...
Lee, Yao; Gallastegi, Ander Dorken; Naar, Leon; Van Cott, Elizabeth; Rosovsky, Rachel; Gregory, David; Annamalai, Damodaran; Kaafarani, Haytham; Velmahos, George; Jarone; Frydman, Galit Author Information