A5000904692- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Bone Tissue Engineering Materials
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Cancer Treatment and Pharmacology
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Natural Compounds in Disease Treatment
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Quinazolinone synthesis and applications
- Lipid metabolism and disorders
- Pediatric health and respiratory diseases
- Immune cells in cancer
- Bone Metabolism and Diseases
- Melanoma and MAPK Pathways
- Enzyme Structure and Function
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Pituitary Gland Disorders and Treatments
Second Affiliated Hospital of Harbin Medical University
2023-2024
Harbin Medical University
2023-2024
The University of Texas MD Anderson Cancer Center
2001-2020
University of Mississippi Medical Center
2013
Saitama Medical University
2013
Massachusetts General Hospital
2013
Queen Elizabeth II Medical Centre
2003
Periodontitis is a complex, multifactorial process affected by bacterial plaque-components and host defense mechanisms. Inflammation of the periodontitium may lead destruction underlying ligament alveolar bone. Receptor activator NF-kappaB ligand (RANKL), novel TNF receptor-related protein an important factor for osteoclast differentiation activation. Given osteolysis has been demonstrated in periodontitis, we hypothesized that RANKL expression be associated with bone periodontitis. We used...
Background: Lung cancer risk remains elevated for many years after quitting smoking. To assess using proliferation indices in bronchial tissues as an intermediate endpoint biomarker lung chemoprevention trials, we determined the relationship between extent, intensity, and cessation of tobacco smoking proliferative changes epithelial biopsy specimens. Methods: Bronchial specimens were obtained from up to six sites 120 current smokers (median pack-years, 42) 207 former 40; median quit-years,...
OBJECTIVE: Glioblastoma multiforme is the most frequent primary brain tumor in adults. The major obstacle for successful treatment invasive growth pattern. Metabolically, glioblastomas are highly glycolytic, leading to increased levels of lactic acid production. carbonic anhydrase IX (CAIX) moderates extrusion hydrogen ions into extracellular space, which may enhance invasion by activating proteolytic enzymes. We therefore induced glycolysis glioblastoma cells and investigated pH, cathepsin...
Gangliogliomas (GGs) represent <1% of primary brain tumors in adults. Little is known regarding prognostic features, clinical characteristics, or the impact treatment on patient outcomes.Our neuro-oncology longitudinal database was screened for patients with GG from 1992 to 2012. Sixty-seven (age >18 y) were identified.Sixty-two presented low-grade and 5 anaplastic GG. The median age at diagnosis 29 years. With a follow-up 4.7 years after initial diagnosis, 23 had progressive disease. Range...
Abstract Spinal cord injuries (SCIs) often result in secondary damage; therefore, interventions beyond current cell transplantation methods must be explored. The innate phagocytic propensity of macrophages are exploited for artificially aged erythrocytes and developed a delivery system fusing with reactive oxygen species (ROS)‐reactive nanoparticles prepared from diselenide‐bond cross‐linked organic compound. targets peripheral blood macrophages, delivering anti‐glutamate drug‐loaded to the...
In this study, a new-generation tissue-engineered bone capable of temporally regulating the immune response, balancing proinflammatory and anti-inflammatory activities, facilitating regeneration repair to address challenges delayed healing nonunion in large-sized defects, is innovatively developed. Using innovative techniques including multiphysics-assisted combined decellularization, side-chain biochemical modification, sterile freeze-drying, novel photocurable extracellular matrix...
BACKGROUND: The treatment of patients with primary CNS lymphomas (PCNSL) has dramatically changed since the 1970's when whole brain radiation generated median survivals about 12 months, significant neurotoxcity, and few long term survivors.High dose methotrexate (HD-MTX) monotherapy without provides excellent response rates 30% survivors neurotoxicity.In general, relapses occur in first two to four years after diagnosis reports very late are rare.METHODS: Charts all treated HD-MTX for newly...
BACKGROUND: Ganglioglioma (GG) are rare mixed glial-neuronal neoplasms of the central nervous system. METHODS: Retrospective review 57 patients below 21 years diagnosed with GG at MD Anderson Cancer Center, Houston from 1992 to 2012 was performed. Patient demographics, clinical history, radiological features and treatment data were collected analyzed. Kaplan-Meier Cox-regression analysis used assess disease progression free survival (PFS) symptom (SFS) time after surgery. RESULTS: Median...