A5087669571- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- COVID-19 epidemiological studies
- COVID-19 and healthcare impacts
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Climate Change and Health Impacts
- Hepatitis B Virus Studies
- Polyamine Metabolism and Applications
- Rabies epidemiology and control
- Viral Infections and Vectors
- Cardiac Arrest and Resuscitation
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Acute Lymphoblastic Leukemia research
- Otolaryngology and Infectious Diseases
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Antibiotics Pharmacokinetics and Efficacy
- Retinoids in leukemia and cellular processes
- COVID-19 impact on air quality
- Antimicrobial Resistance in Staphylococcus
University of Chicago
2014-2024
Boston University
2023-2024
Virginia Commonwealth University
2018-2023
University Health System
2019-2023
Cincinnati Children's Hospital Medical Center
1993
University of Cincinnati
1993
Roswell Park Comprehensive Cancer Center
1990
We studied sources of variation between countries in per-capita mortality from COVID-19 (caused by the SARS-CoV-2 virus). Potential predictors coronavirus-related 200 May 9, 2020 were examined, including age, gender, obesity prevalence, temperature, urbanization, smoking, duration outbreak, lockdowns, viral testing, contact-tracing policies, and public mask-wearing norms policies. Multivariable linear regression analysis was performed. In univariate analysis, prevalence gross domestic...
Objectives: Rapid fluid resuscitation has become standard in sepsis care, despite “low-quality” evidence and absence of guidelines for populations “at risk” volume overload. Our objectives include as follows: 1) identify predictors reaching a 30 mL/kg crystalloid bolus within 3 hours onset (30by3); 2) assess the impact 30by3 dosing on clinical outcomes; 3) examine differences perceived “at-risk” volume-sensitive populations, including end-stage renal disease, heart failure, obesity, advanced...
ABSTRACT. We studied all-cause mortality during the COVID-19 pandemic in 19 Indian states (population 1.27 billion). Excess was calculated by comparison with years 2015 to 2019. The known deaths reported for a state were assumed be accurate, unless excess data suggested higher toll. Data from one excluded due anomalies. In several regions, fewer 2020 than expected. Areas Andhra Pradesh, Delhi, Haryana, Karnataka, Madhya Tamil Nadu, and West Bengal saw spikes Spring 2021. pandemic-related...
Abstract Toxoplasma gondii , the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. forms cysts in vitro that induce oocysts cats, gold standard criterion for cysts. These highly express cytochrome b . Using these models, envisioned, then created, 4-(1 H )-quinolone scaffolds target...
Toxoplasma gondii infection causes substantial morbidity and mortality in the United States, infects approximately one-third of persons globally. Clinical manifestations vary. Seropositivity is associated with neurologic diseases malignancies. There are few objective data concerning US incidence distribution toxoplasmosis.
Background Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed treated outcomes improved. Methods We tested 180 sera with the Toxoplasma ICT IgG-IgM point-of-care (POC) test. Sera were from 116 chronically infected persons (48 serotype II; 14 I-III; 25 I-IIIa; 28 Atypical, haplogroup 12; 1 not typed). These represent strains parasites...
We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid in a stable [GLA-SE]) for their ability to protect against Toxoplasma gondii HLA transgenic mice. Our constructs each included 5 of our best down-selected CD8+ T cell–eliciting epitopes, universal CD4+ helper lymphocyte epitope (PADRE), secretory signal, all arranged optimal MHC-I presentation. Their capacity elicit immune protective responses was studied using...
Background Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, substantial costs worldwide. Objectives We asked whether high performance an Immunochromatographic-test (ICT) could enable accurate, rapid diagnosis/treatment, establishing new, improved care-paradigms at point-of-care clinical laboratory. Methods Data were obtained in 12 studies/analyses addressing: 1-feasibility/efficacy;...
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative other cytochromeb inhibitors, JAG21 has solubility ADMET properties, without need for pro-drug. significantly reduces Toxoplasma gondii tachyzoites encysted bradyzoites in vitro, primary established chronic vivo....
Abstract Fighting smart diseases requires vaccines. Novel ways to present protective immunogenic peptide epitopes human immune systems are needed. Herein, we focus on Self Assembling Protein Nanoparticles (SAPNs) as scaffolds/platforms for vaccine delivery that produce strong responses against Toxoplasma gondii in HLA supermotif, transgenic mice. a useful platform peptides elicit CD4 + , CD8 T and B cell core architecture, formed by flagellin, administered combination with TLR4...
Hydrocephalus occurs in children with congenital toxoplasmosis and can lead to severe disability. In these cases, the decision intervene is often influenced by expectation of neurological recovery. this study, clinical responses neurosurgical intervention hydrocephalus secondary are characterized.
Twenty-two compounds belonging to several classes of polyamine analogues have been examined for their ability inhibit the growth human malaria parasite Plasmodium falciparum in vitro and vivo. Four lead from sub-series thiourea one compound urea-based were found be potent inhibitors both chloroquine-resistant (Dd2) chloroquine-sensitive (3D7) strains with IC50 values ranging 150-460 nM. In addition, RHW, N1, N7-bis (3-(cyclohexylmethylamino) propyl) heptane-1,7-diamine tetrabromide was Dd2...
Point-of-care (POC) testing for Toxoplasma infection has the potential to revolutionize diagnosis and management of toxoplasmosis, especially in high-risk populations areas with significant environmental contamination poor health infrastructure precluding appropriate follow-up preventing access medical care. Toxoplasmosis is a public challenge Morocco, relatively heavy burden and, this point, minimal investment nationally address infection. Herein, we analyse performance novel, low-cost...
Abstract As both testing for SARS Cov-2 and death registrations are incomplete or not yet available in many countries, the full impact of Covid-19 pandemic is currently unknown world regions. We studied all-cause mortality 19 Indian states (combined population 1.27 billion) with data during entire state large cities. Excess was calculated by comparison from years 2015-2019. The known deaths reported Johns Hopkins University Center Systems Science Engineering a were assumed to be accurate,...
Abstract Purpose To determine sources of variation between countries in per-capita mortality from COVID-19 (caused by the SARS-CoV-2 virus). Methods Potential predictors coronavirus-related 200 May 9, 2020 were examined, including age, sex, obesity prevalence, temperature, urbanization, smoking, duration infection, lockdowns, viral testing, contact tracing policies, and public mask-wearing norms policies. Multivariable linear regression analysis was performed. Results In univariate analyses,...
Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we used Tropical Disease Research database, crystallography, molecular modeling, antisense to identify characterize a range of potential therapeutic targets toxoplasmosis. Phosphoglycerate mutase II (PGMII), nucleoside diphosphate kinase (NDK),...
Abstract Purpose of Review work to create and evaluate educational materials that could serve as a primary prevention strategy help both providers patients in Panama, Colombia, the USA reduce disease burden Toxoplasma infections. Recent Findings Educational programs had not been evaluated for efficacy USA, or Colombia. Summary high school students, pregnant women, medical students professionals, scientists, lay personnel were created. In most settings, short-term effects evaluated. all...
The dose and timing of early fluid resuscitation in sepsis remains a debated topic. objective this study is to evaluate the effect management on mortality other clinical outcomes.Single-center, retrospective cohort emergency-department-treated adults (>18 years, n = 1032) presenting with severe or septic shock. Logistic regression evaluating impact 30 mL/kg crystalloids mortality-versus-time plot controlling for emergency department score, lactate, antibiotic timing, obesity, sex, systemic...