A5101846747- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Cryospheric studies and observations
- Spectroscopy Techniques in Biomedical and Chemical Research
- Colorectal Cancer Surgical Treatments
- Advanced biosensing and bioanalysis techniques
- Climate variability and models
- Sepsis Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Carbon and Quantum Dots Applications
- Phagocytosis and Immune Regulation
- TGF-β signaling in diseases
- Sympathectomy and Hyperhidrosis Treatments
- Soil Moisture and Remote Sensing
- Anorectal Disease Treatments and Outcomes
- Hemostasis and retained surgical items
- Lymphatic System and Diseases
- Infectious Diseases and Mycology
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Escherichia coli research studies
- Electrolyte and hormonal disorders
- Neurological Disease Mechanisms and Treatments
- Genetic and Kidney Cyst Diseases
- Gut microbiota and health
Jiangsu Normal University
2017-2023
Shandong University
2014-2023
Shenzhen Pingle Orthopedic Hospital
2022
Xi'an Jiaotong University
2021
Fuyang Second People's Hospital
2021
Anhui Science and Technology University
2021
Weatherford College
2021
Affiliated Hospital of Jiangsu University
2021
Jiangsu University
2021
Nanjing Medical University
2021
Tong-fu-li-fei (TFL) prescription has already used to treat sepsis in clinic but its mechanism remains unclear. Here, we aimed investigate the effect and of on rats. The Sprague–Dawley rats were divided into sham group, model TFL 3.6 g/kg 7.2 g/kg-treated group. was induced by cecal ligation puncture (CLP). After 7 days, treatment improved survival rate CLP alleviated sepsis-induced intestinal mucosal injury. ELISA assay showed that inflammatory cytokine expressions including TNF-α IL-1β...
Recent studies have shown that programmed cell death 4 (PDCD4) modulates distinct signal transduction pathways in different pathological conditions. Despite acute and chronic immune responses elicited by ischemia contributing to the functional deterioration of kidney, contributions mechanisms PDCD4 kidney injury (AKI) remained unclear. Using two murine AKI models including renal ischemia/reperfusion (IRI) cisplatin-induced AKI, we found deficiency markedly ameliorated dysfunction...
The ability to produce high-resolution climate maps is crucial for assessing change impacts and mitigating disasters risks in developing countries. Mainstream geostatistical downscaling techniques use spatial interpolation or multi-linear regression models data-scarce regions. Since global evolution a nonlinear process governed by complex physical principles, these linear cannot achieve the desired accuracy. Moreover, utilize different resolution data as model inputs. In this study, we...
Previous studies have found that children with multiple exposures to anesthesia at an early age are increased risk of learning and memory impairment.Sevoflurane is the most commonly used inhalational anesthetic for general in children.Multiple sevoflurane been shown induce neuroinflammation, inhibit neurogenesis, cause subsequent impairments fetal mice.Histone-tail acetylation has implicated formation.In this study, we employed suberanilohydroxamic acid (SAHA), inhibitor histone...
A novel means for half-life extension of peptide drugs.<bold>3d</bold>has potential to be developed as a therapeutic agent T2DM.
We here reported 2 novel Xenopus glucagon-like peptide-1 (xGLP-1) analogs, xGLP159 and xGLP296, whose therapeutic effects on metabolic efficacy glycemie control were evaluated in rodents. The vitro potency of xGLP296 investigated human embryonic kidney 293 cells. acute glucose-lowering insulinotropic assessed the Institute Cancer Research, Kunming, diabetic (db/db) mice. pharmacokinetic profiles confirmed Sprague-Dawley (SD) rats their long-acting hypoglycemic anorectic db/db Chronic...
To assess the value of application percutaneous radiofrequency ablation (RFA) with artificial hydrothorax for liver cancer in hepatic dome.Thirty-two patients 43 lesions malignant tumors dome underwent ultrasound-guided hydrothorax. Artificial was created by infusion saline via an intrathoracically placed 14-G central venous catheter, which percutaneously inserted before RFA, separating right lung from dome. The adverse reaction and therapeutic efficacy were also analyzed.In 32 (4 segment IV...
Dimerization is a useful tool to boost ligand-receptor interaction. Both lipidation and dimerization effectively prolong the short half-life (t 1/2) of peptides by facilitating binding with serum albumin increasing hydrodynamic size. Here, we described two novel GLP-1 conjugates high glucagon-like peptide-1 (GLP-1) receptor activation potencies, dimerized (Di-GLP-1) lipidated Di-GLP-1 (Lip-Di-GLP-1). Lip-Di-GLP-1 were prepared through cysteine-maleimide specific coupling reactions using...
Antibiotics are the cornerstone to cure infectious diseases, however, it also destroys intestinal inherent microflora, and may cause serious gastrointestinal dysfunction, such as abdominal distension, diarrhea, mucosal barrier damage etc. In severe conditions, induce sepsis. With development of human microbiology group program popularity microbial sequencing technology, people can comprehend effects antibiotics on flora deeply, meanwhile traditional biomedical model (the basis bacterial...
Background. Long noncoding RNAs (lncRNAs) represent an important novel class of RNA molecule greater than 200 nucleotides that play a key role in the regulation autoimmune diseases. Previous studies have demonstrated MAFTRR (MAF transcriptional regulator RNA) regulated Th1 cells differentiation by inhibiting expression MAF activated CD4+ T cells. However, effect on pathogenesis Hashimoto’s thyroiditis (HT) remains unclear. This research was aimed at investigating as well correlation between...
This report presents a contactless and robust dielectric microspheres (DMs)-assisted surface enhanced Raman scattering (SERS) enhancement method to improve SERS detection sensitivity sensitivity. DMs that could focus collect light were embedded within the polydimethylsiloxane (PDMS) film avoid direct contact with analytical solution reliability. The as prepared PDMS (DMs-PDMS) was integrated microfluidic technique enhance signal of liquid substrate. Detection in systems can reduce reagent...
Aim: Lymphaticovenular anastomosis (LVA) is the mainstay of surgical treatment lymphedema now. Indocyanine green (ICG) lymphography a method for detecting lymphatic pathways and clinical evaluation patients with extremity lymphedema. The essential point LVA to find more functional vessels. Sometimes, in cases dysfunction, ICG injections into distal extremities are insufficient. purpose this study was elucidate effect multi-injection on LVA.
Acute heart failure (HF) is a common cause of hospital admission. This study aims to compare continuous infusion and intermittent boluses furosemide in treating acute HF.This protocol systematic review meta-analysis has been drafted under the guidance preferred reporting items for reviews meta-analyses protocols. Electronic databases including Web Science, Embase, PubMed, Wanfang, Data, Scopus, Science Direct, Cochrane Library will be searched June 2021 by 2 independent reviewers. The main...
MicroRNA could participate in a variety of physiological and pathological processes via identifying the target genes by their seed sequences regulating gene expression at post-transcriptional level.Glomerular mesangial cell is one most chief cells glomerulus plays an important role renal fibrosis.The cellular proliferation dysfunction may appear once attacked pathogenic factors.Then, extracellular matrix increases stimulation inflammatory cytokines, eventually, resulting glomerular sclerosis...
Sparse and irregular climate observations in many developing countries are not enough to satisfy the need of assessing change risks planning suitable mitigation strategies. The wide-used statistical downscaling model (SDSM) software tools use multi-linear regression extract linear relations between large-scale local variables then produce high-resolution maps from sparse observations. latest machine learning techniques (e.g. SRCNN, SRGAN) can nonlinear links, but they only for low-resolution...
Antibiotic resistance genes (ARGs) in the environment have gradually engendered extensive concern recently due to harm caused and human beings. In this study, two sulfonamides resistant bacteria isolated from secondary effluents of a municipal wastewater treatment plant were used compare efficacy three different disinfection processes (chlorination, ultraviolet ozone) reducing pollution using serial dilution plate counting method qPCR. The behavior characteristics during process elucidated...