A5091551920- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Veterinary Oncology Research
- Mycotoxins in Agriculture and Food
- Aquaculture disease management and microbiota
- Animal Disease Management and Epidemiology
- Mercury impact and mitigation studies
- Microbial infections and disease research
- Nanoparticles: synthesis and applications
- Marine animal studies overview
- Transgenic Plants and Applications
- Herpesvirus Infections and Treatments
- Animal Nutrition and Physiology
- Virology and Viral Diseases
- Toxin Mechanisms and Immunotoxins
- Drug Transport and Resistance Mechanisms
- T-cell and Retrovirus Studies
- Infectious Diseases and Mycology
- Cell Adhesion Molecules Research
- Pesticide Exposure and Toxicity
- Parasite Biology and Host Interactions
- Nanoparticle-Based Drug Delivery
- Oral and Maxillofacial Pathology
National Taiwan University
2013-2022
National Taiwan University Hospital
2007-2018
Animal Technology Institute Taiwan
1991-2017
Taipei Hospital
2016
Council of Agriculture
2014
Taipei Institute of Pathology
2009-2011
University of Veterinary Medicine
2007
Genomics Research Center, Academia Sinica
2007
Children's Mercy Hospital
1990
University of Missouri–Kansas City
1990
Since 2010, newly identified variants of porcine epidemic diarrhoea virus (PEDV) have caused high mortality in neonatal piglets which has devastated the swine industry. The spike (S) glycoprotein PEDV contains multiple neutralizing epitopes and is a major target for neutralization vaccine development. To understand antigenicity new variant, we characterized genotype 2b isolate from Taiwan, Pintung 52 (PEDV-PT), by generation monoclonal antibodies (NmAbs). Two NmAbs, P4B-1, E10E-1-10 that...
After the last reported cases of rabies in a human 1959 and nonhuman animal 1961, Taiwan was considered free from rabies. However, during 2012-2013, an outbreak occurred among ferret badgers Taiwan. To examine origin this virus strain, we sequenced 3 complete genomes acquired multiple (RABV) nucleoprotein glycoprotein sequences. Phylogeographic analyses demonstrated that RABV affecting (RABV-TWFB) is distinct lineage within group lineages Asia it has been differentiated its closest lineages,...
New variants of porcine epidemic diarrhoea virus (PEDV), which emerged in Taiwan late 2013, have caused a high morbidity and mortality neonatal piglets. To investigate the molecular characteristics spike (S) gene emerging PEDV strains for better understanding genetic diversity relationship among new global PEDVs, full-length S genes PEDVs from nine 1-7 day-old piglets three pig farms central southern were sequenced analysed. The result phylogenetic analysis showed that all closely related to...
Abstract The characteristics of 163 spontaneous neoplasms diagnosed in 150 necropsied zoo mammals, birds, and reptiles at Taipei Zoo during 1994-2003 were analyzed. Histopathology immunohistochemistry employed to classify the tumor types. A total 2657 animals, including 1335 873 birds 449 led diagnosis 8.1% (108/1335), 4.2% (37/873) 1.1% (5/449) cases, respectively. most predominant type tumors mammals was mammary gland (12.0%, 13/108), followed by uterine smooth muscle (10.2%, 11/108),...
A genogroup 2b (G2b) porcine epidemic diarrhea virus (PEDV) Taiwan Pintung 52 (PEDVPT) strain was isolated in 2014. The pathogenicity and host antibody responses elicited by low-passage (passage 5; PEDVPT-P5) high-passage 96; PEDVPT-P96) PEDVPT strains were compared post-weaning PEDV-seronegative pigs oral inoculation. PEDVPT-P5-inoculation induced typical during 1-9 days post inoculation with fecal viral shedding persisting for 26 days. Compared to PEDVPT-P5, PEDVPT-P96 none-to-mild lower,...
In our previous studies using combined radioisotopes with chemotherapeutic liposomal drugs (i.e., <sup>111</sup>In-labeled polyethylene glycol (PEG)ylated vinorelbine) we have reported possible therapeutic efficiency in tumor growth suppression. Nevertheless, the challenge remains as to whether this chemotherapy has a effect good that of combination therapy. The goal study was investigate real effectiveness 6 mol% PEG <sup>111</sup>In-vinorelbine liposomes via elevation radiation dosage and...
Abstract Silver nanoparticles (AgNPs) have been extensively used and are considered as an emerging contaminant in the ocean. The environmental contamination of AgNPs is expected to increase greatly over time, cetaceans, top ocean predators, will suffer negative impacts AgNPs. In present study, we investigate immunotoxicity on leukocytes cetaceans using several methods, including cytomorphology, cytotoxicity, functional activity assays. results reveal that 20 nm Citrate-AgNPs (C-AgNP ) induce...
Abstract The Lapinized Philippines Coronel (LPC) vaccine, an attenuated strain of classical swine fever virus (CSFV), is important tool for the prevention and control CSFV infection widely routinely used in most CSF endemic areas, including Taiwan. aim this study was to investigate whether PCV2 affects efficacy LPC vaccine. Eighteen 6-week-old, cesarean-derived colostrum-deprived (CDCD), crossbred pigs were randomly assigned four groups. A total 10 5.3 TCID 50 experimentally inoculated into...
Myocardial and pancreatic lesions induced by sublethal doses of T-2 toxin in swine were characterized light electron microscopy. Toxin was given intravenously to six 17- 18-week-old pigs. Pigs killed 24 or 48 hours after treatment. Grossly, subendocardial hemorrhages, multifocal pinpoint white foci myocardium, edema occurred one treated pig. Histologic changes myocardium pigs consisted edema, mononuclear cell infiltration, myofiber hyalinization, vacuolation, contraction bands with nuclear...
Thirty-four, 9-to 11-week-old, male castrated, crossbred, specific pathogen-free derived pigs were exposed to a T-2 toxin aerosol at nebulized dose of 0 or 9 mg/kg in pairs, each pair consisting 1 control and treated pig which on the same day. Twenty 30% (1.8 2.7 mg/kg) was retained by pigs. Five pairs killed 1, 3 7 days after dosing. Two designated as 0.33-day group when one died other moribund state 8 10 hours The pulmonary systemic immunity morphologic changes lungs organs examined....