A5103030469- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adipose Tissue and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Tumors and Oncological Cases
- Aldose Reductase and Taurine
- Poxvirus research and outbreaks
- Epigenetics and DNA Methylation
- Musculoskeletal pain and rehabilitation
- Bladder and Urothelial Cancer Treatments
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Myofascial pain diagnosis and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Phytochemicals and Medicinal Plants
- Cancer Immunotherapy and Biomarkers
- Occupational health in dentistry
- Transgenic Plants and Applications
- Cancer Cells and Metastasis
- Bacillus and Francisella bacterial research
- Biochemical effects in animals
- Cancer Genomics and Diagnostics
- Curcumin's Biomedical Applications
National Institute of Immunology
2023-2025
Dr. Ram Manohar Lohia Institute of Medical Sciences
2017-2023
Manav Rachna International Institute of Research and Studies
2023
Aging is associated with changes in circulating levels of various molecules, some which remain undefined. We find that concentrations taurine decline aging mice, monkeys, and humans. A reversal this through supplementation increased the health span (the period healthy living) life mice monkeys. Mechanistically, reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, attenuated inflammaging. In humans, lower correlated...
Aims Programmed death‐ligand 1 ( PD ‐L1), a potential target for immune checkpoint inhibitors in various solid neoplasms, has been studied very few cases of Gall Bladder Carcinoma GBC ). The current study aimed to evaluate ‐L1 expression at primary and metastatic sites , its associations with standard prognostic clinicopathological parameters, as well overall survival. Methods results One hundred seventy‐four were evaluated by the use SP 263 clone tissue microarrays. Clinicopathological...
Purpose: Liquid biopsy has entered the arena of cancer diagnostics in past decade and detection circulating tumor cells (CTC) is one diagnostic component. CTCs gallbladder (GBC) have hitherto not been comprehensively analysed. Methods Results: The current study focused on role 27 cases treatment-naive GBC 6 normal controls as well cholecystitis. An EasySep kit featuring negative immunomagnetic bead separation flow cytometric EpCAM positive CD45 revealed 25 cases. At a cut-off point ≥1, CTC...
Liquid biopsy has moved from bench to bedside as a non-invasive biomarker for early diagnosis and monitoring treatment response.This study investigated the role of circulating free DNA (cfDNA) diagnostic marker in locally advanced head neck squamous cell carcinoma (HNSCC) response chemoradiation therapy.Serum was collected naïve, histopathologically diagnosed tumors 24 HNSCC cases 16 normal controls. CfDNA levels were quantified using β globin gene amplification.The cfDNA level significantly...
Background: Identification of plasma cells into abnormal (APC) and normal (NPC) compartments is utmost importance in flow cytometric (FC) analysis multiple myeloma (MM) related cell dyscrasias for diagnosis, prognosis, follow-up. No single phenotypic marker sufficient to distinguish NPC from APC. Materials Methods: 43 newly diagnosed cases MM 13 controls were included the study. Bone marrow (BM) samples 2 nd pass processed on same day with antibodies against CD38, CD138, CD19, CD81, CD45,...
Objective:The purpose of the study was to examine psychometric properties Northwick Park Pain Questionnaire (NPQ) by translating it from English Hindi and evaluating its content validity internal consistency aiming feasibility in assessing neck pain.Materials Methods: This cross-sectional included 60 patients who had been experiencing noninflammatory pain for at least 4 months.The properties, test-retest reliability back translated version assessed compared with original version.A panel six...