A5101734347- Wound Healing and Treatments
- Sodium Intake and Health
- Sleep and Wakefulness Research
- Blood Pressure and Hypertension Studies
- Pain Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Cancer, Lipids, and Metabolism
- Neonatal Health and Biochemistry
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related molecular mechanisms research
- Stroke Rehabilitation and Recovery
- Neuroscience and Neuropharmacology Research
- Balance, Gait, and Falls Prevention
- Sympathectomy and Hyperhidrosis Treatments
- High Altitude and Hypoxia
- Renal function and acid-base balance
- Heme Oxygenase-1 and Carbon Monoxide
- Pain Management and Treatment
- Bone Tissue Engineering Materials
- Traumatic Brain Injury Research
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal Cancer Surgical Treatments
- Nanoparticle-Based Drug Delivery
- Anesthesia and Neurotoxicity Research
- Anorectal Disease Treatments and Outcomes
Harbin Medical University
2020-2025
First Affiliated Hospital of Harbin Medical University
2024-2025
Fourth Affiliated Hospital of Harbin Medical University
2020-2025
Nanjing Medical University
2025
China Medical University
2019-2024
Capital Medical University
2023-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
The George Institute for Global Health
2020-2024
UNSW Sydney
2020-2024
Salt substitutes with reduced sodium levels and increased potassium have been shown to lower blood pressure, but their effects on cardiovascular safety outcomes are uncertain.
Abstract The regenerative treatment of infectious vertical bone defects remains difficult and challenging today. Current clinical treatments are limited in their ability to control bacteria infection, which is unfavorable for new formation calls a type material with excellent osteogenic antibacterial properties. Here multifunctional scaffold synthesized that mimics natural nanostructures by incorporating silver nanowires into hierarchical, intrafibrillar mineralized collagen matrix...
Diabetic foot ulcers (DFUs) are a threat to human health and can lead amputation even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found be beneficial for diabetic healing. As we demonstrated previously, polylactide-polyglycolide (PLGA) cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility facilitate fibroblast adhesion, spreading proliferation. PLGA/CNC novel materials that have not been used previously as NT carriers...
To compare the GABA+/Glx (glutamate-glutamine) ratio in prefrontal lobe under non-rapid eye movement sleep between patients with narcolepsy type 1 (NT1) and normal controls explore correlation this difference abnormal cognitive function, using synchronous electroencephalography-functional magnetic resonance spectroscopy (EEG-fMRS).
BACKGROUND:Cisplatin (cis-diamminedichloroplatinum, DDP) resistance is identified as the primary obstacle during lung cancer treatment, while DDP exist extensively. This report was to investigate roles of propofol in cells tolerance and potential mechanisms. MATERIAL AND METHODS:A549 A549/DDP were treated with for 48 hours, cell proliferation suppression rate detected by MTT (thiazolyl blue tetrazolium bromide) assay half maximal inhibitory concentration (IC₅₀) calculated. Besides, apoptosis...
Abstract The application of network formulaology and pharmacology has significantly advanced the scientific understanding traditional Chinese medicine (TCM) treatment mechanisms in disease. field herbal biology is experiencing a surge data generation. However, researchers are encountering challenges due to fragmented nature reliance on programming tools for analysis. We have developed TCMNPAS, comprehensive analysis platform that integrates formularology pharmacology. This designed...
Abstract Spinal cord injuries (SCIs) often result in secondary damage; therefore, interventions beyond current cell transplantation methods must be explored. The innate phagocytic propensity of macrophages are exploited for artificially aged erythrocytes and developed a delivery system fusing with reactive oxygen species (ROS)‐reactive nanoparticles prepared from diselenide‐bond cross‐linked organic compound. targets peripheral blood macrophages, delivering anti‐glutamate drug‐loaded to the...
There is an association between increased dietary sodium intake and the risk of stomach cancer. Lowering with sodium-reduced potassium-enriched salt substitutes may reduce this risk. To evaluate effects on cancer other types The primary analyses Salt Substitute Stroke Study (SSaSS) defined compared to regular stroke. This post-hoc investigation explored cancers. SSaSS was open-label, cluster randomised controlled trial done in 600 Chinese villages among 20,996 participants. Villages were...
Abstract Spinal cord injury (SCI) is a complex and dynamic pathological condition characterized by disrupted lipid metabolism neuroinflammatory responses, posing significant therapeutic challenges. To address these, biomimetic bacterial outer membrane nanoparticles (BM‐NPs) are designed integrating the precise targeting capability of detoxified vesicles (dOMVs) with efficient drug‐loading properties liposomes. BM‐NPs exhibit superior efficiency toward peripheral neutrophils macrophages,...
Abstract Metabolic reprogramming is a hallmark of neutrophil activation in sepsis. LncRNAs play important roles manipulating cell metabolism; however, their specific involvement sepsis remains unclear. Here we found that 11 lncRNAs and 105 mRNAs were differentially expressed three transcriptome datasets (GSE13904, GSE28750, GSE64457) gene expression blood leukocytes neutrophils septic patients healthy volunteers. After Gene Ontology biological process analysis lncRNA–mRNA pathway network...
Abstract Diabetic foot ulcers (DFUs) are a constant threat to diabetic patients and can lead amputations even death. Intralesional administration of propranolol in wounds has not been reported previously. This study aimed investigate the efficacy cream wounds. Fifty‐six spontaneously mice were divided into group control group. After preparing full‐thickness on back mice, 1% was topically applied experimental 0% controls. The wound sizes measured calculated against original area. analyzed up...
The purpose of the present study was to investigate effect carbon monoxide (CO) released from CO‑releasing molecule 2 (CORM‑2) on mice with acute pancreatitis (AP). To perform investigation, a mouse AP model established using caerulein. were treated or without CORM‑2. survival rate in different groups analyzed, and serum amylase lipase levels measured assess degree pancreatic injury. severity also evaluated by histological examination, histopathological scoring damage performed. Pancreatic...
Psychological factors and stress can cause hair loss. The sympathetic-adrenal-medullary (SAM) axis has been reported to regulate the growth of follicles (HF). sympathetic nerve is a component SAM axis, but it not sufficiently or convincingly linked growth. In this study, we demonstrate that chemical sympathectomy via administration neurotoxin 6-hydroxydopamine (6-OHDA) mice inhibited HF growth, treatment with β-adrenoceptor antagonist propranolol (PR) had no effect. length skin thickness...
Zinc finger and BTB domain containing 7A (ZBTB7), a POZ/BTB Krüppel erythroid myeloid oncogenic factor, is critical for the tumorigenicity progression of various cancer types. ZBTB7 has been reported to promote cell proliferation colorectal cancers (CRC). However, function 5-fluorouracil (5‑FU) resistance not yet studied. In current study, expression in 5‑FU CRC were investigated using with multidisciplinary approaches, including western blot analysis, Transwell assay, CCK8 tumor xenograft...
Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) nondiabetic wounds, but 6-OHDA diabetic wounds have not been previously reported. In this study, treated mice received intraperitoneal 6-OHDA, and control injections normal saline. Full-thickness were established backs mice. The sectioned (four per group) for analysis at 2, 5, 7, 10, 14, 17, 21 days after injury. wound areas in group larger than those treatment group. Histological scores...