A5082152082- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Transplantation: Methods and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Urologic and reproductive health conditions
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
- Tumors and Oncological Cases
- PI3K/AKT/mTOR signaling in cancer
- Organ Transplantation Techniques and Outcomes
- Congenital Heart Disease Studies
- Caveolin-1 and cellular processes
Texas Children's Hospital
2017-2025
Baylor College of Medicine
2008-2024
The University of Texas MD Anderson Cancer Center
2010-2016
Molecular Oncology (United States)
2016
We undertook this study to understand how the transcription factor Sox2 contributes malignant phenotype of glioblastoma multiforme (GBM), most aggressive primary brain tumor. initially looked for unbalanced genomic rearrangements in locus 42 GBM samples and found that was amplified 11.5% overexpressed all samples. These results prompted us further investigate mechanisms involved overexpression GBM. analyzed methylation status promoter because high CpG density promoters are associated with...
// Konrad Gabrusiewicz 1,* , Dan Liu Nahir Cortes-Santiago Mohammad B. Hossain 1 Charles A. Conrad Kenneth D. Aldape 2 Gregory N. Fuller Frank C. Marini 3 Marta M. Alonso 4 Miguel Angel Idoate 5 Mark R. Gilbert Juan Fueyo and Candelaria Gomez-Manzano 1,6 Department of Neuro-Oncology, The University Texas MD Anderson Cancer Center, Houston, Texas, USA Pathology, Institute Regenerative Medicine, Wake Forest University, Winston-Salem, North Carolina, Medical Oncology, Hospital Navarra,...
Received: December 14, 2010 , Accepted: 30, Published: // Malignant gliomas are the prototype of highly infiltrative tumors and this characteristic is main factor for inevitable tumor recurrence short survival after most aggressive therapies. The aberrant communication between glioma cells microenvironment represents one major factors regulating brain dispersal. Our group has previously reported that tyrosine kinase receptor Tie2/TEK expressed in stem associated with malignant progression...
OBJECTIVE: Glioblastoma multiforme is the most frequent primary brain tumor in adults. The major obstacle for successful treatment invasive growth pattern. Metabolically, glioblastomas are highly glycolytic, leading to increased levels of lactic acid production. carbonic anhydrase IX (CAIX) moderates extrusion hydrogen ions into extracellular space, which may enhance invasion by activating proteolytic enzymes. We therefore induced glycolysis glioblastoma cells and investigated pH, cathepsin...
Membrane-bound enzyme relocates to the cell nucleus modify chromatin, inducing cancer resistance radiotherapy.
Monocytes/macrophages are an influential component of the glioma microenvironment. However, understanding their diversity and plasticity constitute one most challenging areas research due to paucity models study these cells' inherent complexity. Herein, we analyzed role monocytes/macrophages in growth by using a transgenic model that allows for conditional ablation this cell population. We modeled intracranial GL261-bearing CSF-1R–GFP+ macrophage Fas-induced apoptosis (MAFIA) mice....
// Nahir Cortes-Santiago 1, 6 , Mohammad B. Hossain 1 Konrad Gabrusiewicz Xuejun Fan Joy Gumin 2 Frank C. Marini 3 Marta M. Alonso 4 Frederick Lang W.K. Yung Juan Fueyo Candelaria Gomez-Manzano 5, Department of Neuro-Oncology, The University Texas MD Anderson Cancer Center, Houston, TX, USA Neurosurgery, Comprehensive Wake Forest University, Winston-Salem, NC, Medical Oncology, Hospital Navarra, Pamplona, Spain 5 Genetics, Biology Program, Graduate School Biomedical Sciences at...
This is the first use of spatial transcriptomics in patients with congenital diaphragmatic hernia (CDH) that identifies contribution different lung cellular subpopulations CDH pathophysiology and highlights sex-specific differences.
Systematic study of allograft liver histology in children undergoing orthotopic transplantation (LT) for cystic fibrosis-related disease (CFLD).Retrospective clinicopathologic review explants and biopsies from 13 adolescents with CFLD.In this study, the median age at LT CFLD was 15.7 years. Notably, 10 (77%) CF had >5% steatosis 8 (61.5%) demonstrated variable fibrosis. The age, sex, type transplant (liver vs liver-lung), pancreatic insufficiency status, body mass index (BMI) percentile,...
The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies detection injury. A multidisciplinary panel reviewed state-of-the-art current histopathologic entities, serologic studies, molecular practices, as well applications digital with artificial intelligence, gene expression analysis, quantitative image analysis chest computerized tomography. Current states need...
Young males have a unique but rare predilection to develop mediastinal nonseminomatous germ cell tumors (NSGCTs) and concomitant acute megakaryoblastic leukemia (AMKL). Common cytogenetic molecular abnormalities such as isochromosome 12p somatic Tumor Protein P53(TP53) Phosphatase And Tensin Homolog (PTEN) mutations been reported in the presumed mutual neoplastic clones of origin. We report case 17-year-old male who presented with NSGCT high-grade sarcomatous transformation diagnosis AMKL...
Introduction and Aim Multiorgan autoimmunity interstitial lung disease (ILD) are reported in patients with STAT3 GOF syndrome. Results We present histopathology findings 3 such children, two of whom underwent wedge biopsies adequate diagnostic material. Wedge showed cellular expansion linear nodular aggregates CD8 positive T lymphocytes, plasma cells, histiocytes; consistent lymphocytic pneumonia pattern (LIP). CD4+ cells CD20+ B were but infrequent the interstitium. FOXP3 ranged from 0-5%....
Abstract Objective To investigate pulmonary histopathologic features in a cohort of pediatric patients with anti‐neutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) who underwent lung biopsy as part their evaluation. We report the safety and findings biopsies this population. Methods After IRB approval, we performed retrospective chart review all <18 years age presenting to our institution diagnosis AAV (pAAV) biopsy. reviewed features, serologies, timing biopsy,...