A5017444131- Gut microbiota and health
- Diet and metabolism studies
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Higher Education Teaching and Evaluation
- Stress Responses and Cortisol
- Probiotics and Fermented Foods
- Natural Antidiabetic Agents Studies
- Nutritional Studies and Diet
- Gastrointestinal motility and disorders
- Fatty Acid Research and Health
- Helicobacter pylori-related gastroenterology studies
- Sodium Intake and Health
Instituto de Investigación Biosanitaria de Granada
2016-2025
Universidad de Granada
2016-2025
The University of Texas Health Science Center at Houston
2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2023
Centro de Investigación Biomédica en Red
2008-2023
UCLouvain
2012-2023
Instituto de Salud Carlos III
2023
Complejo Hospitalario Universitario de Granada
2018
Universidad Complutense de Madrid
2008-2017
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2017
Association between gut dysbiosis and neurogenic diseases, such as hypertension, has been described. The aim of this study was to investigate whether changes in the microbiota alter gut-brain interactions inducing blood pressure (BP). Recipient normotensive Wistar-Kyoto (WKY) spontaneously hypertensive rats (SHR) were orally gavaged with donor fecal contents from SHR WKY. We divided animals into four groups: WKY transplanted (W-W), (S-S), (W-S) (S-W). Basal systolic BP (SBP) diastolic (DBP)...
The cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus gasseri CECT5714 (LC9) (1:1) in spontaneously hypertensive rats (SHR) were evaluated.Ten Wistar Kyoto (WKY) and 30 SHR randomly assigned to four groups (n = 10): a control WKY group, groups, an group treated with LC40, K8/LC9 for 5 weeks (at dose 3.3 × 10(10) colony-forming units/day drinking water). Long-term administration reduced systolic blood pressure. consumption...
Scope The objective of this study is to determine the cardiovascular effects probiotics Bifidobacterium breve CECT7263 (BFM) and Lactobacillus fermentum CECT5716 (LC40), short chain fatty acids butyrate, acetate in spontaneously hypertensive rats (SHR). Methods results Ten five‐week old Wistar Kyoto (WKY) fifty aged‐matched SHR are randomly distributed into six groups: control WKY, SHR, treated SHR‐LC40, SHR‐BMF, SHR‐butyrate, SHR‐acetate. Chronic treatments with LC40 or BFM increase...
Hydroxychloroquine has been shown to be efficacious in the treatment of autoimmune diseases, including systemic lupus erythematosus. Hydroxychloroquine-treated patients showed a lower incidence thromboembolic disease. Endothelial dysfunction, earliest indicator development cardiovascular disease, is present lupus. Whether hydroxychloroquine improves endothelial function not clear. The aim this study was analyze effects on hypertension, and renal injury female mouse model NZBWF1 (lupus)...
Obesity is associated with intestine dysbiosis and characterized by a low-grade inflammatory status, which affects vascular function. In the present study, we evaluated effects of probiotic immunomodulatory properties, Lactobacillus coryniformis CECT5711, in obese mice fed on an HFD (high-fat diet). The treatment was given for 12 weeks, it did not affect weight evolution, although reduced basal glycaemia insulin resistance. L. administration to HFD-induced induced marked changes microbiota...
High blood pressure (BP) is associated with gut microbiota dysbiosis. The aim of this study was to investigate whether changes in induced by exchanging the between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) alter gut-immune system interaction inducing vascular function BP.Twenty-week-old recipient WKY SHR were orally gavaged donor faecal contents from or SHR. In additional experiments, we used a design determine blockade B7-dependent costimulation CTLA4-Ig...
The aim is to analyze whether the probiotic Lactobacillus fermentum CECT5716 (LC40) can prevent endothelial dysfunction and hypertension induced by tacrolimus in mice.Tacrolimus increases systolic blood pressure (SBP) impairs endothelium-dependent relaxation acetylcholine these effects are partially prevented LC40. Endothelial related both increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) uncoupled nitric oxide synthase (eNOS)-driven superoxide production...
Hypertension is associated with gut dysbiosis. Here we have evaluated the effects of angiotensin receptor antagonist losartan on microbiota in spontaneously hypertensive rats (SHR) to assess their contribution its antihypertensive effects.Twenty-week-old Wistar Kyoto (WKY) and SHR were treated for 5 weeks (SHR-losartan). Faecal transplantation (FMT) was performed from donor SHR-losartan group recipient untreated-SHR. Blood pressure (BP) measured using tail-cuff plethysmography. Composition...
Red wine polyphenols (RWPs) have been reported to prevent hypertension and endothelial dysfunction. Several individual RWPs exert estrogenic effects. We analyzed the possible in vivo protective effects on blood pressure function of female spontaneously hypertensive rats (SHR) its relationship with ovarian function. (40 mg/kg by gavage) were orally administered for 5 weeks. Ovariectomized showed both increased isoprostaglandin F 2α excretion aortic superoxide production reduced relaxant...
Activation of nuclear hormone receptor peroxisome proliferator-activated β/δ (PPARβ) has been shown to improve insulin resistance and plasma high-density lipoprotein levels, but nothing is known about its effects in genetic hypertension. We studied whether the PPARβ agonist GW0742 might exert antihypertensive spontaneously hypertensive rats (SHRs). The were divided into 4 groups, Wistar Kyoto rat-control, rat-treated (GW0742, 5 mg · kg(-1) day(-1) by oral gavage), SHR-control, SHR-treated,...
Endothelial microparticles (EMPs) are endothelium-derived submicron vesicles that released in response to diverse stimuli and elevated cardiovascular disease, which is correlated with risk factors. This study investigates the effect of EMPs on endothelial cell function dysfunction a model free fatty acid (FFA) palmitate-induced oxidative stress. were generated from TNF-α-stimulated HUVECs quantified by using flow cytometry. treated without palmitate presence or absence EMPs. found carry...
Whether the probiotic Lactobacillus fermentum CECT5716 (LC40) ameliorates hypertension in rats with chronic nitric oxide (NO) synthase inhibition is tested.Rats are randomly divided into four different groups and treated for 4 weeks: a) vehicle (control), b) plus NG -nitro-l-arginine methyl ester (l-NAME; 50 mg 100 mL-1 drinking water), c) LC40 (109 colony-forming units d-1 by gavage), d) l-NAME. l-NAME induces gut dysbiosis, characterized mainly an increased Fimicutes/Bacteroidetes (F/B)...
The effects of chronic consumption oleuropein-enriched (15% w/w) olive leaf extract (OLE) on blood pressure, endothelial function, and vascular oxidative inflammatory status in spontaneously hypertensive rats (SHR) were evaluated.
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in cellular metabolism. One them to function as an electron carrier reaction catalyzed by sulfide:quinone oxidoreductase (SQR), which catalyzes first hydrogen sulfide oxidation pathway. Therefore, SQR may be affected CoQ deficiency. Using human skin fibroblasts and two mouse models with primary deficiency, we demonstrate that severe deficiency causes reduction levels activity,...
The aim of the present study was to examine whether immune-modulatory bacteria Lactobacillus fermentum CECT5716 (LC40) ameliorates disease activity and cardiovascular complications in a female mouse model lupus. Eighteen-week-old NZBWF1 [systemic lupus erythematosus (SLE)] NZW/LacJ (control) mice were treated with vehicle or LC40 (5 × 108 colony-forming units/d) for 15 wk. treatment reduced activity, blood pressure, cardiac renal hypertrophy, splenomegaly SLE mice. elevated T, B, regulatory...