A5049899271- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pregnancy-related medical research
- interferon and immune responses
- RNA modifications and cancer
- RNA Research and Splicing
- Additive Manufacturing Materials and Processes
- Concrete Corrosion and Durability
- Osteoarthritis Treatment and Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Peroxisome Proliferator-Activated Receptors
- Medicinal Plants and Neuroprotection
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Tissue Engineering and Regenerative Medicine
- Healthcare and Venom Research
- Innovative concrete reinforcement materials
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Redox biology and oxidative stress
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Bone Metabolism and Diseases
- Genomics and Phylogenetic Studies
Guangdong Medical College
2020-2024
Guangdong University of Technology
2024
Orthopedic Center
2023
Affiliated Hospital of Guangdong Medical College Hospital
2021
Osteoporosis (OP) is a prevalent metabolic bone disease characterized by loss and structural deterioration, which increases the risk of fracture especially in older people. Recent research has shown that gut microbes play an important role OP. Trimethylamine N-oxide (TMAO), microbiota-derived metabolite, been implicated pathogenesis diseases, including Alzheimer's cerebrovascular disease. This study aimed to examine effect TMAO OP.In this study, we firstly investigated relationship between...
Osteosarcoma (OS) is the most common type of malignant bone tumor that affects children and adolescents.Still, cellular molecular mechanisms driving development this disease remain poorly understood.In study, numerous dysregulated lncRNAs were identified by RNA-seq.As a result, we able to find novel lncRNA Lnc-MAP6-1:3 which highly expressed in osteosarcoma.Using set approaches including gene knockdown, RT-PCR, oncogenic function assay western blotting, observed knockdown expression...
Low back pain (LBP) is a major public health problem worldwide and significant economic burden. Intervertebral disc degeneration (IDD) the reason for LBP. However, we have not identified effective therapeutic strategies to address this challenge. With accumulating knowledge on role of circular RNAs in pathogenesis IDD, realised that (circRNAs) may tremendous potential clinical application prospects field. This review presents an overview current understanding characteristics, classification,...
Osteosarcomas are malignant bone tumors that typically originate in the epiphyses of long bones extremities adolescents. Asiatic acid has been reported to possess anti‑inflammatory, neuroprotective, antidiabetic, antitumor and antimicrobial activities. The present study used a combination network pharmacological prediction <em>in vitro</em> experimental validation explore potential mechanism asiatic against osteosarcoma. A total 78 targets osteosarcoma were identified using databases. Kyoto...
Objective: Most patients with osteosarcoma (OS) have an extremely poor prognosis.The primary purpose of this investigation was to explore the biological effect Lnc-CLSTN2-1:1 on OS and potential processes involved. Materials procedures:We selected differentially overexpressed from our laboratory's existing RNA sequence analysis data (fibroblast osteoblast (hFOB 1.19) three cell lines (HOS, MG63, U2OS) as research object.Next, we detected in HOS line fibroblast cells using qRT-PCR.We...
Objective In this experiment, we screened key miRNAs involved in the dexamethasone-induced decrease osteogenic capacity of mouse precursor osteoblasts MC3T3-E1 over and investigated their specific regulatory mechanisms. Methods cell counting kit assay was utilized to act on cells at 0, 5μM, 10μM, 15μM concentrations dexamethasone for 24h, 48h 72h observe changes viability order select appropriate concentration. Apoptosis reactive oxygen species were detected by flow cytometry. The...
Osteosarcoma is the most common malignant tumor in adolescent bone malignancies. It has characteristics of a high metastasis rate, mortality and poor prognosis. As subclass endogenous noncoding RNAs, circRNAs have been identified to be related occurrence, development prognosis different kinds cancers, but mechanism their effect on osteosarcoma not clear. In present study, we novel circRNA, hsa_circ_0087302, by RNA-seq, found that it was expressed at low levels osteosarcoma. Using RT-PCR,...
OBJECTIVE Nuclear factor erythroid-2 related 2 (Nrf2)/ antioxidant response element (ARE) is a novel defensive pathway involved in the oxidative and chemical stress of cells. The aim study was to explore role Nrf2 on apoptosis human disc nucleus pulpous cells induced by hydrogen peroxide (H2O2). METHODS degeneration model intervertebral established. expression interfered with using sulforaphane (SFN); for that end, three groups were established: blank group (H2O2-/SFN-), control...
Background: Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents, with rapid growth, frequent metastasis, a poor prognosis, but its pathogenesis has not been fully elucidated. Exploring of OS great significance for improving diagnoses finding new therapeutic targets. Methods: Differentially expressed circRNAs (DECs), miRNAs (DEMs), methylated DNA sites (DMSs), mRNAs (DEGs) were identified between control cell lines. GSEA DEGs functional enrichment...
Porous titanium alloy implants with simulated trabecular bone fabricated by 3D printing technology have broad prospects. However, due to the fact that some powder adheres surface of workpiece during manufacturing process, roughness in direct pieces is relatively high. At same time, since internal pores porous structure cannot be polished conventional mechanical polishing, an alternative method needs found. As a technology, plasma polishing especially suitable for parts complex shapes are...
Porous titanium alloy implants with simulated trabecular bone fabricated by 3D printing technology have broad prospects. However, due to the fact that some powder adheres surface of workpiece during manufacturing process, roughness in direct pieces is relatively high. At same time, since internal pores porous structure cannot be polished conventional mechanical polishing, an alternative method needs found. As a technology, plasma polishing especially suitable for parts complex shapes are...