A5055039109- Cancer Genomics and Diagnostics
- Postcolonial and Cultural Literary Studies
- African history and culture studies
- SARS-CoV-2 and COVID-19 Research
- Bioinformatics and Genomic Networks
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- African history and culture analysis
- Linguistic, Cultural, and Literary Studies
- Shakespeare, Adaptation, and Literary Criticism
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- COVID-19 diagnosis using AI
- South Asian Cinema and Culture
- Genomics and Phylogenetic Studies
- Acoustic Wave Phenomena Research
- Health Sciences Research and Education
- Evolution and Genetic Dynamics
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Experimental Learning in Engineering
- Islamic Studies and History
- Network Packet Processing and Optimization
- Microbial Metabolic Engineering and Bioproduction
- Advancements in Semiconductor Devices and Circuit Design
MRC University of Glasgow Centre for Virus Research
2019-2024
Lake Superior State University
2022-2024
IQVIA (United Kingdom)
2022
University of Waterloo
2004-2021
University of Glasgow
2019-2020
Switch
2019-2020
Oslo University Hospital
2020
University of Windsor
2020
Cancer Research UK Scotland Institute
2019
University of the West of Scotland
2019
Abstract The FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines tissues using CAGE. Based on manual curation of sample information development an ontology for classification, we assemble the resulting data into a centralized resource ( http://fantom.gsc.riken.jp/5/ ). This contains web-based tools data-access points research community to search extract related samples, genes, promoter activities, factors enhancers...
Abstract In cancer, the primary tumour’s organ of origin and histopathology are strongest determinants its clinical behaviour, but in 3% cases a patient presents with metastatic tumour no obvious primary. Here, as part ICGC/TCGA Pan-Cancer Analysis Whole Genomes (PCAWG) Consortium , we train deep learning classifier to predict cancer type based on patterns somatic passenger mutations detected whole genome sequencing (WGS) 2606 tumours representing 24 common types produced by PCAWG...
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set become second leading cause of death in our society. The study aim was investigate association between DNA damage response (DDR), replication stress, and novel therapeutic PC develop a biomarker-driven strategy targeting DDR stress PC.
Abstract Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, most cancers outside the sex organs. Efforts to link these clinical specific molecular features focused on somatic mutations within coding regions genome. Here we report a pan-cancer analysis whole genomes 1983 tumours 28 subtypes as part ICGC/TCGA Pan-Cancer Analysis Whole Genomes (PCAWG) Consortium. We both confirm results exome studies, also uncover previously undescribed...
Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classical (pancreatic) and squamous. We find that these are driven by distinct metabolic phenotypes. Loss of genes drive endodermal lineage specification, HNF4A GATA6, switch profiles from predominantly squamous, glycogen synthase kinase 3 beta (GSK3β) a key regulator glycolysis. Pharmacological inhibition GSK3β results in selective sensitivity the squamous subtype;...
COG-UK Mutation Explorer (COG-UK-ME, https://sars2.cvr.gla.ac.uk/cog-uk/-last accessed date 16 March 2022) is a web resource that displays knowledge and analyses on SARS-CoV-2 virus genome mutations variants circulating in the UK, with focus observed amino acid replacements have an antigenic role context of human humoral cellular immune response. This analysis based more than 2 million sequences (as for UK data held CLIMB-COVID centralised environment. COG-UK-ME curates these are...
Ternary content-addressable memories (TCAMs) can perform high-speed and deterministic table lookups. However, its main drawback is high power consumption. A significant portion of the TCAM consumed by match-line sense amplifiers (MLSAs) for match detection. This paper presents a 20-kilobit featuring two MLSAs with positive-feedback techniques. The proposed circuits have been fabricated on test chip in 0.18- mum CMOS technology. Energy measurement results show reductions 56% 48%,...
There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches explain predict their behaviour. Here, we present new, freely available framework includes biologist-friendly language (mEPN), simple but sophisticated method to model parameterisation using information; stochastic flow algorithm simulates the dynamics of activity; 3-D visualisation engine aids understanding complexities system’s dynamics. We example models...
Ternary content addressable memories (TCAMs) are gaining importance in high-speed lookup-intensive applications. However, the high cost and power consumption limiting their popularity versatility. TCAM testing is also time consuming due to complex integration of logic memory. In this paper, we present a comprehensive review design techniques for low-power TCAMs. We propose novel test methodology various components. The proposed algorithms show significant improvement over existing both...
Abstract This paper describes an evidence-based practice of using a hackathon model to address student learning outcomes in first year Engineering programs. There is growing body work around the use hackathons promote engagement, innovation, teamwork, and problem-solving engineers before, during, after their undergraduate studies. Existing tend be open, extra-curricular events with focus on software design UX/UI design. While some have theme steer students towards problem space defined by...
Wastewater-based epidemiology is being used as a tool to monitor the spread of COVID-19 and provide an early warning for presence or increase clinical cases in community. The majority wastewater-based tracking has been utilized sewersheds that service populations tens-to-hundreds thousands. Few studies have conducted assess usefulness wastewater predicting specifically rural areas. This study collected samples from 16 locations across Eastern Upper Peninsula Michigan June December 2021....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to evolve throughout the disease-19 (COVID-19) pandemic, giving rise multiple variants of concern (VOCs) with different biological properties. As pandemic progresses, it will be essential test in near real time potential any new emerging variant cause severe disease. BA.1 (Omicron) was shown attenuated compared previous VOCs like Delta, but is possible that newly may regain a virulent phenotype. Hamsters have been...
This paper proposes a Differential-Input Body Bias Sense Amplifier (DIBBSA) with an auto-offset mitigation feature suitable for low-voltage SRAMs where the differential bitline signals are applied to sources as well body of critical sensing transistors. We simulated and fabricated proposed DIBBSA architecture various operational modes in 65-nm CMOS technology analyze biasing's effectiveness mitigating offset. The standard deviation offset ( σ <sub...
Phononic crystal effects are typically narrowband and highly dependent on the size spacing of scatterers within crystal—properties that fixed unchangeable. We propose it may be possible to dynamically alter behaviour phononic crystals by varying material properties in time. In this paper we seek extend existing static theory so as handle time-varying parameters also provide insight into factors govern their behaviour. Beginning with transmission matrix method, develop a new method determine...
Multiple scattering theory is a versatile two- and three-dimensional method for characterizing the acoustic wave transmission through many scatterers. It provides analytical solutions to propagation in structures, its computational complexity grows logarithmically with number of In this paper we show how 2D can be adapted include effects time-varying material parameters. Specifically, new T-matrix defined frequency modulation that occurs phononic crystals. Solutions were verified against...
<ns4:p>BioLayout <ns4:italic>Express</ns4:italic><ns4:sup>3D</ns4:sup> is a network analysis tool designed for the visualisation and of graphs derived from biological data. It has proved to be powerful in gene expression data, pathways range other applications. In version 3.2 we have introduced ability import, merge display protein interaction networks available BioPAX Level 3 standard exchange format. A graphical interface allows users search or data stored Pathway Commons database. Queries...
Devices based on piezoelectric materials have traditionally been modeled in PDE simulation software. These simulations are expensive to create and run. In this paper it is shown that lumped-parameter models of such devices can provide good fidelity with low computational cost. Modelica supporting components, along a system-level model linear stepper motor presented. The results show agreement published experimental results. Future research proposed the components model.
Sense amplifier (SA) input-referred offset often dictates the minimum required differential input ($\Delta V_{\textrm {BL-min}}$ ) and is an important factor in realizing low-voltage static random access memories. This paper presents a HYbrid latch-type Amplifier (HYSA-QZ), where bitline signals are supplied to multiple internal nodes significantly reduce $\Delta . A 65-nm CMOS test chip with arrays of HYSA-QZ, two intermediate formulations conventional current latch SA (CLSA), voltage...