A5091582777- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Malaria Research and Control
- Mosquito-borne diseases and control
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Healthcare Systems and Challenges
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- Complement system in diseases
- Poxvirus research and outbreaks
- Global Health Workforce Issues
- Urinary Tract Infections Management
- Parasites and Host Interactions
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Fecal contamination and water quality
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Vaccine Coverage and Hesitancy
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Ethics in Clinical Research
- COVID-19 epidemiological studies
- Employment and Welfare Studies
MRC Unit the Gambia
2021-2025
London School of Hygiene & Tropical Medicine
2023-2024
National Center for Immunization and Respiratory Diseases
2024
Centers for Disease Control and Prevention
2024
Kenya Medical Research Institute
2015-2023
Microneedle patches (MNPs) have been ranked as the highest global priority innovation for overcoming immunisation barriers in low-income and middle-income countries. This trial aimed to provide first data on tolerability, safety, immunogenicity of a measles rubella vaccine (MRV)-MNP children.
Interrupted time series are increasingly being used to assess the population impact of public health interventions. These data usually correlated over (auto correlated) and this must be accounted for in analysis. Typically, is done using either Prais‐Winsten method, Newey‐West or autoregressive‐moving‐average (ARMA) modeling. In paper, we illustrate these methods via a study pneumococcal vaccine introduction explore their performance under 20 simulated autocorrelation scenarios with sample...
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found NK degranulate and release IFN-γ upon stimulation with antibody-opsonized
Background. Invasive salmonelloses are a major cause of morbidity and mortality in Africa, but the incidence case fatality each disease vary markedly by region. We aimed to describe incidence, clinical characteristics, antimicrobial susceptibility patterns invasive among children adults Kilifi, Kenya.
Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes, but the burden of in low-income and middle-income countries is dominated pneumonia, most which non-bacteraemic. We examined effect 10-valent PCV on incidence pneumonia Kenya.
Health workers' strikes are a global occurrence. Kenya has had several by health workers in recent years but their effect on mortality is unknown. We assessed the of six that occurred from 2010 to 2016 Kilifi, Kenya. Using daily data obtained Kilifi and Demographic Surveillance System, we fitted negative binomial regression model estimate change during strike periods 2 weeks immediately after strikes. did subgroup analyses age, cause death, week. Between Jan 1, 2010, Nov 30, 2016, recorded 1...
Infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) among hospitalized neonates in sub-Saharan Africa pose significant clinical challenges. Data on prevalence and acquisition of ESBL-E carriage the region are few, risk factors for transmission not clearly defined.In a cohort study consecutive neonatal admissions to Kilifi County Hospital from July 2013 through August 2014, we estimated admission using rectal swab cultures identified logistic regression....
Abstract Background Human infection studies (HIS) that involve deliberately infecting healthy volunteers with a pathogen raise important ethical issues, including the need to ensure benefits and burdens are understood appropriately accounted for. Building on earlier work, we embedded social science research within an ongoing malaria human study in coastal Kenya understand experienced by stakeholders this low-resource setting assess wider implications for future planning policy. Methods Data...
Abstract Background Vector control interventions in sub-Saharan Africa rely on insecticide-treated nets and indoor residual spraying. Insecticide resistance, poor coverage of interventions, quality changes vector behavior threaten the effectiveness these and, consequently, alternative tools are needed. Mosquitoes die after feeding humans or animals treated with ivermectin (IVM). Mass drug administration (MDA) IVM could reduce survival decrease malaria transmission. The entomological impact...
Radiologically-confirmed pneumonia (RCP) is a specific end-point used in trials of Pneumococcal Conjugate Vaccine (PCV) to estimate vaccine efficacy. However, chest radiograph (CXR) interpretation varies within and between readers. We measured the repeatability reliability paediatric CXR using percent agreement Cohen's Kappa validity field readings against expert review study impact PCV on pneumonia.CXRs were obtained from 2716 children admitted 2006 2014 Kilifi County Hospital, Kilifi,...
Abstract Background Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes but the burden of in developing countries is dominated pneumonia, most which non-bacteraemic. We examined impact PCV on pneumonia incidence. Methods linked prospective hospital surveillance for clinically-defined WHO severe or very-severe at Kilifi County Hospital from 2002-2015 to population Health and Demographic Surveillance System, comprising...
Abstract Malaria caused by Plasmodium spp . leads to significant morbidity and mortality, particularly in Sub-Saharan African countries with falciparum being the predominant infectious species. The pathogenesis of P. depends on multiple host parasitic factors, one which is evasion immune response due antigenic variability during blood stage infection. understudied infected erythrocyte expressed protein families STEVOR RIFIN characterize hypervariability are associated clinical outcome...