A5042003692- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Kawasaki Disease and Coronary Complications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Coronary Artery Anomalies
- Immune Cell Function and Interaction
- Plant Pathogens and Fungal Diseases
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- Vitamin D Research Studies
- Child and Adolescent Psychosocial and Emotional Development
- Nail Diseases and Treatments
- Resilience and Mental Health
- Urticaria and Related Conditions
- Mast cells and histamine
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- Mental Health Treatment and Access
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
- Workplace Spirituality and Leadership
- Hemophilia Treatment and Research
Post Graduate Institute of Medical Education and Research
2016-2025
Institute of Post Graduate Medical Education and Research
2023
ABSTRACT In recent years, the well-known plant pathogens of Colletotrichum genus were increasingly reported to cause ophthalmic infections in humans. Among 66 species genus, only a few are known be pathogenic for We report here five cases due truncatum , never earlier human infection. The isolates identified by morphological characteristics and sequencing internal spacer regions ribosomal DNA. progress lesions those patients was slow compared that caused Aspergillus or Fusarium infections....
Kawasaki disease (KD) is a common systemic vasculitis of childhood. Although it has been almost 6 decades since Dr. Tomisaku reported the first case series KD, underlying cause remains mystery. KD self-limiting disease. However, dreaded complication development coronary artery abnormalities (CAAs). most acquired heart in children developed world and being increasingly from developing countries too. Over years, significant observations have made about epidemiology KD. It usually affects below...
Management of Candida auris infection is difficult as this yeast exhibits resistance to different classes antifungals, necessitating the development new antifungals. The aim study was investigate susceptibility C. a novel antifungal triazole, PC945, optimized for topical delivery.A collection 50 clinical isolates obtained from tertiary care hospital in North India. Nine UK, 10 CDC panel (USA) and 3 CBS-KNAW culture (Japanese South Korean isolates) were also obtained. MICs (azole endpoint)...
Introduction. Histopathological examination (HPE) of tissue helps in the diagnosis invasive fungal infections (IFIs) but cannot identify fungus to genus/species level Gap Statement Available protocols for molecular identification fungi from formalin-fixed and paraffin-embedded (FFPE) tissues have limitations terms extraction target selection, standardisation. Aim. Development sequence-based protocol after DNA tissues. Methodology. A total 63 FFPE histopathology proven IFI cases were used...
ABSTRACT Invasive aspergillosis (IA) due to Aspergillus flavus is associated with high mortality. Although voriconazole (VRC) widely recommended as the first-line treatment for IA, emergence of azole resistance in spp. translating failure. We evaluated efficacy a nonneutropenic murine model disseminated A. infection using two voriconazole-resistant isolates (one harboring Y319H substitution cyp51C gene) and wild-type without mutations. All exhibited dose-response relationship, improved mouse...
The magnitude of azole resistance in
Hereditary angioedema (HAE) is characterized by unpredictable acute attacks that impair the patient's quality of life (QoL) not only due to impact on functional abilities caused edema but also pain and other symptoms, including fatigue, nausea, vomiting. QoL studies in patients with HAE have been carried out Indian subcontinent. Hence, we this study assess identify factors associated impaired HAE. This was a cross-sectional observational confirmed cases HAE, aged >18 years, using score...
Kawasaki disease (KD) is an acute childhood vasculitis, commonly seen in children under the age of five. Despite extensive research over past five decades, pathogenesis KD remains elusive. The objective this epigenetic reanalysis study to delineate common pathways involved using a bioinformatics approach. Array datasets from Gene Expression Omnibus repository were extracted and subjected analysis Chip Analysis Methylation Pipeline R statistical tool for identification differential...
Seborrhoeic dermatitis/dandruff (SD/D) is a common, persistent, relapsing inflammatory condition affecting the areas rich in sebaceous glands. SD/D widely prevalent India but Malassezia species implicated are not well studied. To estimate prevalence and spectrum of causing understand sociodemographic characteristics rural urban populations, total 200 patients 100 healthy controls (HC) from both backgrounds were enrolled this study. severity was clinically graded as mild, moderate, severe,...
Hereditary angio-oedema (HAE) is a rare autosomal dominant disorder characterized clinically by recurrent episodes of nonpruritic subcutaneous and/or submucosal oedema. Laryngeal oedema the commonest cause mortality in patients with HAE. Prior to availability first-line treatment options for management HAE, was as high 30%. Mortality has significantly declined countries where are available and can access these therapies. There paucity literature on outcomes HAE developing still challenge.
<b><i>Introduction:</i></b> X-linked lymphoproliferative syndrome (XLP) is a rare primary immune deficiency. Two types of XLP have been described: XLP-1 and XLP-2. <b><i>Methods:</i></b> We found 7 patients with (3 had 4 XLP-2) after reviewing the data from Pediatric Immunodeficiency Clinic 1997 to 2021. <b><i>Results:</i></b> Mean age at diagnosis was 3.8 years, mean delay in 2.6 years. Five recurrent episodes...