A5033188496- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Sphingolipid Metabolism and Signaling
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Nail Diseases and Treatments
- Antimicrobial Peptides and Activities
- Spondyloarthritis Studies and Treatments
- Autoimmune Bullous Skin Diseases
- Osteomyelitis and Bone Disorders Research
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Ocular Surface and Contact Lens
- melanin and skin pigmentation
- Eosinophilic Disorders and Syndromes
- Circadian rhythm and melatonin
- Infectious Diseases and Tuberculosis
- Pediatric health and respiratory diseases
University of California, San Diego
2022-2024
Tokyo Medical University
2019-2022
Ehime University
2018-2020
Activation and degranulation of mast cells (MCs) is an essential aspect innate adaptive immunity. Skin MCs, the most exposed to external environment, are at risk quickly degranulating with potentially severe consequences. Here, we define how MCs assume a tolerant phenotype via crosstalk dermal fibroblasts (dFBs) this reduces unnecessary inflammation when in contact beneficial commensal bacteria. We explore interaction human (HMCs) dFBs skin microenvironment test controls MC inflammatory...
Abstract Background Pustulotic arthro‐osteitis (PAO) is a major comorbidity of palmoplantar pustulosis (PPP), which frequently seen in Japanese patients. To determine the characteristics patients with PAO, we conducted multicenter, retrospective epidemiologic survey at four university hospitals. Methods Clinical features including age, gender, duration disease, extrapalmoplantar lesion, smoking habit, focal infection, site joint pain, bone scintigraphy Technetium 99 , and therapies were...
Abstract Palmoplantar pustulosis ( PPP ) and pompholyx are both chronic relapsing diseases occurring on the palms soles. Although these two have been considered completely different from each other, it is sometimes very difficult even for dermatologists to differentiate them other because of their similarities in clinical presentation. In this study, we aimed analyze histopathological features find out “clues” between by features. The histopathology 11 six patients, who were diagnosed with...
The skin microbiome influences pathophysiology. Palmoplantar pustulosis (PPP) is a chronic disease characterized by infectious-like pustules on the palms and soles. These are thought to be sterile because bacterial cultures obtained from negative. However, culture methods limited in their ability identify all bacteria skin. We hypothesized that "sterile" of PPP do not lack bacteria, but rather contain microbiome. To test this hypothesis, we identified using non-culture methods. conducted...
Mast cells (MCs) are tissue-resident immune of a hematopoietic origin that play vital roles in innate and adaptive immunity. Human MCs can be isolated differentiated from various tissue sources, including cord blood, when supplemented with cytokines such as stem cell factor, interleukin 3, 6. Our current research study has shown significant differences the marker expressions human blood-derived mast (hCBMCs) based on donor dependency type medium used for culturing differentiation. These...
Recent studies have identified a subtype of the S1P-receptor family called sphingosine-1-phosphate receptor 2 (S1PR2), which plays crucial role in maintaining skin barrier. It has been observed that S1PR2 and Staphylococcus epidermidis (S. epidermidis) work together to regulate However, interaction between these two factors is still unclear. To investigate this, study was conducted on healthy allergic contact dermatitis (ACD) using 3,4-Dibutoxy-3-cyclobutene-1,2-dione (SADBE) ears S1pr2fl/fl...
Background Psoriasis is an inflammatory skin condition where immune cells play a significant role. The importance of the cross-talk between keratinocytes and in pathogenesis psoriasis has recently been reaffirmed. Recent studies have found that several S1PR functional antagonists, other than S1PR2, are effective improving psoriasis. This study aims to investigate role S1PR2 psoriasis, not investigated before. Methods Spatial transcriptomics, RT-qPCR, flow cytometry were used map cell...